Eriocalyxin B
- Product Name
- Eriocalyxin B
- CAS No.
- 84745-95-9
- Chemical Name
- Eriocalyxin B
- Synonyms
- Eriocalyxin B;5-trimethoxyphenol;Eriocalyxin B, 10 mM in DMSO;Kaura-2,16-diene-1,15-dione, 7,20-epoxy-6,7-dihydroxy-, (6β,7α)-;(4aR,5S,6S,6aS,9R,11aS,11bS)-5,6-Dihydroxy-4,4-dimethyl-8-methylene-4,4a,5,6,9,10,11,11a-octahydro-1H-6,11b-(epoxymethano)-6a,9-methanocyclohepta[a]naphthalene-1,7(8H)-dione
- CBNumber
- CB52519723
- Molecular Formula
- C20H24O5
- Formula Weight
- 344.41
- MOL File
- 84745-95-9.mol
Eriocalyxin B Property
- Boiling point:
- 551.1±50.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- pka
- 11.05±0.60(Predicted)
- form
- Solid
- color
- White to off-white
- InChIKey
- RTIKCEKESDRWAE-HCLRZYKANA-N
- SMILES
- O[C@@]12OC[C@]3(C(C=CC(C)(C)[C@@]3([H])[C@@H]1O)=O)[C@]1([H])CC[C@@]3([H])C(=C)C(=O)[C@@]21C3 |&1:1,4,11,13,16,20,26,r|
N-Bromosuccinimide Price
- Product number
- CFN97402
- Product name
- EriocalyxinB
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $593
- Updated
- 2021/12/16
- Product number
- CD32000271
- Product name
- EriocalyxinB
- Purity
- 95+%
- Packaging
- 5mg
- Price
- $810
- Updated
- 2021/12/16
Eriocalyxin B Chemical Properties,Usage,Production
Uses
Eriocalyxin B is an ent-Kaurene diterpenoid isolated from Chinese herb Isodon eriocalyx. Eriocalyxin B has anti-cancer and anti-infammatory activities. Eriocalyxin B induces cell apoptosis[1].
References
[1] Rong-Fang Mu, et al. Eriocalyxin B Inhibits Adipogenesis in 3T3-L1 Adipocytes by Cell Cycle Arrest. Nat Prod Bioprospect. 2020 Jun;10(3):131-140. DOI:10.1007/s13659-020-00240-6
[2] Wang WG, et al. Laxiflorolides A and B, epimeric bishomoditerpene lactones from Isodon eriocalyx. J Nat Prod. 2012 Jun 22;75(6):1102-7.
[3] Zhou X, et al. Eriocalyxin B, a novel autophagy inducer, exerts anti-tumor activity through the suppression of Akt/mTOR/p70S6K signaling pathway in breast cancer. Biochem Pharmacol. 2017 Oct 15;142:58-70.
[4] Lu Y, et al. Eriocalyxin B ameliorates experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2258-63.
[5] Leung CH, et al. Eriocalyxin B inhibits nuclear factor-kappaB activation by interfering with the binding of both p65 and p50 to the response element in a noncompetitive manner. Mol Pharmacol. 2006 Dec;70(6):1946-55.Leung CH, Grill SP, Lam W, Gao W, Sun HD, Cheng YC. Eriocalyxin B inhibits nuclear factor-kappaB activation by interfering with the binding of both p65 and p50 to the response element in a noncompetitive manner. Mol Pharmacol. 2006 Dec;70(6):1946-55.
Eriocalyxin B Preparation Products And Raw materials
Raw materials
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