ChemicalBook > CAS DataBase List > diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate

diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate

Product Name
diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate
CAS No.
120533-76-8
Chemical Name
diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate
Synonyms
BML-278;BML278|||BML 278;BML-278, SIRT activator;DI ETHYL 1 BENZYL 4 PHENYL 4H PYRIDINE 3-5 DICARBOXYLATE;Diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate;diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-phenyl-1-(phenylmethyl)-, 3,5-diethyl ester
CBNumber
CB33050728
Molecular Formula
C24H25NO4
Formula Weight
391.46
MOL File
120533-76-8.mol
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diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate Property

Melting point:
139-141 °C(Solv: cyclohexane (110-82-7); benzene (71-43-2))
Boiling point:
525.5±50.0 °C(Predicted)
Density 
1.183±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Soluble in DMSO (up to 5 mg/ml).
form 
solid
pka
2.05±0.70(Predicted)
color 
Off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
20209
Product name
BML-278
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
20209
Product name
BML-278
Purity
≥95%
Packaging
5mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
20209
Product name
BML-278
Purity
≥95%
Packaging
10mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
20209
Product name
BML-278
Purity
≥95%
Packaging
25mg
Price
$305
Updated
2024/03/01
TRC
Product number
D441850
Product name
Diethyl1-Benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
Packaging
25mg
Price
$110
Updated
2021/12/16
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diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate Chemical Properties,Usage,Production

Description

BML-278 (120533-76-8) is a structurally novel activator of SIRT1 (EC50=1 μM). Displays selectivity over SIRT2 and 3 (EC50=25 and 50 μM respectively). Cell permeable.

Uses

Diethyl 1-Benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate is a cell-permeable and potent SIRT activator that induces cell cycle arrest. SIRT modulators have therapeutic potential the treatment of cancer, cardiovascular, metabolic, inflammatory, and neurodegenerative diseases.

Definition

ChEBI: 4-phenyl-1-(phenylmethyl)-4H-pyridine-3,5-dicarboxylic acid diethyl ester is a dihydropyridine.

References

1) Mai et al. (2009), Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors; J. Med.Chem.,52 5496

diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate Suppliers

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120533-76-8, diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylateRelated Search:

APICIDIN N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) SIRTINOL 2-N-HEXYL-4-PENTYNOIC ACID

  • diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate
  • DI ETHYL 1 BENZYL 4 PHENYL 4H PYRIDINE 3-5 DICARBOXYLATE
  • Diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
  • BML-278
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-phenyl-1-(phenylmethyl)-, 3,5-diethyl ester
  • BML278|||BML 278
  • BML-278, SIRT activator
  • 120533-76-8