ChemicalBook > CAS DataBase List > Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
- Product Name
- Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
- CAS No.
- 205448-65-3
- Chemical Name
- Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
- Synonyms
- methyl 4-hydroxy-7-methoxyquinoline-6-carboxylate;lenvaint-C;FMX14227-A2;Lenvatinib Impurity 62;Lenvatinib Intermediate3;Methyl 7-Methoxy-4-oxo-1;4-dihydroquinoline-6-carboxylate;Methyl 7-methoxy-4-oxo-1,4-dihydroquinoline-6-;1,4-dihydro-7-methoxy-4-oxo-6-quinolinecarboxylic;7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
- CBNumber
- CB32714984
- Molecular Formula
- C12H11NO4
- Formula Weight
- 233.22
- MOL File
- 205448-65-3.mol
More
Less
Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate Property
- Boiling point:
- 421.0±45.0 °C(Predicted)
- Density
- 1.267±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, protect from light
- pka
- -0.53±0.50(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C12H11NO4/c1-16-11-6-9-7(10(14)3-4-13-9)5-8(11)12(15)17-2/h3-6H,1-2H3,(H,13,14)
- InChIKey
- TYKSVPGCVLNVIO-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(C(OC)=O)C(OC)=C2)C(=O)C=C1
More
Less
Safety
- HS Code
- 2933499090
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
Apolloscientific
- Product number
- OR470912
- Product name
- Methyl7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
- Packaging
- 1g
- Price
- $144
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4H58-1-501
- Product name
- Methyl 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
- Packaging
- 1g
- Price
- $159
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR470912
- Product name
- Methyl7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
- Packaging
- 5g
- Price
- $507
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4H58-1-501
- Product name
- Methyl 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
- Packaging
- 5G
- Price
- $559
- Updated
- 2021/12/16
AK Scientific
- Product number
- 0005AP
- Product name
- Methyl7-methoxy-4-oxo-1,4-dihydro-6-quinolinecarboxylate
- Packaging
- 10g
- Price
- $697
- Updated
- 2021/12/16
More
Less
Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate Chemical Properties,Usage,Production
Synthesis
205448-64-2
205448-65-3
General procedure for the synthesis of methyl 7-methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate from methyl 4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)methylamino)-2-methoxybenzoate: 5-((3-methoxy-4-methoxycarbonyloxyanilino)methylene-2,2-dimethyl-1,3-dioxane-4, 6-dione (10 g, 29.8 mmol) was suspended in DOWTHERM A (125 ml) and heated to 180-190 °C within 30 min. The raw material dissolved at 100°C and carbon dioxide began to be released at about 180°C. Heating was continued for 30 minutes and then stopped. As the reaction mixture cooled, the product gradually precipitated. When the temperature drops to 40°C, ether is added and the mixture is stirred for 30 minutes. The solid product was collected by filtration, washed with ether and dried under vacuum to afford 7-methoxy-6-methoxycarbonyl-1,4-dihydroquinolin-4-one (5.56 g, 80% yield). The structure of the product was confirmed by 1H NMR spectroscopy: (DMSO-d6) δ 3.80 (s, 3H); 3.85 (s, 3H); 5.95 (d, 1H); 7.00 (s, 1H); 7.85 (d, 1H); 8.40 (s, 1H); 11.6 (br s, 1H); MS-ESI: 234 [MH]+.
References
[1] Patent: US6809097, 2004, B1. Location in patent: Page column 67
[2] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1649 - 1667
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1668 - 1680
[4] Patent: EP1724268, 2006, A1. Location in patent: Page/Page column 48
[5] Patent: EP3293177, 2018, A1. Location in patent: Paragraph 0199; 0201
Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate Suppliers
- Tel
- 0531-88924771 15614660963
- elsa.hang@strongerscience.com
- Country
- China
- ProdList
- 10623
- Advantage
- 58
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 021-50460086-9 15921403865
- Fax
- +86-21-50462321
- han_yajun@dctc.daicel.com
- Country
- China
- ProdList
- 7471
- Advantage
- 65
- Tel
- 0731-85526065 13308475853
- ivy@hnhbsj.com
- Country
- China
- ProdList
- 7247
- Advantage
- 62
- Tel
- 0755-4000505016 13380397412
- Fax
- 0755 28094224
- 3001272453@qq.com
- Country
- China
- ProdList
- 5158
- Advantage
- 50
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 21-33585366 13311639313
- Fax
- +86-21-34979012
- sales@shyrchem.com
- Country
- China
- ProdList
- 806
- Advantage
- 55
- Tel
- 0523-86818997 18652728585
- sales@allyrise.com
- Country
- China
- ProdList
- 2966
- Advantage
- 60
- Tel
- 028-87608726 13540107218
- Fax
- 028-87608725
- sales@cdclimb.com
- Country
- China
- ProdList
- 104
- Advantage
- 58
- Tel
- 0531-88803958 18866891188
- Fax
- 0531-82777287
- 18853169188@163.com
- Country
- China
- ProdList
- 193
- Advantage
- 58
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18333
- Advantage
- 56
- Tel
- 025-83172655 13585105703
- Fax
- +86-25-86501191
- sales@njfirstpharm.com
- Country
- China
- ProdList
- 110
- Advantage
- 60
- Tel
- 0519-83879978
- sales@ideaworkspharm.com
- Country
- China
- ProdList
- 85
- Advantage
- 62
- Tel
- 027-59207879 1972026995 18140587686
- Fax
- QQ：1972026995
- sales@3600chem.com
- Country
- China
- ProdList
- 4447
- Advantage
- 55
- Tel
- 18068075658
- Fax
- -
- sales@chempioneer.com
- Country
- China
- ProdList
- 1811
- Advantage
- 58
- Tel
- 0512-63009836 18994340901
- Fax
- 0512-63006936
- helen@struchem.com
- Country
- China
- ProdList
- 3981
- Advantage
- 60
- Tel
- 0514-80939770 13773367191
- Fax
- 0514-82664689
- yzqyyykj@163.com
- Country
- China
- ProdList
- 252
- Advantage
- 55
- Tel
- 021-58088081 Q2635253576
- Fax
- QQ3382968513
- hailey@shsendpharm.com
- Country
- China
- ProdList
- 2081
- Advantage
- 55
- Tel
- 021-38751876 15000076078
- Fax
- 021-50275764
- Info@rochipharma.com
- Country
- China
- ProdList
- 611
- Advantage
- 55
- Tel
- 0570-3081766 18357083060
- Fax
- 0570-3072337
- sales@qzamkbio.com
- Country
- China
- ProdList
- 1046
- Advantage
- 55
- Tel
- 0531-69959492 18366108822
- Fax
- 0531-69959492
- 85633700@qq.com
- Country
- China
- ProdList
- 79
- Advantage
- 55
- Tel
- 028-86040038 13980902949;
- Fax
- 028-85149890
- market@dingdangchem.com
- Country
- China
- ProdList
- 1853
- Advantage
- 55
- Tel
- +86-28-85182370
- Fax
- +86-28-85182370
- info@zepletech.com
- Country
- China
- ProdList
- 20
- Advantage
- 58
- Tel
- 526763801 13301653310
- Fax
- +86-21-51619052
- 526763801@qq.com
- Country
- China
- ProdList
- 9274
- Advantage
- 55
- Tel
- 18866895588
- Fax
- 0531-82777287
- dingjiaying@shiningpharm.com
- Country
- China
- ProdList
- 163
- Advantage
- 55
- Tel
- 021-61312847; 18021002903
- Fax
- QQ:3008007432
- 3008007409@qq.com
- Country
- China
- ProdList
- 71826
- Advantage
- 60
- Tel
- 02781293128
- orders@biochemsafebuy.com
- Country
- China
- ProdList
- 9923
- Advantage
- 55
- Tel
- 0317-5296180 15533709196
- Fax
- 0317-5106596
- sale@enkepharma.com
- Country
- China
- ProdList
- 2267
- Advantage
- 55
- Tel
- Fax
- -
- 13006575422@163.com
- Country
- China
- ProdList
- 6355
- Advantage
- 58
- Tel
- 0371-0371-55629727 13323845623
- Fax
- 037155629727
- 2885676761@qq.com
- Country
- China
- ProdList
- 10110
- Advantage
- 58
- Tel
- 0531-69959492 18560053868
- Fax
- 0531-88603458
- 85349064@qq.com
- Country
- China
- ProdList
- 144
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-66162170
- Fax
- 025-66162170
- Country
- China
- ProdList
- 7181
- Advantage
- 55
- Tel
- 027-50664929, 13971561712
- Fax
- 027-50664927 / QQ: 3452835437
- hubxys2001@163.com
- Country
- China
- ProdList
- 1437
- Advantage
- 55
- Tel
- 027-027-65526929 15102793023
- Fax
- 027-65526669
- hbhxry@foxmail.com
- Country
- China
- ProdList
- 1786
- Advantage
- 55
- Tel
- 0551-68936860-8515 15357955825
- Fax
- 0551-68936860
- 15357955825@163.com
- Country
- China
- ProdList
- 81
- Advantage
- 55
- Tel
- 028-85255396 18302801538
- Fax
- 028-85255396
- cdnovell@163.com
- Country
- China
- ProdList
- 2389
- Advantage
- 58
- Tel
- 0531-82812892
- Fax
- 0531-82812892
- sunshinepharm0531@163.com
- Country
- China
- ProdList
- 39
- Advantage
- 58
- Tel
- 0512-0512-62793604 18015430729
- Fax
- 0512-62793604
- 116667374@qq.com
- Country
- China
- ProdList
- 127
- Advantage
- 58
- Tel
- +86-（0）57185586718; +8613336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29735
- Advantage
- 60
- Tel
- 025-66061636 18013972705
- Fax
- (3)02557626880
- qqyang@aikonchem.com
- Country
- China
- ProdList
- 15814
- Advantage
- 58
- Tel
- 027-83778895 18602735115
- Fax
- 027-51119224
- 18602735115@163.com
- Country
- China
- ProdList
- 2005
- Advantage
- 64
- Tel
- 027-87466105 15377573527
- 2678564200@qq.com
- Country
- China
- ProdList
- 17987
- Advantage
- 58
- Tel
- 021-60345187 13917602471
- Fax
- 021-60345187
- lzz841106@aliyun.com
- Country
- China
- ProdList
- 510
- Advantage
- 58
- Tel
- 400-8210725 400821072
- Fax
- 021-58955996
- malulu@leyan.com
- Country
- China
- ProdList
- 25000
- Advantage
- 58
- Tel
- 021-37199966 13681836088
- Fax
- 021-37597788
- bj@bj-chem.com
- Country
- China
- ProdList
- 463
- Advantage
- 58
- Tel
- Fax
- -
- jnyaoyan@163.com
- Country
- China
- ProdList
- 3069
- Advantage
- 58
- Tel
- 0371-55051623 18137891487
- Fax
- QQ：2853979817
- 2853979817@qq.com
- Country
- China
- ProdList
- 9984
- Advantage
- 58
- Tel
- 13370351217 kungfu1217@1
- Fax
- QQ1400885609
- kungfu1217@163.com
- Country
- China
- ProdList
- 2720
- Advantage
- 58
- Tel
- 15966937598
- Fax
- 3407640895 3071519937
- 3407650895@qq.com
- Country
- China
- ProdList
- 2274
- Advantage
- 58
More
Less
View Lastest Price from Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate 205448-65-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-30
Nanjing Fred Technology Co., Ltd
- Product
- methyl 7-methoxy-4-oxo-1,4-dihy-droquinoline-6-carboxylate 205448-65-3
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-19
Career Henan Chemical Co
- Product
- Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate 205448-65-3
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-07-31
205448-65-3, Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylateRelated Search:
phenyl 2-chloro-4-hydroxyphenylcarbaMate
4-Amino-3-chlorophenol hydrochloride
lenvatinib Mesylate
Methyl 4-chloro-7-Methoxyquinoline-6-carboxylate
4-Amino-3-chlorophenol
4-chloro-7-Methoxyquinoline-6-carboxaMide
Lenvatinib
METHYL 4-CHLORO-3-FLUOROBENZOATE
METHYL 5-BROMO-6-HYDROXYNICOTINATE
METHYL PHOSPHORODICHLORIDATE
Lenvatinib Impurity 28
3-Chlorophenol
CYCLOPROPANECARBOXAMIDE
1,3-dicyclopropylurea
Methyl cyclopropane carboxylate
Diphenyl carbonate
4-AMINO-2-METHOXYBENZOIC ACID
Phenol, 3-chloro-4-(2-phenyldiazenyl)-