BD 1047 dihydrobromide
- Product Name
- BD 1047 dihydrobromide
- CAS No.
- 138356-21-5
- Chemical Name
- BD 1047 dihydrobromide
- Synonyms
- 169592;BD1047.2HBr;BD 1047 HBr;BD-1047;BD 1047;BD1047.2HBr(1K/g);BD 1047 (hydrobromide);BD 1047 dihydrobromide, sigma1 receptor antagonist;N1-(3,4-DICHLOROPHENETHYL)-N1,N2,N2-TRIMETHYLETHANE-1,2-DIAMINE 2HBR;N1-(3,4-dichlorophenethyl)-N1,N2,N2-trimethylethane-1,2-diamine dihydrobromide;N-[2-(3,4-Dichlorophenyl)ethyl]-N,N',N'-trimethyl-1,2-ethanediamine dihydrobromide
- CBNumber
- CB32755978
- Molecular Formula
- C13H22Br2Cl2N2
- Formula Weight
- 437.04118
- MOL File
- 138356-21-5.mol
BD 1047 dihydrobromide Property
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- H2O: >5mg/mL
- form
- powder
- color
- white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- B8562
- Product name
- BD 1047 dihydrobromide
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $114
- Updated
- 2024/03/01
- Product number
- B8562
- Product name
- BD 1047 dihydrobromide
- Purity
- ≥95% (HPLC)
- Packaging
- 25mg
- Price
- $449
- Updated
- 2024/03/01
- Product number
- 22928
- Product name
- BD 1047 (hydrobromide)
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 22928
- Product name
- BD 1047 (hydrobromide)
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 22928
- Product name
- BD 1047 (hydrobromide)
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $235
- Updated
- 2024/03/01
BD 1047 dihydrobromide Chemical Properties,Usage,Production
Description
BD 1047 is a selective antagonist of sigma-1 (σ1) receptors (Ki = 0.9 nM in a radioligand binding assay). It is selective for σ1 receptors with binding affinity values greater than 10,000 nM for human recombinant dopamine, opioid, PCP, and serotonin receptors in vitro. In vivo, pretreatment with BD 1047 protects against convulsions and lethality induced by cocaine (Item Nos. 16186 | ISO60176) and reduces cocaine-induced locomotor activity. It reduces dystonias induced by the σ receptor agonists haloperidol and di-o-tolylguanidine (DTG) in rats in a dose-dependent manner. In vivo administration of BD 1047 also attenuates mechanical allodynia and microglial activation in a rat model of bone cancer pain.
Uses
BD 1047 dihydrobromide is an σ1 receptor antagonist with higher affinity than BD 1063.
storage
Desiccate at +4°C
References
1) Matsumoto?et al.?(1995),?Characterization of two novel σ receptor ligands: antidystonic effects in rats suggest σ receptor antagonism; Eur. J. Pharmacol.?280?301 2) McCracken?et al.?(1999),?Two novel sigma receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity; Eur. J. Pharmacol.?370?225 3) Song?et al.?(2017),?Role of sigma 1 receptor in high fat diet-induced peripheral neuropathy; Biol. Chem.?398?1141 4) Jeong?et al. (2005),?The spinal antinociceptive mechanism determined by systemic administration of BD1047 in zymosan-induced hyperalgesia in rats; Brain Res. Bull.?119(Pt.A) 93 5) Roh and Yoon (2014),?Sigma-1 receptor antagonist BD1047 reduces nociceptive response and phosphorylation of p38 MAPK in mice orofacial formalin model; Biol. Pharm. Bull.?37?145 6) Zhu?et al.?(2015),?Sigma-1 Receptor Antagonist BD1047 Reduces Mechanical Allodynia in a Rat Model of Bone Cancer Pain through the Inhibition of Spinal NR1 Phosphorylation and Microglia Activation; Mediators Inflamm.?2015?265056
BD 1047 dihydrobromide Preparation Products And Raw materials
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View Lastest Price from BD 1047 dihydrobromide manufacturers
- Product
- BD 1047 dihydrobromide 138356-21-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2019-12-30