Azido-PEG1-PFP ester
- Product Name
- Azido-PEG1-PFP ester
- CAS No.
- 1807505-32-3
- Chemical Name
- Azido-PEG1-PFP ester
- Synonyms
- Azido-PEG1-PFP ester;N3-PEG1-CH2CH2COOPFP;perfluorophenyl 3-(2-azidoethoxy)propanoate;Pentafluorophenyl 3-(2-azidoethoxy)propanoate;(2,3,4,5,6-pentafluorophenyl) 3-(2-azidoethoxy)propanoate;2,3,4,5,6-pentafluorophenyl-3-(2-azaethoxy)propanoic acidester;Perfluorophenyl 3-(2-azidoethoxy)propanoate , Azido-PEG1-PFP ester
- CBNumber
- CB33062341
- Molecular Formula
- C11H8F5N3O3
- Formula Weight
- 325.2
- MOL File
- 1807505-32-3.mol
Azido-PEG1-PFP ester Property
- solubility
- Soluble in DMSO, DCM, DMF
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BP-21861
- Product name
- Azido-PEG1-PFPester
- Purity
- 98%
- Packaging
- 100mg
- Price
- $260
- Updated
- 2021/12/16
- Product number
- BP-21861
- Product name
- Azido-PEG1-PFPester
- Purity
- 98%
- Packaging
- 250mg
- Price
- $460
- Updated
- 2021/12/16
- Product number
- BP-21861
- Product name
- Azido-PEG1-PFPester
- Purity
- 98%
- Packaging
- 1g
- Price
- $950
- Updated
- 2021/12/16
Azido-PEG1-PFP ester Chemical Properties,Usage,Production
Description
Azido-PEG1-PFP ester is a click chemistry PEG linker containing azide and PFP ester moities. The azide can participate in copper-catalyzed Click Chemistry reactions with alkynes, DBCO and BCN to form triazole groups. The PFP ester is amine-reactive and is less susceptible toward hydrolysis compared to NHS ester.
Uses
Azido-PEG1-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-PFP ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Azido-PEG1-PFP ester Preparation Products And Raw materials
Raw materials
Preparation Products
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