ChemicalBook > CAS DataBase List > 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE

2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE

Product Name
2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE
CAS No.
5381-99-7
Chemical Name
2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE
Synonyms
2-Chloro-4H-benzo[d][1,3,2]dioxaphosphinin-4-one;Salicyl Phosphorochloridite;2-CHLORO-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE;2-CHLORO-4H-1,2,3-BENZODIOXAPHOSPHORIN-4-ONE;SALICYLCHLOROPHOSPHITE;SalPCl;NSC 40209;VAN BOOM'S REAGENT;ChloroHbenzodioxaphosphorinone;Salicylchlorophosphite Van Boom's Reagent
CBNumber
CB3312737
Molecular Formula
C7H4ClO3P
Formula Weight
202.53
MOL File
5381-99-7.mol
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2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE Property

Melting point:
36-40 °C (lit.)
Boiling point:
127-128 °C/11 mmHg (lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
Soluble in acetonitrile, dichloromethane, tetrahydrofuron and dimethylformamide.
form 
solid
color 
White or Colorless to Orange to Green
BRN 
1311951
Stability:
Water Sensitive
InChI
InChI=1S/C7H4ClO3P/c8-12-10-6-4-2-1-3-5(6)7(9)11-12/h1-4H
InChIKey
BVOITXUNGDUXRW-UHFFFAOYSA-N
SMILES
O1C2=CC=CC=C2C(=O)OP1Cl
CAS DataBase Reference
5381-99-7(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
14-34-37
Safety Statements 
26-36/37/39-43-45
RIDADR 
UN 3261 8/PG 1
WGK Germany 
3
F 
3-10
Hazard Note 
Corrosive
HazardClass 
8
PackingGroup 
II
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
324124
Product name
2-Chloro-1,3,2-benzodioxaphosphorin-4-one
Purity
95%
Packaging
5g
Price
$131
Updated
2025/07/31
Sigma-Aldrich
Product number
324124
Product name
2-Chloro-1,3,2-benzodioxaphosphorin-4-one
Purity
95%
Packaging
25g
Price
$354
Updated
2025/07/31
TCI Chemical
Product number
C1210
Product name
2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one
Purity
>95.0%(T)
Packaging
5g
Price
$59
Updated
2025/07/31
TCI Chemical
Product number
C1210
Product name
2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one
Purity
>95.0%(T)
Packaging
25g
Price
$178
Updated
2025/07/31
TRC
Product number
C365000
Product name
2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one(90%)
Packaging
25g
Price
$240
Updated
2021/12/16
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2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one is a reagent used in phosphorylation and phosphitylation of alcohols and in the formation of H-phosphonates. It is also reactive cyclic phosphitylating reagent involved in fast coupling rates and hydrolytic cleavage more readily compare to that of a acyclic analog.

Uses

2-Chloro-1,3,2-benzodioxaphosphorin-4-one is used as a reagent:

  • In the phosphorylation and phosphitylation of alcohols.
  • In the formation of H-phosphonates which are commonly utilized in the synthesis of nucleotides.
  • To synthesize nucleoside triphosphates by treating with acyl protected nucleoside.

Uses

Highly reactive cyclic phosphitylating reagent which provides fast coupling rates, and hydrolytic cleavage occurs more readily than with acyclic analogs

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling
reagent type: ligand

2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE Suppliers

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View Lastest Price from 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one 5381-99-7
Price
US $1.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2020-01-16

5381-99-7, 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONERelated Search:

NAD+ 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one 2-oxide DIMETHYLCHLOROPHOSPHITE 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE

  • VAN BOOM'S REAGENT
  • SALICYLCHLOROPHOSPHITE
  • 2-CHLORO-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE
  • 2-CHLORO-4H-1,2,3-BENZODIOXAPHOSPHORIN-4-ONE
  • 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE
  • 2-chloro-1,3,2-benzodioxaphosphonic heterocyclohexane-4-one
  • ChloroHbenzodioxaphosphorinone
  • 2-Chloro-4H-1,2,3-benzodioxaphosphorin-4-one 90%
  • 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE 97%
  • NSC 40209
  • Salicyl Phosphorochloridite
  • Salicylchlorophosphite Van Boom's Reagent
  • 2-Chloro-4H-benzo[d][1,3,2]dioxaphosphinin-4-one
  • 2-Chloro-4H-1,3,2-benzodioxaphosphinin-4-one
  • 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one, Salicyl chlorophosphite
  • SalPCl
  • 2-Chloro-1,3,2-benzodioxaphosphorin-4-one 95%
  • 2-Chloro-4<i>H</i>-1,3,2-benzodioxaphosphorin-4-one
  • 2-chloro-1,3,2-benzodioxaphosphinin-4-one
  • 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one,97%
  • 4H-1,3,2-Benzodioxaphosphorin-4-one,2-chloro-
  • 2-Chloro-4H-1,3,2-benzodioxaphosphinin-4-one 95%
  • 2-chloro-2,4-dihydro-1,3,2-benzodioxaphosphinin-4-one
  • 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one &gt
  • 2-Chloro-4H-1,3,2-benzodioxaphosphorin-4-one (90%)
  • "2-Chloro-4H-1,2,3-benzodioxaphosphorin-4-one 90%"
  • 5381-99-7 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE C7H4ClO3P
  • 5381-99-7
  • C7H4ClO3P
  • Phosphorylating Agents
  • Phosphorylation
  • DNA / RNA Synthesis
  • Catalysis and Inorganic Chemistry
  • Phosphorus Compounds
  • Phosphorus Precursors
  • Phospholipids - 13C & 2H
  • Biochemistry
  • Nucleosides, Nucleotides & Related Reagents
  • Phosphorylating and Phosphorothioating Agents
  • Phosphorylation
  • Protecting Agents, Phosphorylating Agents & Condensing Agents
  • Synthetic Organic Chemistry
  • Phosphorylating and Phosphitylating Agents