ChemicalBook > CAS DataBase List > 1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
- Product Name
- 1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
- CAS No.
- 114262-49-6
- Chemical Name
- 1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
- Synonyms
- Sofosbuvir metabolites GS331007;Sofosbuvir Methylarabinosyl Impurity;Hydroxyuridine/Sofosbuvir Impurity 12;1-β-D-Arabinofuranosyluracil-2-C-methyl;1-(2'-C-methyl-β-D-arabinofuranosyl)uracil;1-(2-C-Methyl-β-D-arabinofuranosyl)-2,4(1H,3H)-pyrimidinedione;2,4(1H,3H)-Pyrimidinedione, 1-(2-C-methyl-β-D-arabinofuranosyl)-;1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione
- CBNumber
- CB32715875
- Molecular Formula
- C10H14N2O6
- Formula Weight
- 258.23
- MOL File
- 114262-49-6.mol
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1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione Property
- Melting point:
- 132-135 °C
- Density
- 1.572±0.06 g/cm3(Predicted)
- pka
- 9.39±0.10(Predicted)
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N-Bromosuccinimide Price
TRC
- Product number
- A764005
- Product name
- 1-β-D-Arabinofuranosyluracil-2-C-methyl
- Packaging
- 25mg
- Price
- $165
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-M2827
- Product name
- 1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
- Packaging
- 5mg
- Price
- $1500
- Updated
- 2021/12/16
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1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione Chemical Properties,Usage,Production
Uses
1-β-D-Arabinofuranosyluracil-2-C-methyl is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dione Suppliers
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114262-49-6, 1-((2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-3-Methyltetrahydrofuran-2-yl)pyriMidine-2,4(1H,3H)-dioneRelated Search:
Sofosbuvir
SofosBuvir Impurity 14
SofosBuvir Impurity 52
PSI-7976
2'-deoxy-2'-fluoro-2'-C-methyluridine
SofosBuvir Impurity 50
(S)-methyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate
Sofosbuvir Impurity23
Sofosbuvir impurity I
Sofosbuvir IMpurity C 1337482-15-1
SofosBuvir Impurity 39
1-((2S,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-3-methyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
sofosBuvir impurity 1
Sofosbuvir Impurity25
Sofosbuvir Impurity 5
Sofosbuvir metabolites
D-Alanine, N-[[P(R),2'R]-2'-deoxy-2'-fluoro-2'-Methyl-P-phenyl-5'-uridylyl]-, 1-Methylethyl ester
SofosBuvir impurity 44