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isofebrifugin

Product Name
isofebrifugin
CAS No.
32434-44-9
Chemical Name
isofebrifugin
Synonyms
NSC 290495;isoferifugine;isofebrifugin;Isofebrifugine;cis-Febrifugine;alpha-Dichroine;ISOFEBRIFUGINE (B604866K055);Isofebrifugine, 10 mM in DMSO;3-[[(3aS,7aS)-Octahydro-2-hydroxyfuro[3,2-b]pyridin-2-yl]methyl]-4(3H)-quinazolinone;3-[(3aS,7aS)-2-Hydroxyperhydrofuro[3,2-b]pyridin-2-ylmethyl]-3,4-dihydroquinazolin-4-one
CBNumber
CB32715446
Molecular Formula
C16H19N3O3
Formula Weight
301.34
MOL File
32434-44-9.mol
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isofebrifugin Property

Melting point:
129-130 °C
Boiling point:
519.8±58.0 °C(Predicted)
Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Solid
pka
12.01±0.20(Predicted)
color 
White to off-white
InChI
InChI=1S/C16H19N3O3/c20-15-11-4-1-2-5-12(11)18-10-19(15)9-16(21)8-13-14(22-16)6-3-7-17-13/h1-2,4-5,10,13-14,17,21H,3,6-9H2/t13-,14-,16-/m0/s1
InChIKey
YLYLCQRQSRDSQR-DZKIICNBSA-N
SMILES
N1C2=C(C=CC=C2)C(=O)N(C[C@@]2(O)O[C@@]3([H])CCCN[C@@]3([H])C2)C=1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Usbiological
Product number
300478
Product name
ISOFEBRIFUGINE
Packaging
20mg
Price
$665
Updated
2021/12/16
Biorbyt Ltd
Product number
orb259322
Product name
ISOFEBRIFUGINE (B604866K055)
Purity
98%
Packaging
20mg
Price
$666.4
Updated
2021/12/16
ChemScene
Product number
CS-0032113
Product name
Isofebrifugine
Packaging
5mg
Price
$336
Updated
2021/12/16
Biorbyt Ltd
Product number
orb259322
Product name
ISOFEBRIFUGINE (B604866K055)
Purity
98%
Packaging
10mg
Price
$513.4
Updated
2021/12/16
ChemScene
Product number
CS-0032113
Product name
Isofebrifugine
Packaging
10mg
Price
$571
Updated
2021/12/16
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isofebrifugin Chemical Properties,Usage,Production

Chemical Properties

White powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the dried root of Dichroa febrifuga Lour.

Uses

Isofebrifugine is a natural quinazolinone alkaloid with important physiological activities and good pharmacological effects. Antimalarial effect[1].

References

[1] Kobayashi S, et al. Catalytic Asymmetric Synthesis of Antimalarial Alkaloids Febrifugine and Isofebrifugine and Their Biological Activity.J Org Chem. 1999 Sep 3;64(18):6833-6841. DOI:10.1021/jo990877k

isofebrifugin Preparation Products And Raw materials

Raw materials

Preparation Products

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32434-44-9, isofebrifuginRelated Search:


  • isofebrifugin
  • Isofebrifugine
  • 3-[[(3aS,7aS)-Octahydro-2-hydroxyfuro[3,2-b]pyridin-2-yl]methyl]-4(3H)-quinazolinone
  • alpha-Dichroine
  • cis-Febrifugine
  • NSC 290495
  • ISOFEBRIFUGINE (B604866K055)
  • 3-[(3aS,7aS)-2-Hydroxyperhydrofuro[3,2-b]pyridin-2-ylmethyl]-3,4-dihydroquinazolin-4-one
  • 4(3H)-Quinazolinone, 3-[[(2S,3aS,7aS)-octahydro-2-hydroxyfuro[3,2-b]pyridin-2-yl]methyl]-
  • isoferifugine
  • Isofebrifugine, 10 mM in DMSO
  • 32434-44-9