Ziconotide Polyacetate
- Product Name
- Ziconotide Polyacetate
- CAS No.
- 107452-89-1
- Chemical Name
- Ziconotide Polyacetate
- Synonyms
- snx111;Ziconotide;ω-conotoxin mviia;OMEGA-CGTX MVII A;o-Conotoxin MVIIA;Zicontide Acetate;ω-Conotoxin MVIIA;ZICONOTIDE ACETATE;SNX-111, Ziconotide;OMEGA-CONOTOXIN MVIIA
- CBNumber
- CB3190092
- Molecular Formula
- C102H172N36O32S7
- Formula Weight
- 2639.13
- MOL File
- 107452-89-1.mol
Ziconotide Polyacetate Property
- Density
- 1.60±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO (Slightly, Sonicated), Methanol (Slightly)
- form
- Solid
- color
- White to Off-White
- InChIKey
- BPKIMPVREBSLAJ-QTBYCLKRSA-N
Safety
- RIDADR
- 3172
- WGK Germany
- 3
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 107452-89-1(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- C1182
- Product name
- ω-Conotoxin MVIIA
- Purity
- ≥95% (HPLC)
- Packaging
- 0.1mg
- Price
- $260
- Updated
- 2022/05/15
- Product number
- C1182
- Product name
- ω-Conotoxin MVIIA
- Purity
- ≥95% (HPLC)
- Packaging
- 0.5mg
- Price
- $938
- Updated
- 2022/05/15
- Product number
- Z385000
- Product name
- ZiconotidePolyacetate
- Packaging
- 2.5mg
- Price
- $3390
- Updated
- 2021/12/16
- Product number
- FC110295
- Product name
- Omega-Conotoxin MVIIA
- Packaging
- 500ug
- Price
- $600
- Updated
- 2021/12/16
Ziconotide Polyacetate Chemical Properties,Usage,Production
Description
ω-conotoxin MVIIA, also knwn as Ziconotide acetate, is a peptide consisting of 25 amino acid. It is a disulfide-bridged polypeptide from the venom of the sea snail Conusmagus that binds to neuronal N-type calcium channels. It forms a compact folded structure, presenting a loop between Cys8 and Cys15 that contains a set of residues critical for its binding. Both ω-conotoxins GVIA and MVIIA could bind to neuronal N-type calcium channels. ω-conotoxin GVIA is rich in hydroxyl groups while ω-conotoxin MVIIA contains a large number of positively charged side chains[1-2].
Uses
Ziconotide acetate (ω-Conotoxin MVIIA), the peptide toxin of the Conus magus (cone snail) is a selective antagonist of N-type voltage sensitive calcium channels (VSCC). As a most well-known identified conotoxin so far, it has been used as a effective drug to treat intractable chronic pain in cancer and ADIS patients[2]. Blocks neurotransmitter release by preventing depolarization-induced calcium influx. Used as a ligand for binding studies of voltage sensitive calcium channels. Analgesic; neuroprotective.
brand name
Prialt (Elan).
General Description
ω-Conotoxin MVIIA functions as a selective inhibitor of N-type voltage-sensitive calcium channels (VSCCs). It has analgesic and neuroprotective effects. ω-Conotoxin MVIIA is used to treat neuropathic pain.
Biochem/physiol Actions
Neuronal N-type Ca2+ channel blocker in mammalian and amphibian brain; blocks release of GABA and glutamate at neuronal synapses.
References
[1] Wang R, et al. Development of an ic-ELISA and immunochromatographic strip based on IgG antibody for detection of ω-conotoxin MVIIA. Journal of Hazardous Materials, 2019; 378: 120510.
[2] Zhou Y, et al. A Chemoenzymatic Approach To Produce a Cyclic Analogue of the Analgesic Drug MVIIA (Ziconotide). Angew. Chem. Int. Ed., 2023; 62: e202302812.
Ziconotide Polyacetate Preparation Products And Raw materials
Raw materials
Preparation Products
Ziconotide Polyacetate Suppliers
View Lastest Price from Ziconotide Polyacetate manufacturers
- Product
- Ziconotide acetate 107452-89-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 200000
- Release date
- 2023-08-21
- Product
- Ziconotide Polyacetate 107452-89-1
- Price
- US $70.00-700.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-27
- Product
- Ziconotide Polyacetate 107452-89-1
- Price
- US $8.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-29