Canagliflozin heMihydrate

ChemicalBook > CAS DataBase List > Canagliflozin heMihydrate

Canagliflozin heMihydrate

Product Name: Canagliflozin heMihydrate
CAS No.: 928672-86-0
Chemical Name: Canagliflozin heMihydrate
Synonyms: Canagliflozin hydrate;Cagliflozin heMihydrate;(2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Hemihydrate;Cageline;NSC 36678;NSC 406879;Kagliflozin;TA7284 hemihydrate;TA-7284 hemihydrate;Invokana hemihydrate
CBNumber: CB32677171
Molecular Formula: 2(C24H25FO5S).H2O
Formula Weight: 462.53
MOL File: 928672-86-0.mol

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Canagliflozin heMihydrate Property

Melting point:: 94-96°C
storage temp.: Hygroscopic, Refrigerator, under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
InChIKey: RCCZPUWDQVUJAB-HNJBBDRUNA-N
SMILES: O[C@@H]1[C@H]([C@H](O)[C@@H](CO)O[C@H]1C1C=CC(C)=C(CC2=CC=C(C3C=CC(F)=CC=3)S2)C=1)O.O |&1:1,2,3,5,9,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C175258
Product name: CanagliflozinHemihydrate
Packaging: 10mg
Price: $65
Updated: 2021/12/16

TRC

Product number: C175258
Product name: CanagliflozinHemihydrate
Packaging: 50mg
Price: $140
Updated: 2021/12/16

AK Scientific

Product number: 2301AH
Product name: Canagliflozinhemihydrate
Packaging: 10mg
Price: $143
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC103621
Product name: Canagliflozin hemihydrate
Packaging: 100mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-3205
Product name: Canagliflozinhemihydrate
Purity: 99.95%
Packaging: 10mg
Price: $70
Updated: 2021/12/16

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Canagliflozin heMihydrate Chemical Properties,Usage,Production

Description

Canagliflozin, an orally active and selective sodium–glucose cotransporter 2 (SGLT2) inhibitor, was co-developed by Mitsubishi Tanabe Pharma and Johnson & Johnson (J&J) for the treatment of type 2 diabetes mellitus (T2DM) and obesity. The drug was approved in March by the U.S. FDA and launched in April 2013 in the U.S. SGLT2 is involved in the glucose re-absorption pathway in the kidney, and its inhibition increases urinary glucose excretion, and reduces plasma glucose and HbA1c levels. In addition, canagliflozin is safe in combination with other commonly used antidiabetic agents and has a significant effect on body weight reduction. A recently published process patent from ScinoPharm Taiwan describes the synthesis of canagliflozin.

Uses

Canagliflozin Hemihydrate is a derivative of Canagliflozin (C175190), which is a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.

Definition

ChEBI: Canagliflozin hydrate is a hydrate that is the hemihydrate form of canagliflozin. Used for treatment of type II diabetes via inhibition of sodium-glucose transport protein subtype 2. It has a role as a hypoglycemic agent and a sodium-glucose transport protein subtype 2 inhibitor. It contains a canagliflozin.

Synthesis

Synthesis of the aglycone region of canagliflozin was described in a separate patent by first condensing commercially available 5- bromo-2-methylbenzoyl chloride (14) and 2-(4-fluorophenyl)- thiophene (15) under Friedel¨CCrafts acylation conditions to give ketone 16 in 69% yield as a crystalline solid. Ketone 16 was then reduced with triethylsilyl hydride in the presence of BF3Et2O at low temperature to give aglycone bromide 17 in 70% yield. The precursor for the glycoside moiety, commercially available glycoside triol 18, was selectively treated with t-butyldiphenylsilyl chloride (TBDPSCl) in THF in the presence of imidazole to give the bis-silyl ether 19 in 81% yield. Next, a unique, stereospecific b-C-arylglucosidation was developed to secure the union of the aglyone- and glycoside-containing portions of canagliflozin. Bromide 17 was subjected to magnesium powder under standard Grignard conditions prior to treatment with AlCl3 in THF in situ. This resulting mixture was then exposed to a solution of compound 19 in PhOMe which had been pre-treated with n-BuLi, and the entire mixture was then warmed to 150 ?? for 5 h to ultimately give the b-anomer 20 in 56% yield. Finally, removal of the silyl groups within 20 with tetrabutyl ammonium fluoride (TBAF) in THF delivered canagliflozin hydrate (III) in 73% yield.

Canagliflozin heMihydrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Canagliflozin heMihydrate Suppliers

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View Lastest Price from Canagliflozin heMihydrate manufacturers

Nanjing Fred Technology Co., Ltd

Product: Canagliflozin hemihydrate 928672-86-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%，single impurity＜0.1
Supply Ability: 1 ton
Release date: 2024-01-04

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Canagliflozin Hemihydrate 928672-86-0
Price: US $0.00/G
Min. Order: 1G
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-09-04

Hebei Weibang Biotechnology Co., Ltd

Product: Canagliflozin heMihydrate 928672-86-0
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2021-10-09

928672-86-0, Canagliflozin heMihydrateRelated Search:

1-Chloro-2-(4-ethoxybenzyl)-4-iodobenzene 2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE 5-Bromo-2-methylbenzoic acid D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-, tetraacetate, (1S)- (9CI) 2-(5-BroMo-2-Methylbenzyl)-5-(4-fluorophenyl)thiophene (5-broMo-2-Methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)Methanone 2-(4-Fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene 5-Bromo-2-methylbenzoyl chloride 5-Iodo-2-methylbenzoic acid 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone LIPOPHILIC SEPHADEX 2-(4-Fluorophenyl)-thiophene Canagliflozin Canagliflozin Enantiomer Impurity Canglietate five-membered ring impurity Canagliflozin α Isomer Canagliflozin impurity BCP19353

Cagliflozin heMihydrate

Canagliflozin hydrate (2:1)

Canagliflozin heMihydrate

D-Glucitol, 1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]Methyl]-4-Methylphenyl]-, hydrate (2:1)

Canagliflozin heMihydrates

(2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol Hemihydrate

(1S)-1,5-Anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol hydrate (2:1)

Cageline

Invokana hemihydrate

JNJ 28431754 hemihydrate

JNJ28431754 hemihydrate

JNJ-28431754 hemihydrate

JNJ28431754 HEMIHYDRATE; JNJ-28431754 HEMIHYDRATE; JNJ 28431754 HEMIHYDRATE; TA-7284 HEMIHYDRATE; TA7284 HEMIHYDRATE; INVOKANA HEMIHYDRATE

TA7284 hemihydrate

TA-7284 hemihydrate

Canagliflozin hydrate

bis((2S,3R,4R,5S,6R)-2-(3-{[5-(4-fluorophenyl)thio phen-2-yl]methyl}-4-methylphenyl)-6-(hydroxymet hyl)oxane-3,4,5-triol) hydrate

Canagliflozin (API)

Canagli ozin Hemi hydrate

(1S)-1,5-anhydro-1-C-[3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl]-D-glucitol Hemihydrate

Canagliflozin hemihydrate (JNJ 28431754)

TIANFU-CHEM 928672-86-0 Canagliflozin heMihydrate

NSC 36678

NSC 406879

Kaglie net semihydrate

(2S,3R,4R,5S,6R)-2-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-4-methylphenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol hydrate

Kagliflozin

CANIGLAFOZIN HEMIHYDRATE

928672-86-0

2C24H25FO5SH2O

C24H25FO5SH2O

C24H25FO5S12H2O

Canagliflozin

API

928672-86-0