ChemicalBook > CAS DataBase List > NVS-PAK1-1

NVS-PAK1-1

Product Name
NVS-PAK1-1
CAS No.
1783816-74-9
Chemical Name
NVS-PAK1-1
Synonyms
NVS-PAK1-1;NVS-PAK11Chemicalbook;NVS-PAK1-1 >=98% (HPLC);NVS-PAK1-1;NVS-PAK11;NVS-PAK1 1;Inhibitor,p21 activated kinases,NVS PAK1 1,inhibit,PAK,NVS-PAK-1-1,NVSPAK11;(3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide;(S)-3-((2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl)amino)-N-isopropylpyrrolidine-1-carboxamide;1-Pyrrolidinecarboxamide, 3-[[2-chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl]amino]-N-(1-methylethyl)-, (3S)-
CBNumber
CB63333615
Molecular Formula
C23H25ClF3N5O
Formula Weight
479.93
MOL File
1783816-74-9.mol
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NVS-PAK1-1 Property

Boiling point:
697.8±55.0 °C(Predicted)
Density 
1.42±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 50 mg/ml; Ethanol: 20 mg/ml
form 
powder
pka
14.02±0.40(Predicted)
color 
white to beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1867
Product name
NVS-PAK1-1
Purity
≥98% (HPLC)
Packaging
5MG
Price
$155
Updated
2023/06/20
Sigma-Aldrich
Product number
SML1867
Product name
NVS-PAK1-1
Purity
≥98% (HPLC)
Packaging
25MG
Price
$618
Updated
2023/06/20
Cayman Chemical
Product number
19964
Product name
NVS-PAK1-1
Purity
≥98%
Packaging
5mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
19964
Product name
NVS-PAK1-1
Purity
≥98%
Packaging
10mg
Price
$218
Updated
2024/03/01
Cayman Chemical
Product number
19964
Product name
NVS-PAK1-1
Purity
≥98%
Packaging
25mg
Price
$481
Updated
2024/03/01
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NVS-PAK1-1 Chemical Properties,Usage,Production

Uses

NVS PAK1 1 is one of potent and selective allosteric PAK1 inhibitors.

Biochem/physiol Actions

NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay. NVS-PAK1-1 showed good selectivity against 442 other kinases including PAK2. NVS-PAK1-1 has generally good physicochemical properties, but was metabolized by rat liver microsomes, so may not be useful for in vivo work. For full characterization details, please visit the NVS-PAK1-1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc

storage

Store at -20°C

NVS-PAK1-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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NVS-PAK1-1 Suppliers

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1783816-74-9, NVS-PAK1-1Related Search:

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  • NVS-PAK1-1
  • (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide
  • NVS-PAK1-1;NVS-PAK11;NVS-PAK1 1
  • 1-Pyrrolidinecarboxamide, 3-[[2-chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl]amino]-N-(1-methylethyl)-, (3S)-
  • NVS-PAK1-1 >=98% (HPLC)
  • NVS-PAK11Chemicalbook
  • (S)-3-((2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl)amino)-N-isopropylpyrrolidine-1-carboxamide
  • Inhibitor,p21 activated kinases,NVS PAK1 1,inhibit,PAK,NVS-PAK-1-1,NVSPAK11
  • 1783816-74-9
  • API