ChemicalBook > CAS DataBase List > Doxycycline monohydrate

Doxycycline monohydrate

Product Name
Doxycycline monohydrate
CAS No.
17086-28-1
Chemical Name
Doxycycline monohydrate
Synonyms
DOXYCYCLINE HYDRATE;Power v1;NSC-56228;Strong v1;Doxycyeline HCL;Doxycycline USP;oxycyclinemonohydrate;DOXYCYCLINE MONOHYDRATE;Doxycycline Monohydrate (100 mg);Doxycycline monohydrate USP/EP/BP
CBNumber
CB3289107
Molecular Formula
C22H26N2O9
Formula Weight
462.45
MOL File
17086-28-1.mol
More
Less

Doxycycline monohydrate Property

Melting point:
167-168℃
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO: soluble1mg/mL
form 
powder or crystals
color 
Light Yellow
Water Solubility 
Soluble in ethanol or methanol. Sparingly soluble in water.Soluble in dilute acids, alkali hydroxides and dimethyl sulfoxide.
CAS DataBase Reference
17086-28-1
More
Less

Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22-63
Safety Statements 
26-36/37
WGK Germany 
3
HS Code 
29413000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D1822
Product name
Doxycycline monohydrate
Packaging
500mg
Price
$76.9
Updated
2024/03/01
Alfa Aesar
Product number
J63805
Product name
Doxycycline monohydrate
Packaging
5g
Price
$43
Updated
2024/03/01
Alfa Aesar
Product number
J63805
Product name
Doxycycline monohydrate
Packaging
25g
Price
$162
Updated
2024/03/01
Usbiological
Product number
D9100
Product name
Doxycycline Monohydrate
Packaging
10g
Price
$79
Updated
2021/12/16
AK Scientific
Product number
J95258
Product name
Doxycycline monohydrate
Packaging
25g
Price
$95
Updated
2021/12/16
More
Less

Doxycycline monohydrate Chemical Properties,Usage,Production

Description

Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a semi-synthetic tetracycline. Doxycycline penetrates the bacterial cell and interferes with the protein biosynthesis, stopping the process. Other microorganisms are also sensitive to the antibiotic activity of Doxycycline, such as Mycoplasma, Chlamydia and Ricketsiae. Resistance to antibiotics of the tetracycline family is primarily due to inhibition of transport of the drug into the cell or by increasing antibiotic efflux. The biological mechanism is mainly through plasmid mediation but it may also occur by chromossomal alteration.

Chemical Properties

Doxycycline monohydrate is a Yellow, crystalline powder. It is soluble in ethanol or methanol. It has a high degree of lipid solubility and a low affinity for calcium binding. It is highly stable in normal human serum. It is very slightly soluble in water.

Uses

Doxycycline Monohydrate is used to treat bacterial infections, Lyme disease, chlamydia, Rocky Mountain Spotted Fever, and other susceptible bacterial infections. It is an antibiotic with bacteriostatic properties.
Tetracycline antibacterial.

Uses

An antimicrobial. Inhibits angiogenesis and reduces lung metastases by inhibiting matrix metalloproteinasesDoxycycline monohydrate acts as an antibiotic, antimicrobial agent and a matrix metalloproteinase inhibitor. It is also used for the treatment of chloroquine-resistant falciparum malaria. Further, it is used to treat a wide variety of bacterial infections, including those that cause acne. In addition to this, it inhibits the bacterial protein synthesis by preventing the interaction of aminoacyl-tRNA and the bacterial ribosome.

Application

In yeast cells, doxycycline has been used in doxycycline-inducible system for overexpression of methyltransferase Hmt1 (hnRNP methyltransferase 1).
It has been used in the doxycycline-inducible IFITM (interferon-induced transmembrane) cell lines.
It has also been used as an antimicrobial agent.

Indications

Doxycycline monohydrate (Vibramycin Monohydrate, Monodox, Mondoxyne NL) is a moderately priced drug used to treat many kinds of infections, like dental, skin, respiratory, and urinary tract infections. It also treats acne, Lyme disease, malaria, and certain sexually transmitted infections. This drug is more popular than comparable drugs. It is available in multiple brand and generic versions. Generic doxycycline monohydrate is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. The lowest GoodRx price for the most common version of doxycycline monohydrate is around $6.02, 80% off the average retail price of $30.66. Compare tetracycline antibiotics.

Definition

ChEBI: The monohydrate form of doxycycline. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary isease (COPD), and adult periodontitis.

brand name

Doxychel (Rachelle); Monodox (Oclassen); Oracea (CollaGenex); Vibramycin (Pfizer).

General Description

Doxycycline was synthesized by Pfizer starting with either tetracycline or oxytetracycline in 1958. It shows about fourfold higher antibacterial activity than tetracycline against a variety of pathogens. Doxycycline shows higher oral absorption than tetracycline, and its concentration in tissue is higher and maintained longer. Hyclate is a preparation of doxycycline containing one mole of hydrochloric acid and one-half mole each of ethanol and water per mole of doxycycline.

Biological Activity

Doxycycline is a semisynthetic tetracycline that is active against bacteria, mycoplasma and protozoan parasites. It inhibits the bacterial protein synthesis by inhibiting the interaction of aminoacyl-tRNA and the bacterial ribosome.

Doxycycline monohydrate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Doxycycline monohydrate Suppliers

Nantong Feiyu Biological Technology CO.,LTD
Tel
0513-68819626; 15152877458
Fax
0513-68669626
Email
feiyubio@163.com
Country
China
ProdList
4819
Advantage
58
Shanghai xiao nai medical technology co., LTD
Tel
15800465632
Fax
QQ:37837302
Email
jiagaolong@126.com
Country
China
ProdList
117
Advantage
58
Guangzhou Xucheng Biotechnology Co., Ltd
Tel
16539527651
Email
2432687429@qq.com
Country
China
ProdList
30
Advantage
58
Anhui heavy sky biological technology Co., LTD
Tel
15556773118 15556773118
Email
ct15556773118@qq.com
Country
China
ProdList
21
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Fax
021-55660885
Email
sales@jonln.com
Country
China
ProdList
1995
Advantage
65
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8844
Advantage
52
More
Less

View Lastest Price from Doxycycline monohydrate manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
Doxycycline monohydrate 17086-28-1
Price
US $10.00-150.00/g
Min. Order
5g
Purity
99%
Supply Ability
50
Release date
2024-07-12
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Doxycycline 17086-28-1
Price
US $4.99/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2021-12-24
Hong Kong Tiansheng New Material Trading Co., Ltd
Product
Doxycycline 17086-28-1
Price
US $16.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10kg
Release date
2022-01-07

17086-28-1, Doxycycline monohydrateRelated Search:


  • DOXYCYCLINE HYDRATE
  • DOXYCYCLINE MONOHYDRATE
  • 4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-2-NA
  • 4-(DIMETHYLAMINO)-1,4,4 ALPHA,5,5 ALPHA,6,11,12 ALPHA-OCTAHYDRO-3,5,10,12,12 ALPHA-PENTAHYDROXY-6-METHYL-1,11-DIOXO-2-NAPHTHACENECARBOXAMIDE, MONOHYDRATE
  • Doxycycline Hycate BP2000/Ph Eur 4/USP25
  • Doxycyeline HCL
  • DoxycyclineHyclate/Monohydrate24390-14-5/Mono
  • 2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione hydrate
  • Strong v1
  • 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrate, (4S,4aR,5S,5aR,6R,12aS)-
  • NSC-56228
  • Doxycycline Monohydrate/Doxycycline base
  • 4-(DiMethylaMino)-3,5,10,12,12a-pentahydroxy-6-Methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxaMide hydrate
  • 4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrote
  • Doxycycline USP
  • Doxycycline Monohydrate (100 mg)
  • Power v1
  • 6-Deoxy-5-oxytetracycline Monohydrate
  • Doxycycline monohydrate USP/EP/BP
  • Doxycycline monohydrateQ: What is Doxycycline monohydrate Q: What is the CAS Number of Doxycycline monohydrate Q: What is the storage condition of Doxycycline monohydrate Q: What are the applications of Doxycycline monohydrate
  • oxycyclinemonohydrate
  • (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrate
  • 17086-28-1
  • 17080-28-1
  • C22H24N2O8xH2O
  • NONE
  • Other
  • PERIOSTAT
  • Drug bulk