N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine

Product Name: N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine
CAS No.: 300842-64-2
Chemical Name: N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine
Synonyms: Acc-789;ZK 202650;NVP-ACC-789;ACC-789 (NVP-ACC789);NVP-ACC789, 10 mM in DMSO;ACC-789; ZK-202650; NVP-ACC-789;ACC789;ACC 789;N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine;N-(3-Bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine;1-Phthalazinamine, N-(3-bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-;NVP ACC789,Platelet-derived growth factor receptor,inhibit,ZK 202650,PDGFR,NVPACC789,Inhibitor,ZK-202650,ACC789,NVP-ACC789,VEGFR,ACC 789,NVP-ACC-789,Vascular endothelial growth factor receptor
CBNumber: CB72516201
Molecular Formula: C21H17BrN4
Formula Weight: 405.29
MOL File: 300842-64-2.mol

More

Less

N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Property

Boiling point:: 607.7±55.0 °C(Predicted)
Density: 1.441
storage temp.: Store at -20°C
solubility: DMSO:13.0(Max Conc. mg/mL);32.08(Max Conc. mM)
DMF:0.5(Max Conc. mg/mL);1.23(Max Conc. mM)
DMF:PBS (pH 7) (1:10):0.09(Max Conc. mg/mL);0.22(Max Conc. mM)
Ethanol:0.2(Max Conc. mg/mL);0.49(Max Conc. mM)
form: A crystalline solid
pka: 5.46±0.10(Predicted)
color: Light yellow to yellow
InChI: InChI=1S/C21H17BrN4/c1-14-6-7-16(13-19(14)22)24-21-18-5-3-2-4-17(18)20(25-26-21)12-15-8-10-23-11-9-15/h2-11,13H,12H2,1H3,(H,24,26)
InChIKey: GXWKSXUPEFVUOO-UHFFFAOYSA-N
SMILES: C1(NC2=CC=C(C)C(Br)=C2)C2=C(C=CC=C2)C(CC2C=CN=CC=2)=NN=1

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 23458
Product name: NVP-ACC789
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 23458
Product name: NVP-ACC789
Purity: ≥98%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 23458
Product name: NVP-ACC789
Purity: ≥98%
Packaging: 10mg
Price: $321
Updated: 2024/03/01

TRC

Product number: N925765
Product name: NVP-ACC789
Packaging: 2.5mg
Price: $55
Updated: 2021/12/16

TRC

Product number: N925765
Product name: NVP-ACC789
Packaging: 5mg
Price: $85
Updated: 2021/12/16

More

Less

N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Chemical Properties,Usage,Production

Uses

NVP-ACC789, is an inhibitor of human VEGFR-1, VEGFR-2 (mouse VEGFR-2), VEGFR-3 and PDGFR-β with IC50s of 0.38, 0.02 (0.23), 0.18, 1.4 μM, respectively.

in vivo

NVP-ACC789 which is given in daily oral doses for 6 days blocks VEGF-induced angiogenesis in a dose-dependent manner. NVP-ACC789 also inhibits the response to bFGF to some extent, but the dose-response curve is not linear for NVP-ACC789^[1].

IC 50

VEGFR-2: 0.02 μM (IC₅₀); VEGFR-1: 0.38 μM (IC₅₀); mVEGFR-2: 0.23 μM (IC₅₀); VEGFR-3: 0.18 μM (IC₅₀); PDGFR-β: 1.4 μM (IC₅₀)

N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine Suppliers

China 49 United States 8 Global 57

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: +86-0519-85788828 +86-13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 4032
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Shanghaizehan biopharma technology co., Ltd.

Tel: 021-61350663 13052117465
Fax: 021-61350662
Email: sales@zehanbiopharma.com
Country: China
ProdList: 977
Advantage: 55

D&C Chemicals

Tel: +86-21-58447131
Fax: +86-21-61642470
Email: 1724405207@qq.com
Country: China
ProdList: 472
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9923
Advantage: 55

Shanghai Changyan Chem & Tech Co., Ltd.

Tel: 18930833303 18930833303
Fax: +86 (21) 2024-2659
Email: sales@changyanchem.cn
Country: China
ProdList: 5001
Advantage: 55

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 9697
Advantage: 55

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

300842-64-2, N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamineRelated Search:

Infigratinib Acetanilide LMI070 NVS-PAK1-1 NVP-BSK805 NVP BGJ398 phosphate 3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide NVP-CGM097

ACC-789; ZK-202650; NVP-ACC-789;ACC789;ACC 789

N-(3-Bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine

Acc-789

ZK 202650

NVP-ACC-789

ACC-789 (NVP-ACC789)

N-(3-Bromo-4-methylphenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine

NVP ACC789,Platelet-derived growth factor receptor,inhibit,ZK 202650,PDGFR,NVPACC789,Inhibitor,ZK-202650,ACC789,NVP-ACC789,VEGFR,ACC 789,NVP-ACC-789,Vascular endothelial growth factor receptor

1-Phthalazinamine, N-(3-bromo-4-methylphenyl)-4-(4-pyridinylmethyl)-

NVP-ACC789, 10 mM in DMSO

300842-64-2