ChemicalBook > CAS DataBase List > KukoaMine B
KukoaMine B
- Product Name
- KukoaMine B
- CAS No.
- 164991-67-7
- Chemical Name
- KukoaMine B
- Synonyms
- Geoscutin;KukoaMine B;Kukoamine B-D8;Kukoamine B DiHCl;Resorcinol Impurity 30;Dihydroxybenzenepropanamide;N-(3-Aminopropyl)-3-(3,4-dihydroxyphenyl)-N-(4-((3-(3-(3,4-dihydroxyphenyl)propanamido)propyl)amino)butyl)propanamide;Benzenepropanamide,N-(3-aminopropyl)-N-[4-[[3-[[3-(3,4-dihydroxyphenyl)-1-oxopropyl]amino]propyl]amino]butyl]-3,4-dihydroxy-
- CBNumber
- CB82602352
- Molecular Formula
- C28H42N4O6
- Formula Weight
- 530.66
- MOL File
- 164991-67-7.mol
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KukoaMine B Property
- Boiling point:
- 844.3±65.0 °C(Predicted)
- Density
- 1.232±0.06 g/cm3 (20 ºC 760 Torr)
- storage temp.
- -20°C
- solubility
- DMF:30.0(Max Conc. mg/mL);56.53(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);56.53(Max Conc. mM)
Ethanol:30.0(Max Conc. mg/mL);56.53(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);18.84(Max Conc. mM)
Water:62.5(Max Conc. mg/mL);117.78(Max Conc. mM) - form
- A crystalline solid
- pka
- 9.78±0.10(Predicted)
- color
- White to off-white
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 21091
- Product name
- Kukoamine B
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21091
- Product name
- Kukoamine B
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $120
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21091
- Product name
- Kukoamine B
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $188
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21091
- Product name
- Kukoamine B
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $384
- Updated
- 2024/03/01
TRC
- Product number
- K660440
- Product name
- KukoamineB
- Packaging
- 5mg
- Price
- $105
- Updated
- 2021/12/16
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KukoaMine B Chemical Properties,Usage,Production
Uses
Kukoamine B is an amide alkaloiad used in the protection against NMDA-induced neurotoxicity and potential harmful mechanisms. In addition it is seen to inhibit the inflammatory response in the livers of septic mice.
Definition
ChEBI: Kukoamine B is an amine.
in vivo
Kukoamine B (20, 50 mg/kg, i.g., daily, 9 weeks) reduces inflammation and blood glucose without body weight gain or liver mass increase[1].
Kukoamine B (2, 5 mg/kg, p.o., daily, 12 weeks) demonstrates the anti-osteoporotic effects in ovariectomized (OVX) mice[3].
Kukoamine B (1.25-60 mg/kg, i.v., only one injection or very 8 h for 3 days) protects mice challenged with E. coli and reduces the circulatory levels of LPS and TNF-a in sepsis model mice[4].
| Animal Model: | Male, 4-week old db/db mice (BKS.Cgm+/+Leprdb/J) and wildtype (WT) mice (C57BLKS/J-m+/+ db). A spontaneous type 2 diabetic animal model[1]. |
| Dosage: | 20, 50 mg/kg |
| Administration: | i.g., daily, 9 weeks |
| Result: | Successfully controlled the augment of blood glucose with age increase. Reduced levels of 29 inflammatory markers such as IL-2, IL-3, IL-4, IL-5, IL-6, IL-7 and IL8. |
| Animal Model: | Seven-week-old female ddy mice underwent either an ovariectomy or sham-operated surgery[3]. |
| Dosage: | 2, 5 mg/kg |
| Administration: | p.o., daily, 12 weeks |
| Result: | Inhibited the OVX-induced BMD loss in the right femur bone and restored the impaired bone structural properties of BV/TV, Tb.Th, Tb.N, and Tb.Sp. |
| Animal Model: | Kunming (KM) mice, 4–6 weeks old, 18–20 g, male and female in equal number. Mice were injected with heat-killed E. coli (EC, 1.0 * 1011 CFU?kg-1) in order to establish the sepsis model.[4]. |
| Dosage: | 1.25, 2.5, 5, 10, 15, 30, 60 mg/kg |
| Administration: | 80 mice (15, 30, 60 mg/kg), i.v., only one injection; 100 mice (1.25, 2.5, 5 mg/kg), i.v., every 8 h for 3 days; 96 mice, (60 mg/kg), i.v., once at 0, 2, 4, 6, 8 h after injection of EC. |
| Result: | Significantly decreased the mortality rate from 87.5% to 62.5%, 62.5%, or 37.5% (15, 30, 60 mg/kg). Decreased the mortality rate from 95% to 65%, 60% and 45% (1.25, 2.5 and 5 mg/kg). Decreased the circulatory LPS and TNF-a levels in a time-dependent manner. |
KukoaMine B Preparation Products And Raw materials
Raw materials
Preparation Products
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KukoaMine B Suppliers
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- 0791-82165230 17707911324
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- China
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- Country
- United States
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View Lastest Price from KukoaMine B manufacturers
Career Henan Chemical Co
- Product
- Kukoamine B 164991-67-7
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1kg,5kg,50kg
- Release date
- 2020-01-18
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