5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE
- Product Name
- 5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE
- CAS No.
- 824-52-2
- Chemical Name
- 5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE
- Synonyms
- 5-METHYL-7-AZAINDOLE;5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE;1H-Pyrrolo[2,3-b]pyridine, 5-methyl-
- CBNumber
- CB3279018
- Molecular Formula
- C8H8N2
- Formula Weight
- 132.16
- MOL File
- 824-52-2.mol
5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE Property
- Melting point:
- 138-139 °C
- Boiling point:
- 365.4±15.0 °C(Predicted)
- Density
- 1.17±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- form
- solid
- pka
- 7.94±0.20(Predicted)
- Appearance
- White to light yellow Solid
- InChI
- InChI=1S/C8H8N2/c1-6-4-7-2-3-9-8(7)10-5-6/h2-5H,1H3,(H,9,10)
- InChIKey
- DJCJHFFRHKGOCQ-UHFFFAOYSA-N
- SMILES
- C12NC=CC1=CC(C)=CN=2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- ADE000939
- Product name
- 5-Methyl-1H-pyrrolo[2,3-b]pyridine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $817
- Updated
- 2025/07/31
- Product number
- 026236
- Product name
- 5-Methyl-1H-pyrrolo[2,3-b]pyridine
- Packaging
- 50mg
- Price
- $25
- Updated
- 2021/12/16
- Product number
- OR964572
- Product name
- 5-Methyl-1H-pyrrolo[2,3-b]pyridine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 3H32-1-HE
- Product name
- 5-Methyl-1H-pyrrolo[2,3-b]pyridine
- Purity
- 98%
- Packaging
- 250mg
- Price
- $208
- Updated
- 2021/12/16
- Product number
- OR964572
- Product name
- 5-Methyl-1H-pyrrolo[2,3-b]pyridine
- Purity
- 98%
- Packaging
- 1g
- Price
- $295
- Updated
- 2021/12/16
5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE Chemical Properties,Usage,Production
Chemical Properties
5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE is Light yellow solid
Uses
5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE is an intermediate for preparation of pyrrolopyridine compounds as protein kinase modulators useful in treatment of diseases associated with aberrant activity of protein kinases.
Synthesis
500903-95-7
824-52-2
The general procedure for the synthesis of 5-methyl-7-azaindole from 5-methyl-3-((trimethylmethylsilyl)alkynyl)pyridin-2-amine was as follows: 5-methyl-3-((trimethylsilyl)alkynyl)pyridin-2-amine (9.8 g, 48.0 mmol) and N-methylpyrrolidinone (50 mL) were added to a dry three-necked flask. Under ice bath conditions, sodium hydride (60% dispersed in mineral oil, 2.8 g, 59 mmol) was slowly added, followed by heating the reaction mixture to 100 degrees Celsius and holding for 10 minutes. Upon completion of the reaction, the mixture was cooled to room temperature and saturated ammonium chloride solution (50 mL) was slowly added to quench the reaction. Extraction was performed with ethyl acetate (50 mL x 3) and the organic phases were combined. The organic phase was washed sequentially with water (100 mL) and saturated brine (100 mL) and then dried over anhydrous sodium sulfate. After filtration, the filtrate was concentrated to dryness in a rotary evaporator to obtain the crude product. The crude product was recrystallized with ethyl acetate (10 mL) to give 5-methyl-7-azaindole (5.1 g, 38.6 mmol, 80% yield) as a white solid.
References
[1] Patent: CN107056781, 2017, A. Location in patent: Paragraph 0008
[2] Patent: WO2017/133667, 2017, A1. Location in patent: Page/Page column 120
[3] Patent: US2009/253679, 2009, A1. Location in patent: Page/Page column 41
[4] Patent: WO2008/4117, 2008, A1
5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE Preparation Products And Raw materials
Raw materials
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View Lastest Price from 5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE manufacturers
- Product
- 5-METHYL-1H-PYRROLO[2,3-B]PYRIDINE 824-52-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-17