Albendazole S-oxide
- Product Name
- Albendazole S-oxide
- CAS No.
- 54029-12-8
- Chemical Name
- Albendazole S-oxide
- Synonyms
- RICOBENDAZOLE;ALBENDAZOLE SULFOXIDE;ALBENDAZOLE OXIDE;RS-8852;Rycobendzole;RicobendazoL;RECOBENDAZOLE;RICOBENDAZOLEC;albendazole s-oxide;Albendazole-EP-Imp-B
- CBNumber
- CB3319817
- Molecular Formula
- C12H15N3O3S
- Formula Weight
- 281.33
- MOL File
- 54029-12-8.mol
Albendazole S-oxide Property
- Melting point:
- 226-228°C dec.
- Density
- 1.40
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Chloroform (Slightly, Heated), Methanol (Slightly)
- form
- Solid
- pka
- pKa 3.28±0.01(H2O t=25.0±0.1 I=0.1(NaCl))(Approximate); 9.93±0.01(H2O t=25.0±0.1 I=0.1(NaCl))(Approximate)
- color
- colorless or white
- Water Solubility
- 62mg/L(25 ºC)
- BRN
- 677664
- InChIKey
- VXTGHWHFYNYFFV-UHFFFAOYSA-N
- CAS DataBase Reference
- 54029-12-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H373May cause damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SMB01325
- Product name
- Albendazole sulfoxide
- Purity
- ≥97% (HPLC)
- Packaging
- 100MG
- Price
- $133
- Updated
- 2025/07/31
- Product number
- 35395
- Product name
- Albendazole sulfoxide
- Purity
- VETRANAL
- Packaging
- 10mg
- Price
- $307
- Updated
- 2025/07/31
- Product number
- A3316
- Product name
- Albendazole Sulfoxide
- Packaging
- 5G
- Price
- $24
- Updated
- 2025/07/31
- Product number
- A3316
- Product name
- Albendazole Sulfoxide
- Packaging
- 25G
- Price
- $70
- Updated
- 2025/07/31
- Product number
- 21880
- Product name
- Ricobendazole
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $44
- Updated
- 2024/03/01
Albendazole S-oxide Chemical Properties,Usage,Production
Chemical Properties
White to Off-White Powder
Uses
A metabolite of Albendazole, an anthelmintic
Uses
Tubulin polymerization or assembled inhibitors
Definition
ChEBI: Albendazole S-oxide is a sulfoxide. It is functionally related to an albendazole.
Biological Activity
Ricobendazole is a key metabolite of albendazole and acts as an anthelmintic. It has been shown to induce apoptosis in human cancer cell line HT-29, possibly by arresting cell cycle at the G2/M phase.
Synthesis
34840-23-8
66868-66-4
54029-12-8
3.56 g (18 mmol) of 4-(1-propylsulfinyl)-1,2-diaminobenzene was dissolved in 45 mL of methanol and 1.03 mL of acetic acid and 3.84 g (19.8 mmol) of 1,3-bis(methoxycarbonyl)-S-methylisothiourea were added. The reaction mixture was heated to reflux for 2.5 hours, followed by cooling and removing the solvent under reduced pressure. The resulting white solid was digested with water, filtered, washed with ether and dried to give 4.1 g of white solid product, albendazole sulfoxide, with a melting point of 205°C to 216°C and a yield of 81%.
in vivo
Albendazole sulfoxide (0.5 mg/kg, i.m., BID, 15 days) reduces cyst size and weight in Balb/c mice infected with protoscoleces[3].
References
[1] Patent: US4076825, 1978, A
Albendazole S-oxide Preparation Products And Raw materials
Raw materials
Preparation Products
Albendazole S-oxide Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
View Lastest Price from Albendazole S-oxide manufacturers
- Product
- Albendazole S-oxide 54029-12-8
- Price
- US $5.00-0.50/KG
- Min. Order
- 1KG
- Purity
- 99% hplc
- Supply Ability
- 500TONS
- Release date
- 2025-05-06
- Product
- Albendazole Sulfoxide HCl 54029-12-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2024-03-29
- Product
- Albendazole S-oxide 54029-12-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2023-09-20