4-Aminothiophenol Property

Melting point:

37-42 °C(lit.)

Boiling point:

140-145 °C16 mm Hg(lit.)

Density 

1.136 (estimate)

refractive index 

1.4606 (estimate)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

7.3g/l

pka

8.74±0.10(Predicted)

form 

Crystals, Flakes or Crystalline Mass

color 

Off-white to brown

Water Solubility 

Immiscible with water.

Sensitive 

Stench

BRN 

906904

CAS DataBase Reference

1193-02-8(CAS DataBase Reference)

NIST Chemistry Reference

4-Aminothiophenol(1193-02-8)

EPA Substance Registry System

4-Aminothiophenol (1193-02-8)

Safety

Hazard Codes 

C

Risk Statements 

34-37

Safety Statements 

26-28-36/37/39-45-25-27

RIDADR 

UN 3263 8/PG 2

WGK Germany 

3

RTECS 

DC0602500

F 

10-13-23

Hazard Note 

Corrosive/Stench

HazardClass 

8

PackingGroup 

III

HS Code 

29309070

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

4-Aminothiophenol Chemical Properties,Usage,Production

Chemical Properties

yellow crystalline low melting mass

Uses

4-Aminothiophenol is used in the synthesis of pectin-4-aminothiophenol conjugates and it forms self-assembled monolayers (SAMs) in the development of DNA. It is used in the detection of thrombin by protein recognition using surface-enhanced Raman spectroscopy (SERS), which finds applications in silver and gold nano particles. It acts as a linker to thiol (SH) functionalizes multiwalled carbon nanotubes (MWCNTs).

Uses

4-Aminothiophenol (4-ATP) was employed as bifunctional molecule to functionalize gold nanoparticles (NPs) used in surface-enhanced Raman spectroscopy (SERS) detection of thrombin by protein recognition.

Preparation

synthesis of 4-aminothiophenol: A mixture of 128 g. of p-chloronitrobenzene and a solution of 480 g. of sodium sulfide nonahydrate in 2 l. of water is heated to reflux for 8 hours. The cooled mixture is extracted with ether to remove a small amount of oil, the remaining aqueous solution is saturated with sodium chloride, and 240 g. of glacial acetic acid is added. The precipitated oil is removed by ether extraction, and the resulting ethereal solution is dried over sodium sulfate and distilled to give 70 g. (69%) of 4-aminothiophenol boiling at 143-146°/17 mm. and melting at 43-45°.

General Description

4-Aminothiophenol (p-aminothiophenol, PATP) is an aromatic thiol. The self-assembly of silver and gold nano particles which are interconnected with 4-ATP to form metal-molecule-metal sandwich architecture has been characterized by surface enhanced Raman scattering (SERS) using an off-surface plasmon resonance condition. Chemical transformation of PATP to 4,4-dimercaptoazobenzene (DMAB) has been extensively studied.