EveroliMus-d4

Product Name: EveroliMus-d4
CAS No.: 1338452-54-2
Chemical Name: EveroliMus-d4
Synonyms: Everolimus-d4;EveroliMus-d4 (~90%);Everolimus-d4 (Everolimus Impurity);EVEROLIMUS (2-HYDROXYETHYL-D4, 98%);Everolimus Impurity 24(Everolimus-d4);Everolimus D4Q: What is Everolimus D4 Q: What is the CAS Number of Everolimus D4 Q: What is the storage condition of Everolimus D4 Q: What are the applications of Everolimus D4
CBNumber: CB32714520
Molecular Formula: C53H79D4NO14
Formula Weight: 962.249067112
MOL File: 1338452-54-2.mol

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EveroliMus-d4 Property

storage temp.: Store at 4°C
solubility: Chloroform: Soluble,Methanol: Soluble
form: A solid
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H372Causes damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E-070
Product name: Everolimus-D4 solution
Purity: 100?μg/mLinacetonitrile,ampuleof1?mL,certifiedreferencematerial,Cerilli
Packaging: 1mL
Price: $586
Updated: 2024/03/01

Cayman Chemical

Product number: 22559
Product name: Everolimus-d4
Purity: ≥99% deuterated forms (d1-d4); ≤1% d0
Packaging: 500μg
Price: $145
Updated: 2024/03/01

Cayman Chemical

Product number: 22559
Product name: Everolimus-d4
Purity: ≥99% deuterated forms (d1-d4); ≤1% d0
Packaging: 1mg
Price: $262
Updated: 2024/03/01

TRC

Product number: E945402
Product name: Everolimus-d4(~90%)
Packaging: 10mg
Price: $1695
Updated: 2021/12/16

IsoSciences

Product number: 14001
Product name: Everolimus-[d4]
Purity: ≥98%
Packaging: 1mg
Price: $190
Updated: 2021/12/16

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EveroliMus-d4 Chemical Properties,Usage,Production

Description

Everolimus-d₄ is intended for use as an internal standard for the quantification of everolimus by GC- or LC-MS. Everolimus is a hydroxyethyl ether form of rapamycin that inhibits mTOR signaling through both mTORC1 and mTORC2 when added to cells at 20 nM. It is orally available and shows improved pharmacokinetics and pharmacodynamics over rapamycin. Through its inhibition of mTOR, everolimus inhibits cell proliferation, metabolism, and angiogenesis in certain types of cancer. It also acts as an immunosuppressive agent in the context of organ transplantation.

Uses

Macrolide immunosuppressant; derivative of Rapamycin. Inhibits cytokine-mediated lymphocyte proliferation.

General Description

A stable-labeled internal standard for the immunosuppressant Everolimus, marketed as Zortress^? and Certican for use in organ transplantation and Afinitor^? for treatment of kidney and pancreatic cancers. Clinical laboratories quantitate everolimus levels in patient whole blood samples using LC-MS/MS. While many everolimus LC-MS/MS methods use 32-desmethoxyrapamycin or ascomycin as an internal standard, higher levels of variability / lower levels of reproducibility may occur in the analysis along with the potential for interferences. Use of a stable-labeled analog of everolimus is the best choice to minimize variability or mitigate any potential interference in LC-MS/MS analysis.

EveroliMus-d4 Preparation Products And Raw materials

Raw materials

Preparation Products

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EveroliMus-d4 Suppliers

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1338452-54-2, EveroliMus-d4Related Search:

Everolimus O-Ethyl Impurity EveroliMus iMpurity Everolimus Related Compound 3 Everolimus Everolimus Ring-Opening Impurity 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone Everolimus Impurity 1 USDOYNAPNXMXOE-SPSCNLKESA-N 23,27-Epoxy(7E,15E,17E,19E)-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-[(1R)-2-[(1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl]-1-methylethyl]-10,21-dimethoxy-6,8,12,14,20,26-hexam... Rapamycin, 32-O-demethyl- Seco Rapamycin Everolimus Hydrolized Impurity 28-epirapamycin BIS(T-BUTYLDIMETHYLSILOXY)ETHANE Methanesulfonic acid, trifluoro-, 2-hydroxyethyl ester Ethyleneglycol bistriflate Everolimus Related Compound 2 2-(tert-butyldiMethylsilyl )oxyl alcohol trifluorin Methanesulfonate

EveroliMus-d4 (~90%)

Everolimus Impurity 24(Everolimus-d4)

EVEROLIMUS (2-HYDROXYETHYL-D4, 98%)

Everolimus-d4

Everolimus D4Q: What is Everolimus D4 Q: What is the CAS Number of Everolimus D4 Q: What is the storage condition of Everolimus D4 Q: What are the applications of Everolimus D4

Everolimus-d4 (Everolimus Impurity)

1338452-54-2