diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate
- Product Name
- diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate
- CAS No.
- 120533-76-8
- Chemical Name
- diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate
- Synonyms
- BML-278;DI ETHYL 1 BENZYL 4 PHENYL 4H PYRIDINE 3-5 DICARBOXYLATE;Diethyl 1-benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate;diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-phenyl-1-(phenylmethyl)-, 3,5-diethyl ester
- CBNumber
- CB33050728
- Molecular Formula
- C24H25NO4
- Formula Weight
- 391.46
- MOL File
- 120533-76-8.mol
diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate Property
- Melting point:
- 139-141 °C(Solv: cyclohexane (110-82-7); benzene (71-43-2))
- Boiling point:
- 525.5±50.0 °C(Predicted)
- Density
- 1.183±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in DMSO (up to 5 mg/ml).
- form
- solid
- pka
- 2.05±0.70(Predicted)
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 20209
- Product name
- BML-278
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20209
- Product name
- BML-278
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $78
- Updated
- 2024/03/01
- Product number
- 20209
- Product name
- BML-278
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 20209
- Product name
- BML-278
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $305
- Updated
- 2024/03/01
- Product number
- D441850
- Product name
- Diethyl1-Benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate
- Packaging
- 25mg
- Price
- $110
- Updated
- 2021/12/16
diethyl 1-benzyl-1,4-dihydro-4-phenylpyridine-3,5-dicarboxylate Chemical Properties,Usage,Production
Description
BML-278 (120533-76-8) is a structurally novel activator of SIRT1 (EC50=1 μM). Displays selectivity over SIRT2 and 3 (EC50=25 and 50 μM respectively). Cell permeable.
Uses
Diethyl 1-Benzyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate is a cell-permeable and potent SIRT activator that induces cell cycle arrest. SIRT modulators have therapeutic potential the treatment of cancer, cardiovascular, metabolic, inflammatory, and neurodegenerative diseases.
Definition
ChEBI: 4-phenyl-1-(phenylmethyl)-4H-pyridine-3,5-dicarboxylic acid diethyl ester is a dihydropyridine.
References
1) Mai et al. (2009), Study of 1,4-dihydropyridine structural scaffold: discovery of novel sirtuin activators and inhibitors; J. Med.Chem.,52 5496