ChemicalBook > CAS DataBase List > Albendazole S-oxide

Albendazole S-oxide

Product Name
Albendazole S-oxide
CAS No.
54029-12-8
Chemical Name
Albendazole S-oxide
Synonyms
RICOBENDAZOLE;ALBENDAZOLE SULFOXIDE;ALBENDAZOLE OXIDE;RS-8852;Rycobendzole;RicobendazoL;RECOBENDAZOLE;RICOBENDAZOLEC;albendazole s-oxide;Albendazole-EP-Imp-B
CBNumber
CB3319817
Molecular Formula
C12H15N3O3S
Formula Weight
281.33
MOL File
54029-12-8.mol
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Albendazole S-oxide Property

Melting point:
226-228°C dec.
Density 
1.40
storage temp. 
Sealed in dry,2-8°C
solubility 
Chloroform (Slightly, Heated), Methanol (Slightly)
form 
Solid
pka
pKa 3.28±0.01(H2O t=25.0±0.1 I=0.1(NaCl))(Approximate); 9.93±0.01(H2O t=25.0±0.1 I=0.1(NaCl))(Approximate)
color 
colorless or white
Water Solubility 
62mg/L(25 ºC)
BRN 
677664
InChIKey
VXTGHWHFYNYFFV-UHFFFAOYSA-N
CAS DataBase Reference
54029-12-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
24/25
WGK Germany 
3
RTECS 
FD1080000
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H373May cause damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SMB01325
Product name
Albendazole sulfoxide
Purity
≥97% (HPLC)
Packaging
100MG
Price
$133
Updated
2025/07/31
Sigma-Aldrich
Product number
35395
Product name
Albendazole sulfoxide
Purity
VETRANAL
Packaging
10mg
Price
$307
Updated
2025/07/31
TCI Chemical
Product number
A3316
Product name
Albendazole Sulfoxide
Packaging
5G
Price
$24
Updated
2025/07/31
TCI Chemical
Product number
A3316
Product name
Albendazole Sulfoxide
Packaging
25G
Price
$70
Updated
2025/07/31
Cayman Chemical
Product number
21880
Product name
Ricobendazole
Purity
≥98%
Packaging
5g
Price
$44
Updated
2024/03/01
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Albendazole S-oxide Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Powder

Uses

A metabolite of Albendazole, an anthelmintic

Uses

Tubulin polymerization or assembled inhibitors

Definition

ChEBI: Albendazole S-oxide is a sulfoxide. It is functionally related to an albendazole.

Biological Activity

Ricobendazole is a key metabolite of albendazole and acts as an anthelmintic. It has been shown to induce apoptosis in human cancer cell line HT-29, possibly by arresting cell cycle at the G2/M phase.

Synthesis

34840-23-8

66868-66-4

54029-12-8

3.56 g (18 mmol) of 4-(1-propylsulfinyl)-1,2-diaminobenzene was dissolved in 45 mL of methanol and 1.03 mL of acetic acid and 3.84 g (19.8 mmol) of 1,3-bis(methoxycarbonyl)-S-methylisothiourea were added. The reaction mixture was heated to reflux for 2.5 hours, followed by cooling and removing the solvent under reduced pressure. The resulting white solid was digested with water, filtered, washed with ether and dried to give 4.1 g of white solid product, albendazole sulfoxide, with a melting point of 205°C to 216°C and a yield of 81%.

in vivo

Albendazole sulfoxide (0.5 mg/kg, i.m., BID, 15 days) reduces cyst size and weight in Balb/c mice infected with protoscoleces[3].

References

[1] Patent: US4076825, 1978, A

Albendazole S-oxide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Albendazole S-oxide manufacturers

Wuhan JiyunZen Tech Co., Ltd.
Product
Albendazole S-oxide 54029-12-8
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-05-06
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Albendazole Sulfoxide HCl 54029-12-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2024-03-29
Hebei Yanxi Chemical Co., Ltd.
Product
Albendazole S-oxide 54029-12-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2023-09-20

54029-12-8, Albendazole S-oxideRelated Search:

Triclabendazole sulfoxide ETHYLENE OXIDE Bensulfuron methyl Methylparaben METHYL THIOPHENE-2-CARBOXYLATE Methyl anthranilate Methyl formate Zinc oxide Benzimidazole Kresoxim-methyl Methyl acrylate Methyl benzoate Iron oxide Lithium oxide NITRIC OXIDE Chlorpropham Thiophanate-methyl Aluminum oxide

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