ChemicalBook > CAS DataBase List > 3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide

3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide

Product Name
3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide
CAS No.
1874276-76-2
Chemical Name
3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide
Synonyms
IDE-196;LXS-196;EOS-61826;NVP-LXS196;Darovasertib;LXS196,IDE196;LXS-196 (NVP-LXS196);Darovasertib (LXS-196);Darovasertib, 10 mM in DMSO;NVP-LXS196; NVPLXS196; NVP LXS196; LXS-196; LXS 196; LXS196; LXS-196
CBNumber
CB33142692
Molecular Formula
C22H23F3N8O
Formula Weight
472.47
MOL File
1874276-76-2.mol
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3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide Property

Boiling point:
592.7±50.0 °C(Predicted)
Density 
1.387±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 1 mg/ml; DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
form 
A crystalline solid
pka
7.65±0.70(Predicted)
color 
Light yellow to yellow
InChIKey
XXJXHXJWQSCNPX-UHFFFAOYSA-N
SMILES
C1(C(NC2=NC=CC=C2N2CCC(N)(C)CC2)=O)=NC(C2=NC=CC=C2C(F)(F)F)=CN=C1N
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-7529
Product name
LXS196
Purity
99.68%
Packaging
2mg
Price
$80
Updated
2021/12/16
ChemScene
Product number
CS-7529
Product name
LXS196
Purity
99.68%
Packaging
5mg
Price
$155
Updated
2021/12/16
ChemScene
Product number
CS-7529
Product name
LXS196
Purity
99.68%
Packaging
10mg
Price
$235
Updated
2021/12/16
ChemScene
Product number
CS-7529
Product name
LXS196
Purity
99.68%
Packaging
25mg
Price
$409
Updated
2021/12/16
ChemScene
Product number
CS-7529
Product name
LXS196
Purity
99.68%
Packaging
50mg
Price
$610
Updated
2021/12/16
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3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide Chemical Properties,Usage,Production

Uses

Darovasertib (LXS196) is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. Darovasertib has the potential for uveal melanoma research[1][2].

in vivo

Darovasertib (LXS196; compound 9) (15, 30, 75, 150 mg/kg, P.O., mice) shows improved efficacy (regression) in a 92.1 GNAQ uveal melanoma xenograft model in a dose-dependently manner[2].

Animal Model:Mice implanted with 92.1 GNAQ mutant uveal melanoma cells[2].
Dosage:15, 30, 75, 150 mg/kg
Administration:P.O. (bid) for 35 days
Result:Dose-dependently suppressed the tumor growth.

IC 50

PKCα: 1.9 nM (IC50); PKCθ: 0.4 nM (IC50); GSK3β: 3.1 μM (IC50)

References

[1] Protein Kinase C Inhibitor LXS196
[2] US20180179181.

3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

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3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide Suppliers

China 82 United States 7 USA 1 Global 90
Wuhan Shanhai Zhihe Biotechnology Co., Ltd.
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View Lastest Price from 3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide manufacturers

Career Henan Chemical Co
Product
3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide 1874276-76-2
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2019-12-25

1874276-76-2, 3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamideRelated Search:

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  • 3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide
  • LXS-196
  • NVP-LXS196
  • EOS-61826
  • NVP-LXS196; NVPLXS196; NVP LXS196; LXS-196; LXS 196; LXS196; LXS-196
  • IDE-196
  • LXS196,IDE196
  • 2-Pyrazinecarboxamide, 3-amino-N-[3-(4-amino-4-methyl-1-piperidinyl)-2-pyridinyl]-6-[3-(trifluoromethyl)-2-pyridinyl]-
  • Darovasertib
  • Protein kinase C,Darovasertib,IDE196,LXS-196,Inhibitor,PKC,LXS 196,IDE-196,IDE 196,inhibit
  • LXS-196 (NVP-LXS196)
  • Darovasertib (LXS-196)
  • Darovasertib, 10 mM in DMSO
  • 1874276-76-2
  • C22H23F3N8O