NVS-PAK1-1

ChemicalBook > CAS DataBase List > NVS-PAK1-1

Product Name: NVS-PAK1-1
CAS No.: 1783816-74-9
Chemical Name: NVS-PAK1-1
Synonyms: NVS-PAK1-1;NVS-PAK11Chemicalbook;NVS-PAK1-1 >=98% (HPLC);NVS-PAK1-1;NVS-PAK11;NVS-PAK1 1;Inhibitor,p21 activated kinases,NVS PAK1 1,inhibit,PAK,NVS-PAK-1-1,NVSPAK11;(3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide;(S)-3-((2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl)amino)-N-isopropylpyrrolidine-1-carboxamide;1-Pyrrolidinecarboxamide, 3-[[2-chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl]amino]-N-(1-methylethyl)-, (3S)-
CBNumber: CB63333615
Molecular Formula: C23H25ClF3N5O
Formula Weight: 479.93
MOL File: 1783816-74-9.mol

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NVS-PAK1-1 Property

Boiling point:: 697.8±55.0 °C(Predicted)
Density: 1.42±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 50 mg/ml; Ethanol: 20 mg/ml
form: powder
pka: 14.02±0.40(Predicted)
color: white to beige

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1867
Product name: NVS-PAK1-1
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $155
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1867
Product name: NVS-PAK1-1
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $618
Updated: 2023/06/20

Cayman Chemical

Product number: 19964
Product name: NVS-PAK1-1
Purity: ≥98%
Packaging: 5mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 19964
Product name: NVS-PAK1-1
Purity: ≥98%
Packaging: 10mg
Price: $218
Updated: 2024/03/01

Cayman Chemical

Product number: 19964
Product name: NVS-PAK1-1
Purity: ≥98%
Packaging: 25mg
Price: $481
Updated: 2024/03/01

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NVS-PAK1-1 Chemical Properties,Usage,Production

Uses

NVS PAK1 1 is one of potent and selective allosteric PAK1 inhibitors.

Biochem/physiol Actions

NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay. NVS-PAK1-1 showed good selectivity against 442 other kinases including PAK2. NVS-PAK1-1 has generally good physicochemical properties, but was metabolized by rat liver microsomes, so may not be useful for in vivo work. For full characterization details, please visit the NVS-PAK1-1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc

storage

Store at -20°C

NVS-PAK1-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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1783816-74-9, NVS-PAK1-1Related Search:

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NVS-PAK1-1

(3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide

NVS-PAK1-1;NVS-PAK11;NVS-PAK1 1

1-Pyrrolidinecarboxamide, 3-[[2-chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl]amino]-N-(1-methylethyl)-, (3S)-

NVS-PAK1-1 >=98% (HPLC)

NVS-PAK11Chemicalbook

(S)-3-((2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl)amino)-N-isopropylpyrrolidine-1-carboxamide

Inhibitor,p21 activated kinases,NVS PAK1 1,inhibit,PAK,NVS-PAK-1-1,NVSPAK11

1783816-74-9

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