UNC2170 Maleate

Product Name: UNC2170 Maleate
CAS No.: 1648707-58-7
Chemical Name: UNC2170 Maleate
Synonyms: UNC-2170;UNC-2170 HCl;UNC2170 Maleate;UNC-2170, 10 mM in DMSO;UNC2170 trifluoroacetate;3-Bromo-N-(3-(tert-butylamino)propyl)benzamide;Benzamide, 3-bromo-N-[3-[(1,1-dimethylethyl)amino]propyl]-;UNC-2170,UNC2170,Kme readers,tudor domain,UNC 2170,H4K20me2,ligand,53BP1,inhibit,double-strand DNA breaks,Inhibitor
CBNumber: CB33067588
Molecular Formula: C14H21BrN2O
Formula Weight: 313.23
MOL File: 1648707-58-7.mol

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UNC2170 Maleate Property

Boiling point:: 419.6±30.0 °C(Predicted)
Density: 1.233±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 40 mg/ml) or in Water (up to 50 mg/ml).
pka: 14.63±0.46(Predicted)
form: solid
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
InChI: 1S/C14H21BrN2O.C2HF3O2/c1-14(2,3)17-9-5-8-16-13(18)11-6-4-7-12(15)10-11;3-2(4,5)1(6)7/h4,6-7,10,17H,5,8-9H2,1-3H3,(H,16,18);(H,6,7)
InChIKey: DPAGQICQYYQSQP-UHFFFAOYSA-N
SMILES: BrC1=CC=CC(C(NCCCNC(C)(C)C)=O)=C1.FC(F)(C(O)=O)F

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Safety

WGK Germany: WGK 3
Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications: Acute Tox. 3 Oral

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1434
Product name: UNC2170 trifluoroacetate
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $132.05
Updated: 2025/07/31

Cayman Chemical

Product number: 17374
Product name: UNC2170 (maleate)
Purity: ≥95%
Packaging: 1mg
Price: $42
Updated: 2022/04/27

Cayman Chemical

Product number: 17374
Product name: UNC2170 (maleate)
Purity: ≥95%
Packaging: 5mg
Price: $165
Updated: 2022/04/27

Cayman Chemical

Product number: 17374
Product name: UNC2170 (maleate)
Purity: ≥95%
Packaging: 10mg
Price: $309
Updated: 2022/04/27

Cayman Chemical

Product number: 17374
Product name: UNC2170 (maleate)
Purity: ≥95%
Packaging: 25mg
Price: $668
Updated: 2022/04/27

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UNC2170 Maleate Chemical Properties,Usage,Production

Description

UNC-2170 (1648707-58-7), identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170 functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1

Uses

UNC-2170 is a functionally active, fragment-like ligand for 53BP1 (IC50=29 μM; Kd=22 μM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB)[1].

References

[1] MICHAEL T. PERFETTI. Identification of a Fragment-like Small Molecule Ligand for the Methyl-lysine Binding Protein, 53BP1[J]. ACS Chemical Biology, 2015, 10 4: 1072-1081. DOI:10.1021/cb500956g

UNC2170 Maleate Preparation Products And Raw materials

Raw materials

Preparation Products

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UNC2170 Maleate Suppliers

China 46 United Kingdom 1 United States 3 Global 50

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
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MQ (shanghai) Pharmaceuticals Co., Ltd.

Tel: 13761635123
Fax: 1014988033@qq
Email: sales@linyuepharm.com
Country: China
ProdList: 5562
Advantage: 55

Dezhou LonWel Pharmaceutical Technology Co., Ltd.

Tel: 13761310616
Fax: QQ: 39324283
Email: 39324283@qq.com
Country: China
ProdList: 1375
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Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
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Country: United Kingdom
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Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
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TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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Country: CHINA
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
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Country: China
ProdList: 11218
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UNC2170 trifluoroacetate

UNC2170 Maleate

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3-Bromo-N-(3-(tert-butylamino)propyl)benzamide

UNC-2170 HCl

UNC-2170,UNC2170,Kme readers,tudor domain,UNC 2170,H4K20me2,ligand,53BP1,inhibit,double-strand DNA breaks,Inhibitor

UNC-2170, 10 mM in DMSO

1648707-58-7