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Ziconotide Polyacetate

Product Name
Ziconotide Polyacetate
CAS No.
107452-89-1
Chemical Name
Ziconotide Polyacetate
Synonyms
snx111;Ziconotide;ω-conotoxin mviia;OMEGA-CGTX MVII A;o-Conotoxin MVIIA;Zicontide Acetate;ω-Conotoxin MVIIA;ZICONOTIDE ACETATE;SNX-111, Ziconotide;OMEGA-CONOTOXIN MVIIA
CBNumber
CB3190092
Molecular Formula
C102H172N36O32S7
Formula Weight
2639.13
MOL File
107452-89-1.mol
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Ziconotide Polyacetate Property

Density 
1.60±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO (Slightly, Sonicated), Methanol (Slightly)
form 
Solid
color 
White to Off-White
InChIKey
BPKIMPVREBSLAJ-QTBYCLKRSA-N
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Safety

RIDADR 
3172
WGK Germany 
3
HazardClass 
6.1(b)
PackingGroup 
III
Hazardous Substances Data
107452-89-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C1182
Product name
ω-Conotoxin MVIIA
Purity
≥95% (HPLC)
Packaging
0.1mg
Price
$260
Updated
2022/05/15
Sigma-Aldrich
Product number
C1182
Product name
ω-Conotoxin MVIIA
Purity
≥95% (HPLC)
Packaging
0.5mg
Price
$938
Updated
2022/05/15
TRC
Product number
Z385000
Product name
ZiconotidePolyacetate
Packaging
2.5mg
Price
$3390
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC110295
Product name
Omega-Conotoxin MVIIA
Packaging
500ug
Price
$600
Updated
2021/12/16
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Ziconotide Polyacetate Chemical Properties,Usage,Production

Description

ω-conotoxin MVIIA, also knwn as Ziconotide acetate, is a peptide consisting of 25 amino acid.  It is a disulfide-bridged polypeptide from the venom of the sea snail Conusmagus that binds to neuronal N-type calcium channels. It forms a compact folded structure, presenting a loop between Cys8 and Cys15 that contains a set of residues critical for its binding. Both ω-conotoxins GVIA and MVIIA could bind to neuronal N-type calcium channels. ω-conotoxin GVIA is rich in hydroxyl groups while ω-conotoxin MVIIA contains a large number of positively charged side chains[1-2].

Uses

Ziconotide acetate (ω-Conotoxin MVIIA), the peptide toxin of the Conus magus (cone snail) is a selective antagonist of N-type voltage sensitive calcium channels (VSCC). As a most well-known identified conotoxin so far, it has been used as a effective drug to treat intractable chronic pain in cancer and ADIS patients[2]. Blocks neurotransmitter release by preventing depolarization-induced calcium influx. Used as a ligand for binding studies of voltage sensitive calcium channels. Analgesic; neuroprotective.

brand name

Prialt (Elan).

General Description

ω-Conotoxin MVIIA functions as a selective inhibitor of N-type voltage-sensitive calcium channels (VSCCs). It has analgesic and neuroprotective effects. ω-Conotoxin MVIIA is used to treat neuropathic pain.

Biochem/physiol Actions

Neuronal N-type Ca2+ channel blocker in mammalian and amphibian brain; blocks release of GABA and glutamate at neuronal synapses.

References

[1] Wang R, et al. Development of an ic-ELISA and immunochromatographic strip based on IgG antibody for detection of ω-conotoxin MVIIA. Journal of Hazardous Materials, 2019; 378: 120510.
[2] Zhou Y, et al. A Chemoenzymatic Approach To Produce a Cyclic Analogue of the Analgesic Drug MVIIA (Ziconotide). Angew. Chem. Int. Ed., 2023; 62: e202302812.

Ziconotide Polyacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ziconotide Polyacetate Suppliers

China 175 France 2 Germany 2 Japan 1 South Korea 1 Switzerland 2 United Kingdom 1 United States 19 Global 203
Hangzhou Xinhai Pharmaceutical Technology Co., Ltd.
Tel
0571-86758863 13867485072
Fax
0571-86758863
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lulu@thinheal.com
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China
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Shaoxing Junyu Biotechnology Co., LTD
Tel
0571-88211921 15572296305
Email
sales4@gotopbio.com
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China
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Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd
Tel
18014456767 18014456767
Email
wenxi@jszkhy.com
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China
ProdList
1350
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Nanjing Yuanpeptide Biotech Co.，Ltd.
Tel
18168071971
Email
support@yuan-peptide.com
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China
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2978
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J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
ProdList
96815
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Alabiochem Tech.Co., Ltd.
Tel
0512-58900862 400-0707518
Fax
0086-512-56765862
Email
sales@alabiochem.com
Country
China
ProdList
995
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Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
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China
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GL Biochem (Shanghai) Ltd
Tel
21-61263452 13641803416
Fax
86-21-61263399
Email
ymbetter@glbiochem.com
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China
ProdList
9981
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Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
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Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
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View Lastest Price from Ziconotide Polyacetate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Ziconotide acetate 107452-89-1
Price
US $0.00/mg
Min. Order
1mg
Purity
99%
Supply Ability
10kg/month
Release date
2021-07-20
Wuhan Haorong Biotechnology Co.,Ltd
Product
Ziconotide acetate 107452-89-1
Price
US $0.00-0.00/kg
Min. Order
20kg
Purity
99%
Supply Ability
200000
Release date
2023-08-21
Shanghai Affida new material science and technology center
Product
Zicontide Acetate 107452-89-1
Price
US $0.00-0.00/box
Min. Order
1box
Purity
99
Supply Ability
50000KG/month
Release date
2024-06-17

107452-89-1, Ziconotide PolyacetateRelated Search:

Z-GLU(OTBU)-OH DCHA Linaclotide Liraglutide Vinyl acetate Sodium acetate Ethyl acetate Exenatide acetate Glatiramer acetate Potassium Acetate Methyl acetate Octreotide acetate Tocopheryl acetate Butyl acetate N-Cbz-L-Glutamic acid 5-tert-butyl ester ACETATE H-PHE-BETA-ALA-OH H-TYR-BETA-ALA-OH H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2

  • OMEGA-CONOTOXIN MVIIA
  • OMEGA-CGTX MVII A
  • ZICONOTIDE ACETATE
  • snx111
  • H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2
  • H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2 (DISULFIDE BRIDGE: 1-16, 8-20, AND 15-25)
  • CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2
  • CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (DISULFIDE BRIDGE: 1-16,8-20, AND 15-25)
  • ω-conotoxin mviia
  • omega-conopeptide MVIIA
  • SNX-111, Ziconotide
  • omega-Conopeptide MVIIA (Conus)
  • Ziconotide
  • H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2, disulfid bridges 1-16/8-20/15-25
  • REF DUPL: H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2, disulfid bridges 1-16/8-20/15-25
  • Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys -Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2(Disulfide,Cys1-Cys16, Cys8-Cys20,Cys15-Cys25)
  • Ziconotide [USAN:INN]
  • CONOTOXIN MVII A (Omega-)
  • o-Conotoxin MVIIA
  • Zicontide Acetate
  • L-Cysteinamide, L-cysteinyl-L-lysylglycyl-L-lysylglycyl-L-alanyl-L-lysyl-L-cysteinyl-L-seryl-L-arginyl-L-leucyl-L-methionyl-L-tyrosyl-L-α-aspartyl-L-cysteinyl-L-cysteinyl-L-threonylglycyl-L-seryl-L-cysteinyl-L-arginyl-L-serylglycyl-L-lysyl-, cyclic (1→16),(8→20),(15→25)-tris(disulfide)
  • Ziconotide acetate USP/EP/BP
  • ω-Conotoxin MVIIA
  • Ziconotide Polyacetate
  • 107452-89-1
  • 107425-89-1
  • 914451-03-8
  • C102H172N36O32S7
  • C102H172N36O32S7C2H4O2
  • Cell Biology
  • Calcium Channel Modulators
  • Peptide Toxins
  • Ion Channels
  • Voltage-gated Ion Channels
  • Cell Signaling and Neuroscience
  • BioChemical
  • Peptide
  • 107452-89-1