NVS-PAK1-1
- Product Name
- NVS-PAK1-1
- CAS No.
- 1783816-74-9
- Chemical Name
- NVS-PAK1-1
- Synonyms
- NVS-PAK1-1;NVS-PAK1-1 ，S8264;NVS-PAK11Chemicalbook;NVS-PAK1-1 >=98% (HPLC);NVS-PAK1-1, 10 mM in DMSO;NVS-PAK1-1, PAK1 inhibitor;NVS-PAK1-1;NVS-PAK11;NVS-PAK1 1;Inhibitor,p21 activated kinases,NVS PAK1 1,inhibit,PAK,NVS-PAK-1-1,NVSPAK11;(3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide;(S)-3-((2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl)amino)-N-isopropylpyrrolidine-1-carboxamide
- CBNumber
- CB63333615
- Molecular Formula
- C23H25ClF3N5O
- Formula Weight
- 479.93
- MOL File
- 1783816-74-9.mol
NVS-PAK1-1 Property
- Boiling point:
- 697.8±55.0 °C(Predicted)
- Density
- 1.42±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 50 mg/ml; Ethanol: 20 mg/ml
- form
- powder
- pka
- 14.02±0.40(Predicted)
- color
- white to beige
- InChIKey
- OINGHOPGNMYCAB-INIZCTEOSA-N
- SMILES
- N1(C(NC(C)C)=O)CC[C@H](NC2=NC3=CC(F)=CC=C3N(CC(F)F)C3=CC=C(Cl)C=C32)C1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML1867
- Product name
- NVS-PAK1-1
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $140.18
- Updated
- 2025/07/31
- Product number
- SML1867
- Product name
- NVS-PAK1-1
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $652
- Updated
- 2025/07/31
- Product number
- 19964
- Product name
- NVS-PAK1-1
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $121
- Updated
- 2024/03/01
- Product number
- 19964
- Product name
- NVS-PAK1-1
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $218
- Updated
- 2024/03/01
- Product number
- 19964
- Product name
- NVS-PAK1-1
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $481
- Updated
- 2024/03/01
NVS-PAK1-1 Chemical Properties,Usage,Production
Uses
NVS PAK1 1 is one of potent and selective allosteric PAK1 inhibitors.
Biochem/physiol Actions
NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay. NVS-PAK1-1 showed good selectivity against 442 other kinases including PAK2. NVS-PAK1-1 has generally good physicochemical properties, but was metabolized by rat liver microsomes, so may not be useful for in vivo work. For full characterization details, please visit the NVS-PAK1-1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc
in vivo
NVS-PAK1-1 shows a relatively poor stability in rat liver microsomes (RLM) and this would limit its application for in vivo studies (t1/2 in RLM 3.5 min)[1].
storage
Store at -20°C
NVS-PAK1-1 Preparation Products And Raw materials
Raw materials
Preparation Products
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