(R)-(+)-Methyl p-tolyl sulfoxide

Product Name: (R)-(+)-Methyl p-tolyl sulfoxide
CAS No.: 1519-39-7
Chemical Name: (R)-(+)-Methyl p-tolyl sulfoxide
Synonyms: (R)-(+)-METHYL P-TOLYL SULFOXIDE;(R)-methyl4-methylphenylsulfoxide;1-Methanesulfinyl-4-methyl-benzene;(R)-(+)-Methyl p-tolyl sulfoxide 99%;(R)-1-Methyl-4-(Methylsulfinyl)benzene;1-methyl-4-[(R)-methylsulfinyl]benzene;Benzene, 1-methyl-4-[(R)-methylsulfinyl]-;(R)-(+)-Methyl p-tolyl sulfoxide
CBNumber: CB3276835
Molecular Formula: C8H10OS
Formula Weight: 154.23
MOL File: 1519-39-7.mol

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(R)-(+)-Methyl p-tolyl sulfoxide Property

Melting point:: 73-75 °C(lit.)
Boiling point:: 247.62°C (rough estimate)
alpha: 145 º (c=2, acetone)
Density: 1.1125 (rough estimate)
refractive index: 1.5780 (estimate)
storage temp.: Storage temp. 2-8°C
form: Solid
Appearance: White to off-white Solid
optical activity: [α]20/D +145°, c = 2 in acetone
BRN: 2040677

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Safety

Safety Statements: 22-24/25
WGK Germany: 3
F: 3-10
HS Code: 2930909899

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 343609
Product name: (R)-(+)-Methyl p-tolyl sulfoxide
Purity: 99%
Packaging: 1g
Price: $380.88
Updated: 2025/07/31

Apolloscientific

Product number: OR913597
Product name: (R)-(+)-Methyl p-tolyl sulfoxide
Purity: 95%
Packaging: 1g
Price: $486
Updated: 2021/12/16

Apolloscientific

Product number: OR913597
Product name: (R)-(+)-Methyl p-tolyl sulfoxide
Purity: 95%
Packaging: 250mg
Price: $182
Updated: 2021/12/16

AK Scientific

Product number: N143
Product name: (R)-(+)-Methyl p-tolyl sulfoxide
Packaging: 250mg
Price: $185
Updated: 2021/12/16

Alichem

Product number: 1519397
Product name: (R)-(+)-Methyl p-tolyl sulfoxide
Packaging: 5g
Price: $567
Updated: 2021/12/16

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(R)-(+)-Methyl p-tolyl sulfoxide Chemical Properties,Usage,Production

Uses

Used in asymmetric synthesis; adds diastereoselectively to carbony compounds, esters, imines, nitrones, and nitrile oxides.

General Description

(R)-(+)-Methyl p-tolyl sulfoxide may be used to prepare (R)-(+)-methyl 3,5-dimethoxy-6-[8-oxo-9-(p-tolylsulfinyl) nonyl] benzoate, an intermediate for (R)-lasiodiplodin synthesis. Its anions undergo addition reaction with nitrones to form optically active a-substituted N-hydroxylamines. (R)-(+)-Methyl p-tolyl sulfoxide also reacts with O-mesitylsulfonylhydroxylamine (MSH) to form (-)-(R)-S-methyl-S-p-tolylsulfoximine.

Synthesis

(R)-(+)-Methyl p-tolyl sulfoxide is prepared by the nucleophilic displacement of (-)- (1R,2S,5R)-Menthyl (S)-p-Toluenesulfinate with methyl Grignard with complete inversion of configuration at sulfur (eq 1).

Synthesis

Highly sensitive to air and moisture. Its generation and handling must be carried out under an inert atmosphere of nitrogen or argon. Normally, preparation is carried out immediately prior to use.

(R)-(+)-Methyl p-tolyl sulfoxide Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(+)-Methyl p-tolyl sulfoxide Suppliers

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1519-39-7, (R)-(+)-Methyl p-tolyl sulfoxideRelated Search:

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(R)-(+)-METHYL P-TOLYL SULFOXIDE

(R)-methyl4-methylphenylsulfoxide

1-Methanesulfinyl-4-methyl-benzene

(R)-1-Methyl-4-(Methylsulfinyl)benzene

(R)-(+)-Methyl p-tolyl sulfoxide 99%

Benzene, 1-methyl-4-[(R)-methylsulfinyl]-

1-methyl-4-[(R)-methylsulfinyl]benzene

(<i>R</i>)-(+)-Methyl <i>p</i>-tolyl sulfoxide

1519-39-7

Chiral Building Blocks

Asymmetric Synthesis

Organic Building Blocks

Sulfoxides

Chiral Compound

Chiral Building Blocks

Organic Building Blocks

Sulfoxides