Pranlukast

Asthma drugs

Product Name: Pranlukast
CAS No.: 103177-37-3
Chemical Name: Pranlukast
Synonyms: Onon;rs411;Ultair;ono1078;Prenast;Prandtl;Pranlukas;ONO-RS-411;emihydrate;PRANLUKAST
CBNumber: CB3271355
Molecular Formula: C27H23N5O4
Formula Weight: 481.5
MOL File: 103177-37-3.mol

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Pranlukast Property

Melting point:: 236-238°C
Density: 1.374±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO (up to 25 mg/ml)
pka: 4.96±0.10(Predicted)
form: solid
color: White
Merck: 14,7710
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey: NBQKINXMPLXUET-UHFFFAOYSA-N
SMILES: C(NC1=C2OC(C3=NNN=N3)=CC(=O)C2=CC=C1)(=O)C1=CC=C(OCCCCC2=CC=CC=C2)C=C1
CAS DataBase Reference: 103177-37-3(CAS DataBase Reference)

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Safety

Hazard Codes: F,C
Risk Statements: 11-34
Safety Statements: 16-26-36/37/39-45
RTECS: CV5647500
HS Code: 2934.99.4400
Toxicity: LD50 in male mice (mg/kg): >1000 i.v. (Toda)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: P2115
Product name: Pranlukast
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: P2115
Product name: Pranlukast
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $108
Updated: 2025/07/31

Cayman Chemical

Product number: 10008319
Product name: Pranlukast
Purity: ≥98%
Packaging: 10mg
Price: $19
Updated: 2024/03/01

Cayman Chemical

Product number: 10008319
Product name: Pranlukast
Purity: ≥98%
Packaging: 100mg
Price: $138
Updated: 2024/03/01

Cayman Chemical

Product number: 10008319
Product name: Pranlukast
Purity: ≥98%
Packaging: 500mg
Price: $595
Updated: 2024/03/01

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Pranlukast Chemical Properties,Usage,Production

Asthma drugs

Pranlukast is a common respiratory drug, it belongs to asthma drugs , it is the cysteinyl leukotrienes (LTs) receptor antagonist and it can bind to LTC4, LTD4, LTE4 receptors selectively to antagonize their effect . Roles and application are similar to zafirlukast. It is clinically used for the prevention of bronchial asthma. Oral 225mg once, 2 times one day, morning and evening after meal. After taking ,there may be gastrointestinal reactions,or there may be nausea, vomiting, abdominal pain, diarrhea or constipation, sometimes , fever, rash, pruritus and liver function abnormalities such as serum aminotransferase or bilirubin increase are visible . Pregnant women should use with caution , the elderly should take appropriate reductions. This product can not alleviate the onset of asthma.
At present, three leukotriene receptor antagonists are used for the following purposes:
1, zafirlukast :it is effective for mild to moderate asthma ,it can cause improvement in dose-dependent lung function, and reduce the amount of β agonists. Absorption of the product is affected by food, it should not be taken together with food. Oral each 20mg, 2 times/d.
2, montelukast: it is valid for intermittent or persistent asthma in adults and children. This product is approved by the FDA for the treatment of children aged 6 to 12. Absorption of the product is not affected by food, it can be taken with food . Oral each 10mg, once/d.
3, pranlukast :it is used for mild to moderate asthma, pranlukast can increase patients maximum expiratory flow,and improve asthma symptoms, it can be used as a daily treatment of chronic asthma. Each oral 450mg, 2 times/d.
The above information is edited by the chemicalbook of Tian Ye.

Description

Pranlukast, a novel chromone derivative, was introduced in Japan for the treatment of bronchial asthma and allergic diseases. Pranlukast is a highly potent, selective and competitive antagonist of peptidoleukotrienes with high affinity for the LTD₄ receptor. In patients with bronchial asthma, pranlukast was reported to induce significant improvement in both immediate and late asthmatic response induced by antigen. Pranlukast is also being evaluated clinically for the treatment of perennial allergic rhinitis, pediatric asthma, and cutaneous pruritus in dialysis patients. The therapeutic potential of pranlukast in managing irritable bowel syndrome has been suggested.

Chemical Properties

Off-white solid

Originator

Ono (Japan)

Uses

A potent, selective and orally active CysLT receptor antagonist. Leukotriene antagonist. Used as an antiasthmatic

Uses

antiasthmatic;leukotriene receptor-1 antagonist

Uses

Labeled Pranlukast, intended for use as an internal standard for the quantification of Pranlukast by GC- or LC-mass spectrometry.

Definition

ChEBI: N-[4-oxo-2-(2H-tetrazol-5-yl)-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide is a member of chromones.

brand name

Onon

Biological Activity

Selective cysteinyl leukotriene receptor 1 (CysLT 1 ) antagonist (IC 50 values are ~ 4-7 and 3620 nM for CysLT 1 and CysLT 2 respectively). Inhibits contraction of airway smooth muscle, microvascular leakage into airways and eosinophil infiltration. Can decrease symptoms of bronchial asthma.

References

[1] HISAO NAKAI. New potent antagonists of leukotrienes C4 and D4. 1. Synthesis and structure-activity relationships[J]. Journal of Medicinal Chemistry, 1988, 31 1: 84-91. DOI:10.1021/jm00396a013
[2] YUKIHIKO TANIGUCHI MD. The effect of an oral leukotriene antagonist, ONO-1078, on allergen-induced immediate bronchoconstriction in asthmatic subjects[J]. Journal of Allergy and Clinical Immunology, 1993, 92 4: Pages 507-512. DOI:10.1016/0091-6749(93)90074-p
[3] PAOLO CIANA. The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor.[J]. EMBO Journal, 2006, 25 19: 4615-4627. DOI:10.1038/sj.emboj.7601341
[4] STEPHANIE HENNEN. Decoding Signaling and Function of the Orphan G Protein–Coupled Receptor GPR17 with a Small-Molecule Agonist[J]. Science Signaling, 2013, 6 298. DOI:10.1126/scisignal.2004350

Pranlukast Preparation Products And Raw materials

Raw materials

Preparation Products

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Pranlukast Suppliers

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View Lastest Price from Pranlukast manufacturers

Shaanxi Xianhe Biotech Co., Ltd

Product: Pranlukast 103177-37-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000kg
Release date: 2025-05-07

Hebei Chuanghai Biotechnology Co., Ltd

Product: Pranlukast 103177-37-3
Price: US $10.00/KG
Min. Order: 100KG
Purity: 99%
Supply Ability: 100 mt
Release date: 2024-12-03

Hebei Ganmiao New material Technology Co., LTD

Product: Pranlukast 103177-37-3
Price: US $10.00-7.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 20ton
Release date: 2024-06-06

103177-37-3, PranlukastRelated Search:

Kasumi-1 NRK-49F NEC8 Haloperidol Flurbiprofen Zafirlukast Montelukast sodium 8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran OCI-LY10 (diffuse large B cell lymphoma cells) MMVECS mouse cardiac microvascular endothelial cells JG mouse paraglomerular cells Butoxybenzene Pranlukast 3-Amino-2-hydroxyacetophenone 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE 4-ETHOXY-N-PHENYLBENZAMIDE 4-ethoxy-N-(2-methoxyphenyl)benzamide 4-METHOXY-N-(2-METHOXYPHENYL)BENZAMIDE

PRANLUKAST

4-oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4h-1-benzopyranh

benzamide,n-(4-oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl)-4-(4-phenylbutox

emihydrate

ONO-RS-411

ONO-RS-411-01

N-[4-keto-2-(2H-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide

N-[4-oxo-2-(2H-1,2,3,4-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide

N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-7-yl]-4-(4-phenylbutoxy)benzamide

n-(4-oxo-2-(1h-tetrazol-5-yl)-4h-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzam

BenzaMide,N-[4-oxo-2-(2H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-

N-[4-oxo-2-(2H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-benzamide

4-Oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4H-1-benzopyran4-Oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4H-1-benzopyran

Pranlukast-d4

Onon

Pranlukast (ONO 1078)

ono1078

rs411

N-{4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide, ONO-1078, ONO-RS-411, Onon,

4-Oxo-8-(4-(4-phenylbutoxy)benzoylamino)-2-(tetrazol-5-yl)-4H-1-benzopyran

N-(4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl)-4-(4-phenylbutoxy)benzamide

N-[4-oxo-2-(2H-tetrazol-5-yl)-1-benzopyran-8-yl]-4-(4-phenylbutoxy)benzamide

Pranlukast &gt

Pranlukast RS

Pranlukas

EP/GMP/FDA Pranlukast

Pranlukast USP/EP/BP

Pranlukast (1.0mg/ml in DMSO)

Pranlukast (10mM in DMSO)

Pranlukast D4Q: What is Pranlukast D4 Q: What is the CAS Number of Pranlukast D4 Q: What is the storage condition of Pranlukast D4 Q: What are the applications of Pranlukast D4

Prenast

Ultair

Prandtl

103177-37-3

C27H23N5O4

API

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Antiasthmatic