ChemicalBook > CAS DataBase List > T5601640

T5601640

Product Name: T5601640
CAS No.: 924473-59-6
Chemical Name: T5601640
Synonyms: T5601640;T56-LIMKi;T56-LIMKi ，S6498;T-5601640(T56-LIMKi);T56-LIMKi - T5601640;T56-LIMKi, 10 mM in DMSO;T5601640;T 5601640;T56-LIMKI;3-Methyl-N-(3-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoxazole-5-carboxamide;3-methyl-N-[3-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl]-1,2-oxazole-5-carboxamide;3-Methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-5-isoxazolecarboxamide
CBNumber: CB33163675
Molecular Formula: C19H14F3N3O3
Formula Weight: 389.33
MOL File: 924473-59-6.mol

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T5601640 Property

Boiling point:: 403.4±45.0 °C(Predicted)
Density: 1.426±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMF: 30 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 20 mg/ml
form: powder
pka: 11.41±0.70(Predicted)
color: white to beige

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Safety

RIDADR: UN 2811 6.1 / PGIII

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1305
Product name: T56-LIMKi
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $451
Updated: 2023/01/07

Sigma-Aldrich

Product number: SML1305
Product name: T56-LIMKi
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $105
Updated: 2022/05/15

Cayman Chemical

Product number: 22140
Product name: T5601640
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 22140
Product name: T5601640
Purity: ≥98%
Packaging: 5mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 22140
Product name: T5601640
Purity: ≥98%
Packaging: 10mg
Price: $189
Updated: 2024/03/01

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T5601640 Chemical Properties,Usage,Production

Uses

T 5601640 is a LIMK inhibitor and is used for the treatment of proliferative disorders such as cancer, neurofibromatosis and neuronal differentiation associated disaeses.

Biochem/physiol Actions

T56-LIMKi is a LIMK2 inhibitor that reduces phosphorylated cofilin, and induces disassembly of actin stress fibers in NF1-/- MEFs cells.

in vivo

T56-LIMKi can induce inhibition of cofilin phosphorylation and Panc-1 tumor shrinkage in vivo. Mice treated with T56-LIMKi (60 mg/kg) shows a significant decrease in tumor volume compared to control^[1].

IC 50

LIMK2

storage

Store at +4°C

T5601640 Preparation Products And Raw materials

Raw materials

Preparation Products

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T5601640 Suppliers

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Sigma-Aldrich

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924473-59-6, T5601640Related Search:

REVERSE T3 T0901317 Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)Methoxy]-

T5601640

T56-LIMKi

3-methyl-N-[3-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl]-1,2-oxazole-5-carboxamide

T-5601640(T56-LIMKi)

3-Methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-5-isoxazolecarboxamide

T5601640;T 5601640;T56-LIMKI

T56-LIMKi - T5601640

5-Isoxazolecarboxamide, 3-methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-

3-Methyl-N-(3-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoxazole-5-carboxamide

T-56-LIMKi,T56LIMKi,inhibit,T56-LIMKi,T 5601640,LIM Kinase (LIMK),LIMKs,T-5601640,Inhibitor,T56 LIMKi

T56-LIMKi, 10 mM in DMSO

T56-LIMKi ，S6498

924473-59-6