1,2,3-1H-Triazole
Description- Product Name
- 1,2,3-1H-Triazole
- CAS No.
- 288-36-8
- Chemical Name
- 1,2,3-1H-Triazole
- Synonyms
- 1,2,3-TRIAZOLE;1H-1,2,3-TRIAZOLE;2H-1,2,3-Triazole;Osotriazole;2H-Triazole;1h-1,2,3-Trizole;Triazacyclopentadiene;V-triazole;3-Triazole;vic-triazole
- CBNumber
- CB3290804
- Molecular Formula
- C2H3N3
- Formula Weight
- 69.07
- MOL File
- 288-36-8.mol
1,2,3-1H-Triazole Property
- Melting point:
- 23-25 °C(lit.)
- Boiling point:
- 203 °C752 mm Hg(lit.)
- Density
- 1.192 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.498(lit.)
- Flash point:
- 225 °F
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Acetone, Chloroform, Methanol (Slightly)
- form
- Liquid
- pka
- 1.17(at 20℃)
- color
- Clear colorless to yellow
- Specific Gravity
- 1.192
- Water Solubility
- soluble
- FreezingPoint
- 21.0 to 24.0 ℃
- BRN
- 104766
- InChIKey
- QWENRTYMTSOGBR-UHFFFAOYSA-N
- CAS DataBase Reference
- 288-36-8(CAS DataBase Reference)
- NIST Chemistry Reference
- 1H-1,2,3-Triazole(288-36-8)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-63-36-22
- Safety Statements
- 37/39-26-36/37
- WGK Germany
- 3
- Hazard Note
- Irritant
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 333662
- Product name
- 1H-1,2,3-Triazole
- Purity
- 97%
- Packaging
- 1g
- Price
- $56.5
- Updated
- 2025/07/31
- Product number
- 333662
- Product name
- 1H-1,2,3-Triazole
- Purity
- 97%
- Packaging
- 5g
- Price
- $154
- Updated
- 2025/07/31
- Product number
- T1880
- Product name
- 1H-1,2,3-Triazole
- Purity
- >98.0%(T)
- Packaging
- 5g
- Price
- $115
- Updated
- 2025/07/31
- Product number
- T1880
- Product name
- 1H-1,2,3-Triazole
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $403
- Updated
- 2025/07/31
- Product number
- T767390
- Product name
- 1H-1,2,3-Triazole
- Packaging
- 100g
- Price
- $1205
- Updated
- 2021/12/16
1,2,3-1H-Triazole Chemical Properties,Usage,Production
Description
1,2,3-1H-Triazole is a kind of azole compound. It can effectively promote the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism. It is also a useful triazole for proteomics research1. It also find use in research as a bioisostere in medicinal chemistry as well as an building block for more complex chemical compounds, including pharmaceutical drugs such as mubritinib and tazobactam2. It is a main class of hetero-cycles because of its extensive range of biological properties such as antimicrobial, anticancer, anti-tubercular, anti-HIV, antimalarial, antibacterial, antifungal, antiviral and anti-diabetic property3.
Chemical Properties
clear colorless liquid
Uses
A basic 5-membered aromatic heterocycle used as a building block for more complex pharmaceutical compounds. There have been recent studies that showed antitumor, antiinflammatory, analgesic, antifunga l, antibacterial and antiviral activities in bioactive triazoles.
Uses
It effectively promotes the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism. A useful triazole for proteomics research
Definition
ChEBI: 1H-1,2,3-triazole is a 1,2,3-triazole. It is a tautomer of a 2H-1,2,3-triazole and a 4H-1,2,3-triazole.
Synthesis Reference(s)
The Journal of Organic Chemistry, 62, p. 9177, 1997 DOI: 10.1021/jo971313o
General Description
2H-1,2,3-triazole is tautomeric form of 1H-1,2,3-triazole. 1H-1,2,3-triazole effectively promotes the proton conduction in polymer electrolyte membranes via an intermolecular proton-transfer mechanism.
Synthesis
4546-95-6
288-36-8
General procedure for the synthesis of 1,2,3-triazole from 1H-1,2,3-triazole-4,5-dicarboxylic acid: to a 2000 mL four-neck flask was added 1250 mL of pure water and 157.08 g (1.0 mol) of 1H-1,2,3-triazole-4,5-dicarboxylic acid, followed by the addition of 4.71 g (equivalent to 1H-1,2,3-triazole-4,5-dicarboxylic acid 3% by mass) of N,N-diisopropylethylamine. The reaction mixture was heated to 100~110°C under atmospheric pressure and refluxed until the reaction solution was clarified. Refluxing was continued for 1 h. The reaction was monitored by HPLC and terminated when the residue of 1H-1,2,3-triazole-4,5-dicarboxylic acid was less than 1%. After completion of the reaction, filtration was performed. A vacuum pump was used to remove most of the water from the filtrate, which was then replaced with a mechanical pump for high vacuum dehydration. The four-necked flask was mounted on a distillation apparatus and vacuum distillation was carried out, resulting in 66.48 g of 1H-1,2,3-triazole with a molar yield of 96.25% and a GC purity of 99.56%.
References
[1] Patent: CN106946803, 2017, A. Location in patent: Paragraph 0035; 0040; 0041; 0045; 0046; 0050; 0051
[2] Patent: CN105330607, 2016, A. Location in patent: Paragraph 0033; 0034
[3] Chemische Berichte, 1893, vol. 26, p. 2737
1,2,3-1H-Triazole Preparation Products And Raw materials
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View Lastest Price from 1,2,3-1H-Triazole manufacturers
- Product
- 1,2,3-1H-Triazole 288-36-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-25
- Product
- 1,2,3-1H-Triazole 288-36-8
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg/week
- Release date
- 2024-05-20
- Product
- 1,2,3-1H-Triazole 288-36-8
- Price
- US $100.00-50.00/kgkg
- Min. Order
- 1kgkg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2023-09-28