Ziconotide Polyacetate

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Ziconotide Polyacetate

Product Name: Ziconotide Polyacetate
CAS No.: 107452-89-1
Chemical Name: Ziconotide Polyacetate
Synonyms: snx111;Ziconotide;ω-conotoxin mviia;OMEGA-CGTX MVII A;o-Conotoxin MVIIA;Zicontide Acetate;ω-Conotoxin MVIIA;ZICONOTIDE ACETATE;SNX-111, Ziconotide;OMEGA-CONOTOXIN MVIIA
CBNumber: CB3190092
Molecular Formula: C102H172N36O32S7
Formula Weight: 2639.13
MOL File: 107452-89-1.mol

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Ziconotide Polyacetate Property

Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO (Slightly, Sonicated), Methanol (Slightly)
form: Solid
color: White to Off-White
InChIKey: BPKIMPVREBSLAJ-QTBYCLKRSA-N

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Safety

RIDADR: 3172
WGK Germany: 3
HazardClass: 6.1(b)
PackingGroup: III
Hazardous Substances Data: 107452-89-1(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C1182
Product name: ω-Conotoxin MVIIA
Purity: ≥95% (HPLC)
Packaging: 0.1mg
Price: $260
Updated: 2022/05/15

Sigma-Aldrich

Product number: C1182
Product name: ω-Conotoxin MVIIA
Purity: ≥95% (HPLC)
Packaging: 0.5mg
Price: $938
Updated: 2022/05/15

TRC

Product number: Z385000
Product name: ZiconotidePolyacetate
Packaging: 2.5mg
Price: $3390
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC110295
Product name: Omega-Conotoxin MVIIA
Packaging: 500ug
Price: $600
Updated: 2021/12/16

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Ziconotide Polyacetate Chemical Properties,Usage,Production

Description

ω-conotoxin MVIIA, also knwn as Ziconotide acetate, is a peptide consisting of 25 amino acid. It is a disulfide-bridged polypeptide from the venom of the sea snail Conusmagus that binds to neuronal N-type calcium channels. It forms a compact folded structure, presenting a loop between Cys8 and Cys15 that contains a set of residues critical for its binding. Both ω-conotoxins GVIA and MVIIA could bind to neuronal N-type calcium channels. ω-conotoxin GVIA is rich in hydroxyl groups while ω-conotoxin MVIIA contains a large number of positively charged side chains[1-2].

Uses

Ziconotide acetate (ω-Conotoxin MVIIA), the peptide toxin of the Conus magus (cone snail) is a selective antagonist of N-type voltage sensitive calcium channels (VSCC). As a most well-known identified conotoxin so far, it has been used as a effective drug to treat intractable chronic pain in cancer and ADIS patients[2]. Blocks neurotransmitter release by preventing depolarization-induced calcium influx. Used as a ligand for binding studies of voltage sensitive calcium channels. Analgesic; neuroprotective.

brand name

Prialt (Elan).

General Description

ω-Conotoxin MVIIA functions as a selective inhibitor of N-type voltage-sensitive calcium channels (VSCCs). It has analgesic and neuroprotective effects. ω-Conotoxin MVIIA is used to treat neuropathic pain.

Biochem/physiol Actions

Neuronal N-type Ca2+ channel blocker in mammalian and amphibian brain; blocks release of GABA and glutamate at neuronal synapses.

References

[1] Wang R, et al. Development of an ic-ELISA and immunochromatographic strip based on IgG antibody for detection of ω-conotoxin MVIIA. Journal of Hazardous Materials, 2019; 378: 120510.
[2] Zhou Y, et al. A Chemoenzymatic Approach To Produce a Cyclic Analogue of the Analgesic Drug MVIIA (Ziconotide). Angew. Chem. Int. Ed., 2023; 62: e202302812.

Ziconotide Polyacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ziconotide Polyacetate manufacturers

Wuhan Haorong Biotechnology Co.,Ltd

Product: Ziconotide acetate 107452-89-1
Price: US $0.00-0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 200000
Release date: 2023-08-21

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Ziconotide Polyacetate 107452-89-1
Price: US $70.00-700.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-27

Henan Fengda Chemical Co., Ltd

Product: Ziconotide Polyacetate 107452-89-1
Price: US $8.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-03-29

107452-89-1, Ziconotide PolyacetateRelated Search:

Z-GLU(OTBU)-OH DCHA Linaclotide Liraglutide Vinyl acetate Sodium acetate Ethyl acetate Exenatide acetate Glatiramer acetate Potassium Acetate Methyl acetate Octreotide acetate Tocopheryl acetate Butyl acetate N-Cbz-L-Glutamic acid 5-tert-butyl ester ACETATE H-PHE-BETA-ALA-OH H-TYR-BETA-ALA-OH H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2

OMEGA-CONOTOXIN MVIIA

OMEGA-CGTX MVII A

ZICONOTIDE ACETATE

snx111

H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2

H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2 (DISULFIDE BRIDGE: 1-16, 8-20, AND 15-25)

CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2

CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (DISULFIDE BRIDGE: 1-16,8-20, AND 15-25)

ω-conotoxin mviia

omega-conopeptide MVIIA

SNX-111, Ziconotide

omega-Conopeptide MVIIA (Conus)

Ziconotide

H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2, disulfid bridges 1-16/8-20/15-25

REF DUPL: H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2, disulfid bridges 1-16/8-20/15-25

Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys -Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2(Disulfide,Cys1-Cys16, Cys8-Cys20,Cys15-Cys25)

Ziconotide [USAN:INN]

CONOTOXIN MVII A (Omega-)

o-Conotoxin MVIIA

Zicontide Acetate

L-Cysteinamide, L-cysteinyl-L-lysylglycyl-L-lysylglycyl-L-alanyl-L-lysyl-L-cysteinyl-L-seryl-L-arginyl-L-leucyl-L-methionyl-L-tyrosyl-L-α-aspartyl-L-cysteinyl-L-cysteinyl-L-threonylglycyl-L-seryl-L-cysteinyl-L-arginyl-L-serylglycyl-L-lysyl-, cyclic (1→16),(8→20),(15→25)-tris(disulfide)

Ziconotide acetate USP/EP/BP

ω-Conotoxin MVIIA

Ziconotide Polyacetate

107452-89-1

107425-89-1

914451-03-8

C102H172N36O32S7

C102H172N36O32S7C2H4O2

Cell Biology

Calcium Channel Modulators

Peptide Toxins

Ion Channels

Voltage-gated Ion Channels

Cell Signaling and Neuroscience

BioChemical

Peptide

107452-89-1