ChemicalBook > CAS DataBase List > UNC2170 Maleate
UNC2170 Maleate
- Product Name
- UNC2170 Maleate
- CAS No.
- 1648707-58-7
- Chemical Name
- UNC2170 Maleate
- Synonyms
- UNC-2170;UNC-2170 HCl;UNC2170 Maleate;UNC2170 trifluoroacetate;3-Bromo-N-(3-(tert-butylamino)propyl)benzamide;Benzamide, 3-bromo-N-[3-[(1,1-dimethylethyl)amino]propyl]-;UNC-2170,UNC2170,Kme readers,tudor domain,UNC 2170,H4K20me2,ligand,53BP1,inhibit,double-strand DNA breaks,Inhibitor
- CBNumber
- CB33067588
- Molecular Formula
- C14H21BrN2O
- Formula Weight
- 313.23
- MOL File
- 1648707-58-7.mol
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UNC2170 Maleate Property
- Boiling point:
- 419.6±30.0 °C(Predicted)
- Density
- 1.233±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 40 mg/ml) or in Water (up to 50 mg/ml).
- form
- solid
- pka
- 14.63±0.46(Predicted)
- color
- White
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 17374
- Product name
- UNC2170 (maleate)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $42
- Updated
- 2022/04/27
Cayman Chemical
- Product number
- 17374
- Product name
- UNC2170 (maleate)
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $165
- Updated
- 2022/04/27
Cayman Chemical
- Product number
- 17374
- Product name
- UNC2170 (maleate)
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $309
- Updated
- 2022/04/27
Cayman Chemical
- Product number
- 17374
- Product name
- UNC2170 (maleate)
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $668
- Updated
- 2022/04/27
AK Scientific
- Product number
- SYN5678
- Product name
- UNC2170maleate
- Packaging
- 50mg
- Price
- $1052
- Updated
- 2021/12/16
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UNC2170 Maleate Chemical Properties,Usage,Production
Description
UNC-2170 (1648707-58-7), identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170 functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1
References
1) Perfetti?et al.?(2015),?Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein 53BP1; ACS Chem. Biol.,?10?1072
UNC2170 Maleate Preparation Products And Raw materials
Raw materials
Preparation Products
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UNC2170 Maleate Suppliers
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- +86-400-851-9921
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- +86-10-82826195
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- China
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- 44-20819178-90 02081917890
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- (0)2080432064
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- Country
- China
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