ChemicalBook > CAS DataBase List > 4,4’-Difluoro-2,2’-bipyridine

4,4’-Difluoro-2,2’-bipyridine

Product Name
4,4’-Difluoro-2,2’-bipyridine
CAS No.
1189458-67-0
Chemical Name
4,4’-Difluoro-2,2’-bipyridine
Synonyms
4,4’-Difluoro-2,2’-bipyridine;2,2'-Bipyridine, 4,4'-difluoro-
CBNumber
CB33117128
Molecular Formula
C10H6F2N2
Formula Weight
192.16
MOL File
1189458-67-0.mol
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4,4’-Difluoro-2,2’-bipyridine Property

Boiling point:
287.4±35.0 °C(Predicted)
Density 
1.284±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
2.86±0.30(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
HCH0361186
Product name
4,4'-DIFLUORO-2,2'-BIPYRIDINE
Purity
95.00%
Packaging
5MG
Price
$501.25
Updated
2021/12/16
Ambeed
Product number
A394119
Product name
4,4'-Difluoro-2,2'-bipyridine
Purity
97%
Packaging
1g
Price
$698
Updated
2021/12/16
Chemenu
Product number
CM248064
Product name
4,4''-Difluoro-2,2''-bipyridine
Purity
97%
Packaging
1g
Price
$711
Updated
2021/12/16
Alichem
Product number
1189458670
Product name
4,4'-Difluoro-2,2'-bipyridine
Packaging
1g
Price
$752.4
Updated
2021/12/16
Ambeed
Product number
A394119
Product name
4,4'-Difluoro-2,2'-bipyridine
Purity
97%
Packaging
50mg
Price
$65
Updated
2021/12/16
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4,4’-Difluoro-2,2’-bipyridine Chemical Properties,Usage,Production

Synthesis

18511-69-8

1189458-67-0

The general procedure for the synthesis of 4,4'-diamino-2,2'-bipyridine from 4,4'-diamino-2,2'-bipyridine was as follows: in a polyethylene reaction vessel, 4,4'-diamino-2,2'-bipyridine (2.00 g, 10.7 mmol), hydrogen fluoride-pyridine complex (65% HF, 31.5 g, 1.02 mol) and toluene ( 30mL). After cooling the mixture to -4°C, sodium nitrite (1.85 g, 26.8 mmol, 2.5 equiv) was added to the reaction vessel. The mouth of the reaction vessel was sealed with polyethylene film and the mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the pyridine layer was separated by pipette and subsequently alkalized with aqueous sodium hydroxide to pH=10. The alkalized mixture was filtered and the filtrate was extracted with ethyl acetate. The organic layers were combined and dried over anhydrous sodium sulfate. After evaporation of the solvent, the residue was sublimated in vacuo to afford the target product 4,4'-difluoro-2,2'-bipyridine (0.752 g, 36% yield). Product characterization: colorless needle-like crystals. 1H NMR (300MHz, CDCl3) δ 8.64 (dd, J=8.4Hz, 5.4Hz, 2H), 8.18 (dd, J=9.9Hz, 2.4Hz, 2H), 7.08 (dd, J=7.8Hz, 5.4Hz, 2.4Hz, 2H). 19F NMR (283MHz , CDCl3) δ -111.68 to -111.59 (m).

References

[1] Tetrahedron Letters, 2016, vol. 57, # 49, p. 5489 - 5492

4,4’-Difluoro-2,2’-bipyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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4,4’-Difluoro-2,2’-bipyridine Suppliers

China 31 India 1 United States 2 Global 34
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
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product02@bidepharm.com
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China
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39966
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Nanijing m&m biotechnology Co. ,Ltd.
Tel
025-87782433 18021532344
Fax
025-87782433
Email
1345332203@qq.com
Country
China
ProdList
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9ding chemical ( Shanghai) Limited
Tel
021-021-52271985 17721149837
Fax
+86 (21) 52271987
Email
sales@9dingchem.com
Country
China
ProdList
19800
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60
Sichuan BaiPeng Biotechnology Co., Ltd.
Tel
028-65791793 18140026355
Fax
QQ568470422
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Country
China
ProdList
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Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-85201366 18938635012
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sales@regentsciences.com
Country
China
ProdList
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Shanghai Anyinuo Biomedical Technology Co., Ltd.
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Henan's chemical products co., LTD
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Zhengzhou Acme Chemical Co., Ltd.
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
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Changzhou Carman Chemical Co., ltd
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1189458-67-0, 4,4’-Difluoro-2,2’-bipyridineRelated Search:


  • 4,4’-Difluoro-2,2’-bipyridine
  • 2,2'-Bipyridine, 4,4'-difluoro-
  • 1189458-67-0