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Plecanatide

Product Name
Plecanatide
CAS No.
467426-54-6
Chemical Name
Plecanatide
Synonyms
Trulance;ATCH(1-39);Pukanatide;Plecanatide;Prikanatide;Plecanatidee;Pucanapeptide;Plecanatide impurity;Plecanatide USP/EP/BP;Plecanatide Impurtiy
CBNumber
CB33164713
Molecular Formula
C65H104N18O26S4
Formula Weight
1681.89
MOL File
467426-54-6.mol
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Plecanatide Property

Boiling point:
2120.0±65.0 °C(Predicted)
Density 
1.47±0.1 g/cm3(Predicted)
pka
3.61±0.21(Predicted)
form 
Solid
color 
White to off-white
Sequence
Asn-Asp-Glu-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu (Disulfide bridge: Cys4-Cys12; Cys7-Cys15)
InChIKey
NSPHQWLKCGGCQR-DLJDZFDSSA-N
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Safety

Hazardous Substances Data
467426-54-6(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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Plecanatide Chemical Properties,Usage,Production

Uses

Plecanatide is used in the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation. It works as a laxative by drawing water in to the gastrointestinal tract thereby softening stool and encouraging its natural passage.

brand name

Trulance

General Description

Plecanatide is an oral guanylate cyclase-C agonist that is being developed by Synergy Pharmaceuticals for the treatment of gastrointestinal disorders, such as chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). It is a synthetic analogue of human uroguanylin, a 16 amino acid peptide that regulates ion and fluid transport in the gastrointestinal tract. In January 2017, plecanatide received its first global approval in the USA for the treatment of adult patients with CIC. Plecanatide is undergoing phase III investigation in IBS-C.

Synthesis

(1) Fmoc-Leu-resin is obtained by coupling the resin solid-phase carrier and Fmoc-Leu-OH in the presence of an activator system;

(2) coupling amino acids with N-terminal Fmoc protection and side-chain protection sequentially according to the peptide order of the main chain of pukanatide by solid-phase synthesis method, specifically including the following steps:

(i) using a deprotection solution comprising piperidine and DMF in a volume ratio of 1:4 to remove the Fmoc-protecting group on the Fmoc-Leu-resin to obtain the H-Leu-resin;

(ii) in the presence of a coupling agent system, H-Leu-resin and Fmoc-protected and side-chain-protected cysteine are coupled to obtain Fmoc-Cys(Trt)-Leu-resin;

(iii) Repeat steps and to couple amino acids sequentially according to the peptide sequence of the puccinatide main chain;

(3) Cleavage, liquid-phase cyclization;

(4) purification, lyophilization to obtain puccinatide; the sequence of said puccinatide is: H-Asn-Asp-Glu-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH.

Enzyme inhibitor

This uroguanylin analogue (FW = 1681.90 g/mol; CAS 467426-54-6), also known by the codename SP-304, binds to and activates guanylate cyclase-C (GC-C) receptors (EC50 ≈ 0.3 μM) expressed on the epithelial cells lining turn sequentially activates protein kinase G-II and the chloride channel known as the Cystic Fibrosis Transmembrane-conductance Regulator (CFTR) to regulate ion and fluid transport, to promote epithelial cell homeostasis, and to maintain barrier function in the GI mucosa. Plecanatide is a hexadecapeptide that is structurally identical to uroguanylin, except for an glutamate substitution at position-3. Oral treatment with plecanatide at a dose range between 0.05-2.5 mg/kg per day is as effective as once-daily treatment with 5-amino salicylic acid (100 mg/kg) or sulfasalazine (80 mg/kg). Amelioration of colitis by the treatment with plecanatide or dolcanatide was not dose-dependent, most likely due to saturation of available GC-C receptors.

in vivo

Plecanatide (0.5 and 2.5 mg/kg, p.o.) ameliorates spontaneous and chemically induced colitis after treatment for 7 days in BALB/c mice, and 14 days in TCRα-/- mice[1].
Plecanatide (0.005-5 mg/kg, once daily for 7 days) also shows anti-inflammatory activity in dextran sulfate sodium (DSS) and trinitrobenzene sulfonic (TNBS)-induced colitis in BDF-1 mice[1].

Animal Model:Female BALB/c mice (2-4 month old) are induced colitis by TNBS[1]
Dosage:0, 0.5 and 2.5 mg/kg
Administration:P.o. for 7 days
Result:Effectively reduced colitis severity scores as compared to vehicle treatment.

Plecanatide Preparation Products And Raw materials

Raw materials

Preparation Products

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Plecanatide Suppliers

China 200 India 5 Japan 1 United States 7 Global 213
Hangzhou Peptide Biochem Co.,Ltd
Tel
0571-89197072; 18668118770
Fax
0571-89197072
Email
linda@peptide-china.com
Country
China
ProdList
233
Advantage
56
Hangzhou Xinhai Pharmaceutical Technology Co., Ltd.
Tel
571-86758863 13867485072
Fax
0571-86758863
Email
lulu@thinheal.com
Country
China
ProdList
262
Advantage
58
Zhejiang Jiekun Biotechnology Co., Ltd
Tel
88211951 13735575465
Email
sales1@gotopbio.com
Country
China
ProdList
4880
Advantage
58
Suzhou Tianma Pharma Group Tianji Bio-Pharmaceutical Co., Ltd.
Tel
0512-68322275 15850786624
Email
danielzhao@tianmapharma.com
Country
China
ProdList
30
Advantage
58
Nanjing Yuanpeptide Biotech Co.，Ltd.
Tel
18168071971
Email
support@yuan-peptide.com
Country
China
ProdList
2980
Advantage
58
Shanghai Zhuyan Biotechnology Co., Ltd.
Tel
17521259211
Email
17521259211@163.com
Country
China
ProdList
136
Advantage
58
Shanghai Fine Biotech Co.，Ltd
Tel
18221172427; 18221172427
Email
sale@fine-biotech.com
Country
China
ProdList
225
Advantage
58
Hefei Synth Biotechnology Co. LTD
Tel
0551-63802898 15395108618
Email
lixin@synthbio.cn
Country
China
ProdList
2334
Advantage
58
Alabiochem Tech.Co., Ltd.
Tel
512-58900862 400-0707518
Fax
0086-512-56765862
Email
sales@alabiochem.com
Country
China
ProdList
973
Advantage
59
Beijing HwrkChemical Technology Co., Ltd
Tel
89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9416
Advantage
55
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View Lastest Price from Plecanatide manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
Plecanatide 467426-54-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-11-13
Shanghai Joiny Pharmaceutical Co.,LTD
Product
Plecanatide 467426-54-6
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2025-10-24
Hainan Fubai Trading Co., LTD
Product
Plecanatide 467426-54-6
Price
US $1.00/g
Min. Order
10g
Purity
99
Supply Ability
999
Release date
2025-09-22

467426-54-6, PlecanatideRelated Search:

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  • Plecanatide
  • ASN-ASP-GLU-CYS-GLU-LEU-CYS-VAL-ASN-VAL-ALA-CYS-THR-GLY-CYS-LEU(DISULFIDE BOND CYS1&CYS3,CYS2&CYS4)
  • Plecanatide Impurtiy
  • L-Leucine, L-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-α-glutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (4→12),(7→15)-bis(disulfide)
  • Plecanatide impurity
  • Plecanatide USP/EP/BP
  • Prikanatide
  • ATCH(1-39)
  • Trulance
  • (4S)-4-[(2S)-2-[(2S)-2-amino-3-carbamoylpropanamido]-3-carboxypropanamido]-4-{[(1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(carbamoylmethyl)-38-{[(1S)-1-carboxy-3-methylbutyl]carbamoyl}-22-(2-carboxyethyl)-32-[(1R)-1-hydroxyethyl]-4-methyl-19-(2-methylpropyl)-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-7,13-bis(propan-2-yl)-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecaazabicyclo[14.13.13]dotetracontan-25-yl]carbamoyl}butanoic acid
  • Pukanatide
  • (S)-5-(((1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(2-Amino-2-oxoethyl)-38-(((S)-1-carboxy-3-methylbutyl)carbamoyl)-22-(2-carboxyethyl)-32-((R)-1-hydroxyethyl)-19-isobutyl-7,13-diisopropyl-4-methyl-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecaazabicyclo[14.13.13]dotetracontan-25-yl)amino)-4-((S)-3-carboxy-2-((S)-2,4-diamino-4-oxobutanamido)propanamido)-5-oxopentanoic acid
  • Plecanatidee
  • Pucanapeptide
  • (2S)-2-[[(1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(2-amino-2-oxoethyl)-25-[[(2S)-4-carboxy-2-[[(2S)-3-carboxy-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]propanoyl]amino]butanoyl]amino]-22-(2-carboxyethyl)-32-[(1R)-1-hydroxyethyl]-4-methyl-19-(2-methylpropyl)-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-7,13-di(propan-2-yl)-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecazabicyclo[14.13.13]dotetracontane-38-carbonyl]amino]-4-methylpentanoic acid
  • 467426-54-6
  • C65H104N18O26S4