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Febrifugine

Product Name
Febrifugine
CAS No.
24159-07-7
Chemical Name
Febrifugine
Synonyms
febrifugin;ferifugine;β-dichroine;Febrifugine;Radix Dichroae;(+)-Febrifugine;BETA-Febrifugine;Febrifugine USP/EP/BP;Febrifugine,Isofebrifugine;Febrifugine (6-Desoxyswietenine)
CBNumber
CB11178705
Molecular Formula
C16H19N3O3
Formula Weight
301.34
MOL File
24159-07-7.mol
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Febrifugine Property

Melting point:
139-140°; mp 154-156°
alpha 
D25 +6° (c = 0.5 in chloroform); D25 +28° (c = 0.5 in ethanol)
Density 
1.39
storage temp. 
2-8°C
solubility 
DMF: 1.5 mg/ml; DMSO: 3.0 mg/ml; Ethanol: 0.1 mg/ml; PBS (pH 7.2): 2.5 mg/ml
form 
A crystalline solid
Boiling point:
508.2±60.0 °C(Predicted)
pka
14.61±0.40(Predicted)
color 
White to off-white
CAS DataBase Reference
24159-07-7
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Safety

Toxicity
LD50 orally in white mice: 2.5-3.0 mg/kg (Koepfli, 1949)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
14246
Product name
Febrifugine
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
14246
Product name
Febrifugine
Packaging
5mg
Price
$169
Updated
2024/03/01
Usbiological
Product number
300268
Product name
Febrifugine
Packaging
20mg
Price
$665
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0003303
Product name
3-[3-[3(S)-HYDROXYPIPERIDIN-2(R)-YL]-2-OXOPROPYL]-3,4-DIHYDROQUINAZOLIN-4-ONE
Purity
95.00%
Packaging
1G
Price
$3854.55
Updated
2021/12/16
ChemScene
Product number
CS-0022587
Product name
Febrifugine
Packaging
5mg
Price
$336
Updated
2021/12/16
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Febrifugine Chemical Properties,Usage,Production

Description

Febrifugine is a quinazolinone alkaloid originally isolated from D. febrifuga that has antimalarial activity. It reduces parasitemia and decreases mortality in mice infected with the P. berghei strain NK65 when administered at a dose of 1 mg/kg per day beginning prior to or on the day of infection.

Uses

Febrifugine is a quinazoline alkaloid with significant antimalarial and anticancerous efficacy. Febrifugine is an NRF2 inhibitor, that works with halofuginone for the treatment of chemo- and radio-resistant forms of cancer. Febrifugine analogs also functions as antimalarial, anticancer agents and in the prevention of chicken coccidiosis.

Febrifugine Preparation Products And Raw materials

Raw materials

Preparation Products

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Febrifugine Suppliers

Huzhou ZhanShu Biotechnology Co.,Ltd
Tel
0572-8889530 18167260939
Email
zsubio@163.com
Country
China
ProdList
357
Advantage
58
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
Chengdu Herbpurify Co.Ltd.
Tel
18302802153 18981717076
Fax
086-28-85377358
Email
2355253619@qq.com
Country
China
ProdList
1104
Advantage
58
Shanghai Union Resource Chemistry Co., Ltd
Tel
021-50454025 18930054025
Fax
021-50454025
Country
China
ProdList
103
Advantage
58
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
Country
China
ProdList
9649
Advantage
58
Shanghai Aspire Biological Technology Co., Ltd.
Tel
021-61317773
Fax
021-61486878
Email
sales@aspirebio.com
Country
China
ProdList
2880
Advantage
58
Shanghai Yongye Biotechnology Co., Ltd.
Tel
86-021-61559134 15921386130
Fax
021-55068248
Email
3423497944@qq.com
Country
China
ProdList
8144
Advantage
55
Wuhan ChemFaces Biochemical Co., Ltd.
Tel
18607101326 15172504745
Fax
+86-27-84254680
Email
aileen@chemfaces.com
Country
China
ProdList
7059
Advantage
55
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
27313
Advantage
60
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View Lastest Price from Febrifugine manufacturers

Career Henan Chemical Co
Product
Febrifugine 24159-07-7
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-09

24159-07-7, FebrifugineRelated Search:


  • Febrifugine
  • β-dichroine
  • 3-(3-(3-Hydroxypiperidin-2-yl)-2-oxopropyl)quinazolin-4(3H)-one
  • Febrifugine,Isofebrifugine
  • 3-[3-[(2R,3S)-3-Hydroxy-2-piperidinyl]-2-oxopropyl]-4(3H)-quinazolinone
  • BETA-Febrifugine
  • febrifugin
  • 4(3H)-Quinazolinone, 3-[3-[(2R,3S)-3-hydroxy-2-piperidinyl]-2-oxopropyl]-
  • Radix Dichroae
  • Febrifugine (6-Desoxyswietenine)
  • Febrifugine USP/EP/BP
  • ferifugine
  • (+)-Febrifugine
  • 24159-07-7