kukoamine A

Product Name: kukoamine A
CAS No.: 75288-96-9
Chemical Name: kukoamine A
Synonyms: NSC5398;NSC 5398;NSC-5398;kukoamine A;1,14-Bis(dihydrocaffeoyl)spermidine;N1,N12-Bis(dihydrocaffeoyl) spermine;N,N'-[Tetramethylenebis(iminotrimethylene)]bis[3-(3,4-dihydroxyphenyl)propionamide];N,N'-[1,4-Butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxybenzenepropanamide];Benzenepropanamide,N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxy-;N,N'-((butane-1,4-diylbis(azanediyl))bis(propane-3,1-diyl))bis(3-(3,4-dihydroxyphenyl)propanamide)
CBNumber: CB21355400
Molecular Formula: C28H42N4O6
Formula Weight: 530.66
MOL File: 75288-96-9.mol

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kukoamine A Property

Boiling point:: 872.1±65.0 °C(Predicted)
Density: 1.213±0.06 g/cm3 (20 ºC 760 Torr)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
form: A crystalline solid
pka: 9.48±0.10(Predicted)
color: Off-white to yellow
CAS DataBase Reference: 75288-96-9

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL83866
Product name: Kukoamine A
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $688
Updated: 2024/03/01

Cayman Chemical

Product number: 25139
Product name: Kukoamine A
Purity: ≥95%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 25139
Product name: Kukoamine A
Purity: ≥95%
Packaging: 5mg
Price: $176
Updated: 2024/03/01

Cayman Chemical

Product number: 25139
Product name: Kukoamine A
Purity: ≥95%
Packaging: 10mg
Price: $330
Updated: 2024/03/01

Usbiological

Product number: 300534
Product name: Kukoamine A
Packaging: 10mg
Price: $618
Updated: 2021/12/16

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kukoamine A Chemical Properties,Usage,Production

Description

Kukoamine A is a spermine alkaloid originally isolated from L. chinense that has diverse biological activities, including anticancer, neuroprotective, and anti-inflammatory properties. Kukoamine A (5-20 μg/ml) inhibits colony formation of U251 and WJ1 glioblastoma cells in a concentration-dependent manner. It halts the cell cycle at the G₀/G₁ phase and induces apoptosis when used at concentrations of 60 and 80 μg/ml. Kukoamine A (20 and 40 μM) induces autophagy and increases cell viability in an SH-SY5Y cell model of MPP-induced injury. It increases the number of dopamine neurons in the substantia nigra and striatum, decreases α-synuclein expression, and improves motor function in an MPTP mouse model of Parkinson’s disease when administered at a dose of 20 mg/kg per day. Kukoamine A (10 and 20 mg/kg) decreases IL-1β, TNF-α, and COX-2 protein levels in the hippocampus and increases hippocampal neurogenesis in a rat model of radiation injury. It also selectively inhibits trypanothione reductase (K_i = 1.8 μM), an enzyme that protects certain parasites from oxidative stress, over human glutathione reductase (K_i = >10 mM).

Occurrence

The root bark of Lychium chinense yields this alkaloid. Kukoamine A possesses hypotensive activity inducing hypotension in rats at a dose of 5 mg/kg when given intravenously.

Uses

Kukoamine A is a neuroprotective agent which is used to prevent the loss of dopaminergic neurons in substantia nigra.

Definition

ChEBI: Kukoamine A is an amine.

kukoamine A Preparation Products And Raw materials

Raw materials

Preparation Products

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kukoamine A Suppliers

China 89 United Kingdom 1 United States 7 Global 97

Shanghai YuanYe Biotechnology Co., Ltd.

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Wuhan ChemFaces Biochemical Co., Ltd.

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EMMX Biotechnology LLC

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Shandong Xiya Chemical Co., Ltd.

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Country: China
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View Lastest Price from kukoamine A manufacturers

Career Henan Chemical Co

Product: kukoamine A 75288-96-9
Price: US $8.00/KG
Min. Order: 1g
Purity: ＞98% HPLC
Supply Ability: kg--ton
Release date: 2020-02-20

75288-96-9, kukoamine ARelated Search:

Triptolide Xanthiside VERATRIDINE L-Hyoscyamine Xanthiazone Daurinoline 2-[2-(Methylamino)benzoyl]-3,4-dihydro-β-carboline-1(2H)-one menisdaurin daurisoline veratramine VERATRINE 1,3-Dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone Tributyl citrate (-)-Huperzine A CALYCOSIN KukoaMine B Spermidine

kukoamine A

1,14-Bis(dihydrocaffeoyl)spermidine

N,N'-[1,4-Butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxybenzenepropanamide]

N,N'-[Tetramethylenebis(iminotrimethylene)]bis[3-(3,4-dihydroxyphenyl)propionamide]

N1,N12-Bis(dihydrocaffeoyl) spermine

Benzenepropanamide,N,N'-[1,4-butanediylbis(imino-3,1-propanediyl)]bis[3,4-dihydroxy-

N,N'-((butane-1,4-diylbis(azanediyl))bis(propane-3,1-diyl))bis(3-(3,4-dihydroxyphenyl)propanamide)

NSC 5398

NSC5398

NSC-5398

75288-96-9