Doxycycline monohydrate

Product Name: Doxycycline monohydrate
CAS No.: 17086-28-1
Chemical Name: Doxycycline monohydrate
Synonyms: DOXYCYCLINE HYDRATE;Power v1;NSC-56228;Strong v1;Doxycyeline　HCL;Doxycycline USP;oxycyclinemonohydrate;DOXYCYCLINE MONOHYDRATE;Doxycycline Monohydrate (100 mg);Doxycycline monohydrate USP/EP/BP
CBNumber: CB3289107
Molecular Formula: C22H26N2O9
Formula Weight: 462.45
MOL File: 17086-28-1.mol

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Doxycycline monohydrate Property

Melting point:: 167-168℃
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: DMSO: soluble1mg/mL
form: powder or crystals
color: Light Yellow
Water Solubility: Soluble in ethanol or methanol. Sparingly soluble in water.Soluble in dilute acids, alkali hydroxides and dimethyl sulfoxide.
CAS DataBase Reference: 17086-28-1

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22-63
Safety Statements: 26-36/37
WGK Germany: 3
HS Code: 29413000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D1822
Product name: Doxycycline monohydrate
Packaging: 500mg
Price: $76.9
Updated: 2024/03/01

Alfa Aesar

Product number: J63805
Product name: Doxycycline monohydrate
Packaging: 5g
Price: $43
Updated: 2024/03/01

Alfa Aesar

Product number: J63805
Product name: Doxycycline monohydrate
Packaging: 25g
Price: $162
Updated: 2024/03/01

Usbiological

Product number: D9100
Product name: Doxycycline Monohydrate
Packaging: 10g
Price: $79
Updated: 2021/12/16

AK Scientific

Product number: J95258
Product name: Doxycycline monohydrate
Packaging: 25g
Price: $95
Updated: 2021/12/16

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Doxycycline monohydrate Chemical Properties,Usage,Production

Description

Doxycycline is a broad-spectrum antibiotic synthetically derived from oxytetracycline. It is a semi-synthetic tetracycline. Doxycycline penetrates the bacterial cell and interferes with the protein biosynthesis, stopping the process. Other microorganisms are also sensitive to the antibiotic activity of Doxycycline, such as Mycoplasma, Chlamydia and Ricketsiae. Resistance to antibiotics of the tetracycline family is primarily due to inhibition of transport of the drug into the cell or by increasing antibiotic efflux. The biological mechanism is mainly through plasmid mediation but it may also occur by chromossomal alteration.

Chemical Properties

Doxycycline monohydrate is a Yellow, crystalline powder. It is soluble in ethanol or methanol. It has a high degree of lipid solubility and a low affinity for calcium binding. It is highly stable in normal human serum. It is very slightly soluble in water.

Uses

Doxycycline Monohydrate is used to treat bacterial infections, Lyme disease, chlamydia, Rocky Mountain Spotted Fever, and other susceptible bacterial infections. It is an antibiotic with bacteriostatic properties.
Tetracycline antibacterial.

Uses

An antimicrobial. Inhibits angiogenesis and reduces lung metastases by inhibiting matrix metalloproteinasesDoxycycline monohydrate acts as an antibiotic, antimicrobial agent and a matrix metalloproteinase inhibitor. It is also used for the treatment of chloroquine-resistant falciparum malaria. Further, it is used to treat a wide variety of bacterial infections, including those that cause acne. In addition to this, it inhibits the bacterial protein synthesis by preventing the interaction of aminoacyl-tRNA and the bacterial ribosome.

Application

In yeast cells, doxycycline has been used in doxycycline-inducible system for overexpression of methyltransferase Hmt1 (hnRNP methyltransferase 1).
It has been used in the doxycycline-inducible IFITM (interferon-induced transmembrane) cell lines.
It has also been used as an antimicrobial agent.

Indications

Doxycycline monohydrate (Vibramycin Monohydrate, Monodox, Mondoxyne NL) is a moderately priced drug used to treat many kinds of infections, like dental, skin, respiratory, and urinary tract infections. It also treats acne, Lyme disease, malaria, and certain sexually transmitted infections. This drug is more popular than comparable drugs. It is available in multiple brand and generic versions. Generic doxycycline monohydrate is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. The lowest GoodRx price for the most common version of doxycycline monohydrate is around $6.02, 80% off the average retail price of $30.66. Compare tetracycline antibiotics.

Definition

ChEBI: The monohydrate form of doxycycline. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary isease (COPD), and adult periodontitis.

brand name

Doxychel (Rachelle); Monodox (Oclassen); Oracea (CollaGenex); Vibramycin (Pfizer).

General Description

Doxycycline was synthesized by Pfizer starting with either tetracycline or oxytetracycline in 1958. It shows about fourfold higher antibacterial activity than tetracycline against a variety of pathogens. Doxycycline shows higher oral absorption than tetracycline, and its concentration in tissue is higher and maintained longer. Hyclate is a preparation of doxycycline containing one mole of hydrochloric acid and one-half mole each of ethanol and water per mole of doxycycline.

Biological Activity

Doxycycline is a semisynthetic tetracycline that is active against bacteria, mycoplasma and protozoan parasites. It inhibits the bacterial protein synthesis by inhibiting the interaction of aminoacyl-tRNA and the bacterial ribosome.

Doxycycline monohydrate Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Doxycycline hydrochloride

Preparation Products

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Doxycycline monohydrate Suppliers

China 184 Europe 3 Germany 2 India 7 Portugal 1 South Korea 1 United Kingdom 7 United States 23 Global 228

Pure Chemistry Scientific Inc.

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Aladdin Scientific

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View Lastest Price from Doxycycline monohydrate manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Doxycycline monohydrate 17086-28-1
Price: US $10.00-150.00/g
Min. Order: 5g
Purity: 99%
Supply Ability: 50
Release date: 2024-07-12

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Doxycycline 17086-28-1
Price: US $4.99/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2021-12-24

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: Doxycycline 17086-28-1
Price: US $16.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10kg
Release date: 2022-01-07

17086-28-1, Doxycycline monohydrateRelated Search:

METHACYCLINE Doxycycline monohydrate BP2000/Ph Eur 4/USP25 MELIBIOSE 3-Dimethylaminopropylamine 4-Dimethylaminobenzaldehyde 4-Dimethylaminopyridine Doxycycline Doxycycline Hyclate IMpurity F Doxycycline Impurity 7(N-Desmethyl Doxycycline) DOXYCYCLINE SSA 6-Deoxy-4-epioxytetracycline epi-Doxycycline Oxytetracycline 4-Epi-6-epi Doxycycline Doxycycline Hydrate 2-Dimethylaminoethanol NAPHTHACENE DOXYCYCLINE MONOHYDRATE

DOXYCYCLINE HYDRATE

DOXYCYCLINE MONOHYDRATE

4-(DIMETHYLAMINO)-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,5,10,12,12A-PENTAHYDROXY-6-METHYL-1,11-DIOXO-2-NA

4-(DIMETHYLAMINO)-1,4,4 ALPHA,5,5 ALPHA,6,11,12 ALPHA-OCTAHYDRO-3,5,10,12,12 ALPHA-PENTAHYDROXY-6-METHYL-1,11-DIOXO-2-NAPHTHACENECARBOXAMIDE, MONOHYDRATE

Doxycycline Hycate BP2000/Ph Eur 4/USP25

Doxycyeline　HCL

DoxycyclineHyclate/Monohydrate24390-14-5/Mono

2-[amino(hydroxy)methylidene]-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methyl-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione hydrate

Strong v1

2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, monohydrate, (4S,4aR,5S,5aR,6R,12aS)-

NSC-56228

Doxycycline Monohydrate/Doxycycline base

4-(DiMethylaMino)-3,5,10,12,12a-pentahydroxy-6-Methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxaMide hydrate

4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrote

Doxycycline USP

Doxycycline Monohydrate (100 mg)

Power v1

6-Deoxy-5-oxytetracycline Monohydrate

Doxycycline monohydrate USP/EP/BP

Doxycycline monohydrateQ: What is Doxycycline monohydrate Q: What is the CAS Number of Doxycycline monohydrate Q: What is the storage condition of Doxycycline monohydrate Q: What are the applications of Doxycycline monohydrate

oxycyclinemonohydrate

(4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide hydrate

17086-28-1

17080-28-1

C22H24N2O8xH2O

NONE

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PERIOSTAT

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