Description References
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SALUBRINAL

Description References
Product Name
SALUBRINAL
CAS No.
405060-95-9
Chemical Name
SALUBRINAL
Synonyms
SAL;CS-1008;ubrinaL;SALUBRINAL;EIF-2Α INHIBITOR;SALUBRINAL USP/EP/BP;N-(2,2,2-Trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnAmamide;(E)-1-(quinolin-8-yl)-3-(2,2,2-trichloro-1-cinnamamidoethyl)thiourea;(E)-N-(2,2,2-Trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnamamide;(E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide
CBNumber
CB3322523
Molecular Formula
C21H17Cl3N4OS
Formula Weight
479.81
MOL File
405060-95-9.mol
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SALUBRINAL Property

Melting point:
>160°C (dec.)
Density 
1.474±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
10.70±0.70(Predicted)
color 
white to light yellow to light gray
Water Solubility 
Insoluble in water.
Sensitive 
Light Sensitive
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0951
Product name
Salubrinal
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0951
Product name
Salubrinal
Purity
≥98% (HPLC)
Packaging
25mg
Price
$478
Updated
2024/03/01
Alfa Aesar
Product number
J64192
Product name
Salubrinal
Packaging
5mg
Price
$121
Updated
2023/06/20
Alfa Aesar
Product number
J64192
Product name
Salubrinal
Packaging
10mg
Price
$200
Updated
2023/06/20
Cayman Chemical
Product number
14735
Product name
Salubrinal
Purity
≥95%
Packaging
1mg
Price
$26
Updated
2024/03/01
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SALUBRINAL Chemical Properties,Usage,Production

Description

Selective eukaryotic translation initiation factor 2 subunit α (elF2α) dephosphorylation inhibitor. Salubrinal is a selective Inhibitor of eIF2α (eukaryotic translation initiation factor 2 α-subunit) dephosphorylation, and is primarily used experimentally, to study stress responses in eukaryotic cells associated with the action of eIF2. Salubrinal indirectly inhibits eIF2 as a result of reduced dephosphorylation of its α-subunit resulting in activation of stress response pathways usually triggered by events such as oxidative stress or buildup of unfolded protein in the endoplasmic reticulum. Salubrinal can protect PC12 cells from endoplasmic reticulum stress-mediated apoptosis (EC50 = 15 μM) and prevent replication of herpes virus (IC50 = 3 μM), by inhibiting dephosphorylation of eIF2α. As eIF2α has a role in bone formation, salubrinal is also being studied for its effects in osteoporosis. Besides, it also shows potential neuroprotective actions. Although salubrinal has putative therapeutic value due to its function, it is as yet only used experimentally.

References

1. https://en.wikipedia.org/wiki/Salubrinal
2. http://www.sigmaaldrich.com/catalog/product/sigma/sml0951?lang=en&region=CA
3. https://www.tocris.com/dispprod.php?ItemId=143907#.WQfadeyECP0
4. http://www.selleckchem.com/products/salubrinal.html
5. https://www.caymanchem.com/product/14735
6. https://www.hellobio.com/salubrinal.html

Description

Salubrinal is a selective phosphatase inhibitor that prevents dephosphorylation of eukaryotic translation initiation factor 2 subunit α (eIF2α), protecting PC12 cells from endoplasmic reticulum stress-mediated apoptosis (EC50 = 15 μM). It appears to block the action of protein phosphatase 1 (PP1) on eIF2α although it does not mimic calyculin A, another PP1-selective inhibitor, in toxicity or phosphorylation pattern. Salubrinal also prevents replication of herpes virus (IC50 = 3 μM), by inhibiting dephosphorylation of eIF2α. As eIF2α has a role in bone formation, salubrinal is being studied for its effects in osteoporosis.

Uses

Salubrinal has been used to study the effect of stress-protective genes and pathways on organism development and lifespan. It has also been used to study the therapeutic potential of salubrinal in methamphetamine induced blood–brain barrier disruption.

Uses

Salubrinal is an endoplasmic reticulum stress blocker that modulates sleep homeostasis and activation of sleep- and wake-regulatory neurons

Uses

Salubrinal is a selective Inhibitor of eIF2α (eukaryotic translation initiation factor 2 α-subunit) dephosphorylation, inhibiting global protein translation. Salubrinal is a specific inhibitor of ER Stress induced apoptosis.

Definition

ChEBI: A member of the class of quinolines that is a mixed aminal resulting from the formal condensation oftrichloroacetaldehyde with the amide nitrogen of trans-cinnamamide and the primary amino group of 1-quinolin-8-ylthiourea. It is a selective in ibitor of cellular complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha).

Biological Activity

Cell-permeable, selective inhibitor of cellular phosphatase complexes that dephosphorylate eukaryotic translation initiation factor 2 subunit α (eIF2 α ). Protects cells from endoplasmic reticulum stress-induced apoptosis (EC 50 ~ 15 μ M).

Biochem/physiol Actions

Salubrinal is a selective Inhibitor of eIF2α (eukaryotic translation initiation factor 2 α-subunit) dephosphorylation, inhibiting global protein translation. Salubrinal is a specific inhibitor of ER Stress induced apoptosis.

storage

+4°C

References

1) Boyce?et al. (2005)?A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress; Science,?307?935 2) Kessel (2006)?Protection of Bcl-2 by salubrinal; Biochem. Biophys. Res. Commun.,?346?1320 3) He?et al. (2013)?Osteoporosis regulation by salubrinal through eFI27alpha; mediated differentiation of osteoclast and osteoblast; Cell. Signal.,?25?552

SALUBRINAL Preparation Products And Raw materials

Raw materials

Preparation Products

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SALUBRINAL Suppliers

Canada 1 China 87 Europe 1 Germany 1 India 2 Switzerland 1 United Kingdom 4 United States 21 Global 118
VDM Biochemicals
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857-239-0968
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Musechem
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+1-800-259-7612
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+1-800-259-7612
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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InvivoChem
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Cckinase, Inc.
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Aladdin Scientific
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sales@aladdinsci.com
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TargetMol Chemicals Inc.
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ApexBio Technology
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Cayman Chemical Company
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United States Biological
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View Lastest Price from SALUBRINAL manufacturers

Career Henan Chemical Co
Product
SALUBRINAL 405060-95-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kgs
Release date
2019-12-17

405060-95-9, SALUBRINALRelated Search:

20ALPHA-HYDROXYCHOLESTEROL SB 203580 CHIR-99021 LDN 193189 hydrochloride Sulfate Sodium sulfide Taurine Bismuth MLN9708 CYCLOPAMINE GSK2656157 7Methyl-5-(1-{[3-(trifluoroMethyl)phenyl]acetyl}-2,3-dihydro1Hindol-5-yl)7Hpyrrolo[2,3d]pyriMidin-4-aMine ABT 263 Rapamycin SALUBRINAL

  • (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
  • 2-Propenamide, 3-phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-, (2E)-
  • (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide Salubrinal
  • Salubrinal (2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
  • (E)-3-phenyl-N-[2,2,2-trichloro-1-(quinolin-8-ylcarbamothioylamino)ethyl]prop-2-enamide
  • N-(2,2,2-Trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnAmamide
  • SALUBRINAL
  • SAL
  • 3-PHENYL-N-[2,2,2-TRICHLORO-1-[[(8-QUINOLINYLAMINO)THIOXOMETHYL]AMINO]ETHYL]-2-PROPENAMIDE
  • (E)-1-(quinolin-8-yl)-3-(2,2,2-trichloro-1-cinnamamidoethyl)thiourea
  • EIF-2Α INHIBITOR
  • CS-1008
  • ubrinaL
  • SALUBRINAL USP/EP/BP
  • (E)-N-(2,2,2-Trichloro-1-(3-(quinolin-8-yl)thioureido)ethyl)cinnamamide
  • 405060-95-9
  • C21H17Cl3N4OS
  • C21H17N4OSCl3
  • Inhibitors
  • Apoptosis Inhibitors