ChemicalBook > CAS DataBase List > (R)-2-(methoxycarbonylamino)-2-phenylacetic acid

(R)-2-(methoxycarbonylamino)-2-phenylacetic acid

Product Name
(R)-2-(methoxycarbonylamino)-2-phenylacetic acid
CAS No.
50890-96-5
Chemical Name
(R)-2-(methoxycarbonylamino)-2-phenylacetic acid
Synonyms
Moc-D-Phg;Moc-D-Phg-OH;Velpatasvir Impurity 28;MOC-D-phenylglycine acid;(R)-2-(methoxycarbonylamino)-2-phenyl;(R)-2-(methoxycarbonylamino)-2-phenylaceticaci;(R)-2-(methoxycarbonylamino)-2-phenylacetic acid;(αR)-α-[(Methoxycarbonyl)amino]benzeneacetic acid;(R)-2-(Methoxycarbonylamino)-2-phenylethanoic acid;(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetic acid
CBNumber
CB32681677
Molecular Formula
C10H11NO4
Formula Weight
209.2
MOL File
50890-96-5.mol
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(R)-2-(methoxycarbonylamino)-2-phenylacetic acid Property

Melting point:
120 °C
Boiling point:
391.3±35.0 °C(Predicted)
Density 
1.283±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
pka
3.96±0.10(Predicted)
color 
White to Almost white
optical activity
Consistent with structure
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
M3293
Product name
N-Methoxycarbonyl-D-phenylglycine
Packaging
25G
Price
$25
Updated
2025/07/31
TCI Chemical
Product number
M3293
Product name
N-Methoxycarbonyl-D-phenylglycine
Packaging
100G
Price
$68
Updated
2025/07/31
TRC
Product number
M342968
Product name
(R)-2-((Methoxycarbonyl)amino)-2-phenylaceticAcid
Packaging
50mg
Price
$175
Updated
2021/12/16
ChemScene
Product number
CS-0036426
Product name
(R)-2-((Methoxycarbonyl)amino)-2-phenylaceticacid
Purity
>97.0%
Packaging
100g
Price
$56
Updated
2021/12/16
ChemScene
Product number
CS-0036426
Product name
(R)-2-((Methoxycarbonyl)amino)-2-phenylaceticacid
Purity
>97.0%
Packaging
500g
Price
$167
Updated
2021/12/16
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(R)-2-(methoxycarbonylamino)-2-phenylacetic acid Chemical Properties,Usage,Production

Uses

(R)-2-((Methoxycarbonyl)amino)-2-phenylacetic acid is a Glycine.html" class="link-product" target="_blank">Glycine (HY-Y0966) derivative[1].

Synthesis

875-74-1

79-22-1

50890-96-5

D-Phenylglycine (10.0 g, 66.1 mmol) and sodium hydroxide (21.2 g, 265 mmol) were dissolved in water (60 mL) at 0°C and stirred until completely dissolved. Subsequently, methyl chloroformate (10.2 mL, 133 mmol) was added slowly and dropwise over 20 minutes. The reaction mixture was continued to be stirred at 0°C for 1 hour. Upon completion of the reaction, it was acidified with concentrated hydrochloric acid (25 mL, 300 mmol) to pH < 2. The acidic aqueous phase was extracted with ethyl acetate (3 x 100 mL), the organic phases were combined and dried over anhydrous magnesium sulfate. After filtration to remove the desiccant, the organic phase was concentrated under reduced pressure to afford N-methoxycarbonyl-D-phenylglycine (Int-2a, 12.6 g, 91% yield), which could be used for subsequent reactions without further purification.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

(R)-2-(methoxycarbonylamino)-2-phenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R)-2-(methoxycarbonylamino)-2-phenylacetic acid manufacturers

Henan Fengda Chemical Co., Ltd
Product
(R)-2-(methoxycarbonylamino)-2-phenylacetic acid 50890-96-5
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-22
Hangzhou ICH Biofarm Co., Ltd
Product
(R)-2-(methoxycarbonylamino)-2-phenylacetic acid 50890-96-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
97%
Supply Ability
100kg
Release date
2023-06-30
Guangzhou Sunton Biotechnology Co., Ltd.
Product
Moc-D-phenylglycine 50890-96-5
Price
US $48.00-40.00/KG
Min. Order
1化验
Purity
99%
Supply Ability
2tons
Release date
2021-06-04

50890-96-5, (R)-2-(methoxycarbonylamino)-2-phenylacetic acidRelated Search:

PHENACETURIC ACID Moc-Ile-OH Moc-Val-Val-OH 1,2-Pyrrolidinedicarboxylicacid,1-methylester,(2S)-(9CI) (2S,4S)-1-(tert-butoxycarbonyl)-4-(MethoxyMethyl)pyrrolidine-2-carboxylic acid N-BOC-CIS-4-CYANO-L-PROLINE METHYL ESTER Velpatasvir intermediate Velpatasvir Velpatasvir intermediate Velpatasvir intermediate Velpatasvir Co Povidone Velpatasvir intermediate (2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidine-2-carboxylic acid BOC-L-PYROGLUTAMIC ACID BENZYL ESTER Velpatasvir-A12 MOC-D-Valine Methoxycarbonyl-L-tert-leucine Benzeneacetic acid, a-[(Methoxycarbonyl)aMino]-, (S)-

  • (R)-2-(methoxycarbonylamino)-2-phenylacetic acid
  • (R)-2-(methoxycarbonylamino)-2-phenyl
  • Moc-D-Phg-OH
  • (R)-2-(Methoxycarbonylamino)-2-phenylethanoic acid
  • (alphaR)-alpha-[(Methoxycarbonyl)amino]benzeneacetic acid
  • (2R)-2-[(methoxycarbonyl)amino]-2-phenylacetic acid
  • Moc-D-Phg
  • Benzeneacetic acid, a-[(methoxycarbonyl)amino]-, (aR)-
  • Benzeneacetic acid, α-[(methoxycarbonyl)amino]-, (αR)-
  • (R)-2-(methoxycarbonylamino)-2-phenylaceticaci
  • (αR)-α-[(Methoxycarbonyl)amino]benzeneacetic acid
  • Velpatasvir Impurity 28
  • MOC-D-phenylglycine acid
  • 50890-96-5
  • intermediates