MPI-0479605
- Product Name
- MPI-0479605
- CAS No.
- 1246529-32-7
- Chemical Name
- MPI-0479605
- Synonyms
- CS-1459;MPI-0479605;MPI0479605 HCl;MPI-0479605 USP/EP/BP;MPI-0479605;MPI 0479605;MPI0479605;N6-cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine;N6-Cyclohexyl-N2-[2-methyl-4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine;9H-?Purine-?2,?6-?diamine, N6-?cyclohexyl-?N2-?[2-?methyl-?4-?(4-?morpholinyl)?phenyl]?-
- CBNumber
- CB32731101
- Molecular Formula
- C22H29N7O
- Formula Weight
- 407.51
- MOL File
- 1246529-32-7.mol
MPI-0479605 Property
- Boiling point:
- 745.8±70.0 °C(Predicted)
- Density
- 1.318±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- Soluble in DMSO
- form
- A crystalline solid
- pka
- 10.52±0.10(Predicted)
- color
- White to gray
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 22136
- Product name
- MPI-0479605
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 22136
- Product name
- MPI-0479605
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $233
- Updated
- 2024/03/01
- Product number
- 22136
- Product name
- MPI-0479605
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $437
- Updated
- 2024/03/01
- Product number
- 22136
- Product name
- MPI-0479605
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $957
- Updated
- 2024/03/01
- Product number
- 2574AH
- Product name
- N6-Cyclohexyl-N2-(2-methyl-4-morpholinophenyl)-9H-purine-2,6-diamine
- Packaging
- 1g
- Price
- $1246
- Updated
- 2021/12/16
MPI-0479605 Chemical Properties,Usage,Production
Description
MPI-0479605 is a potent and ATP-competitive inhibitor of the mitotic kinase MPS1 (IC50 = 1.8 nM). It is selective for MPS1 over a panel of 79 kinases at a concentration of 500 nM. MPI-0479605 induces time-dependent degradation of cyclin B and securin and decreases phosphorylation of BUBR1 resulting in failed cytokinesis in HeLa cells arrested by nocodazole . It also causes misalignment of chromosomes at the anaphase plate and aneuploidy in A549 cells and slows cell cycle progression of HCT116 and COLO 205 cells irrespective of p53 activity. MPI-0479605 (30-150 mg/kg) reduces tumor volume in an HCT116 mouse colon cancer xenograft model in a dose-dependent manner.
References
[1] tardif k d, rogers a, cassiano j, et al. characterization of the cellular and antitumor effects of mpi-0479605, a small-molecule inhibitor of the mitotic kinase mps1. molecular cancer therapeutics, 2011, 10(12): 2267-2275.
MPI-0479605 Preparation Products And Raw materials
Raw materials
Preparation Products
MPI-0479605 Suppliers
- Tel
- 44-20819178-90 02081917890
- Fax
- (0)2080432064
- info@novachemistry.com
- Country
- United Kingdom
- ProdList
- 4381
- Advantage
- 58
View Lastest Price from MPI-0479605 manufacturers
- Product
- MPI-0479605 1246529-32-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2019-12-25