Quinoxaline, 2-chloro-7-fluoro-
- Product Name
- Quinoxaline, 2-chloro-7-fluoro-
- CAS No.
- 1233932-59-6
- Chemical Name
- Quinoxaline, 2-chloro-7-fluoro-
- Synonyms
- 2-chloro-7-fluoroquinoxaline;Quinoxaline, 2-chloro-7-fluoro-
- CBNumber
- CB32681990
- Molecular Formula
- C8H4ClFN2
- Formula Weight
- 182.58
- MOL File
- 1233932-59-6.mol
Quinoxaline, 2-chloro-7-fluoro- Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C989643
- Product name
- 2-Chloro-7-fluoroquinoxaline
- Packaging
- 100mg
- Price
- $330
- Updated
- 2021/12/16
- Product number
- 4469AA
- Product name
- 2-Chloro-7-fluoroquinoxaline
- Packaging
- 100mg
- Price
- $217
- Updated
- 2021/12/16
- Product number
- HCH0363637
- Product name
- 2-CHLORO-7-FLUOROQUINOXALINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.13
- Updated
- 2021/12/16
- Product number
- 4469AA
- Product name
- 2-Chloro-7-fluoroquinoxaline
- Packaging
- 5g
- Price
- $1637
- Updated
- 2021/12/16
- Product number
- 4469AA
- Product name
- 2-Chloro-7-fluoroquinoxaline
- Packaging
- 10g
- Price
- $2571
- Updated
- 2021/12/16
Quinoxaline, 2-chloro-7-fluoro- Chemical Properties,Usage,Production
Synthesis
145323-53-1
1233932-59-6
Synthesis of 2-chloro-7-fluoroquinoxaline: 7-fluoroquinolin-2(1H)-one (2.60 g, 15.84 mmol, 1.0 eq.) was mixed with phosphorochloridic acid chloride (50 mL, 536.4 mmol, 34.0 eq.) and the reaction was carried out at reflux for 1 hour. Upon completion of the reaction, the mixture was concentrated, diluted with water (60 mL) and the pH was adjusted with saturated aqueous sodium bicarbonate to 7. Subsequently, the reaction mixture was extracted with ethyl acetate (3 x 100 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was purified by column chromatography (silica gel, eluent: ethyl acetate/petroleum ether, 1:20, v/v) to afford 2-chloro-7-fluoroquinoxaline as a white solid (2.50 g, 84% yield).1H-NMR (400 MHz, DMSO-d6) δ ppm: 8.98 (s, 1H), 8.22 (dd, J = 2.0, 8.8 Hz, 1H ), 7.81-7.89 (m, 2H). ms m/z (+EI): 183.0 [M + H]+.
References
[1] Patent: WO2010/84152, 2010, A1. Location in patent: Page/Page column 55
Quinoxaline, 2-chloro-7-fluoro- Preparation Products And Raw materials
Raw materials
Preparation Products
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