MLN9708

Product Name: MLN9708
CAS No.: 1201902-80-8
Chemical Name: MLN9708
Synonyms: MLN9708;CS-1830;Ninlaro);MLN 9708 analog;MLN-9708 analog;MLN9708;MLN-9708;Ixazomib Citrate;Esazomide citrate;MLN9708,MLN-9708,MLN 9708;MLN 9708 - Ixazomib citrate
CBNumber: CB82521079
Molecular Formula: C20H23BCl2N2O9
Formula Weight: 517.12
MOL File: 1201902-80-8.mol

More

Less

MLN9708 Property

Melting point:: >227°C (dec.)
Density: 1.47
storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
pka: 1.92±0.20(Predicted)
form: Solid
color: White to Off-White

More

Less

Safety

Safety Statements: 24/25
HS Code: 29329990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 18386
Product name: MLN9708
Purity: ≥95%
Packaging: 5mg
Price: $60
Updated: 2024/03/01

Cayman Chemical

Product number: 18386
Product name: MLN9708
Purity: ≥95%
Packaging: 1mg
Price: $43
Updated: 2023/06/20

Cayman Chemical

Product number: 18386
Product name: MLN9708
Purity: ≥95%
Packaging: 10mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 18386
Product name: MLN9708
Purity: ≥95%
Packaging: 50mg
Price: $208
Updated: 2024/03/01

TRC

Product number: M425158
Product name: MLN-9708
Packaging: 50mg
Price: $180
Updated: 2021/12/16

More

Less

MLN9708 Chemical Properties,Usage,Production

Description

Ixazomib citrate is a proteasome inhibitor prodrug for the treatment of multiple myeloma in patients who have received at least one prior therapy in combination with lenalidomide and dexamethasone. The drug was developed by Takeda and reversibly inhibits the protein proteasome subunit β type-5, which is part of the 20S proteasome complex. Ixazomib citrate (XXIV) is hydrolyzed quickly in vivo to give the biologically active compound ixazomib, which presumably is the corresponding boronic acid variant of XXIV.

Uses

MLN-9708 is a novel proteasome?inhibitor.

Clinical Use

Highly selective and reversible proteasome inhibitor:
Treatment of multiple myeloma in combination with lenalidomide and dexamethasone

Synthesis

The structure of ixazomib citrate is particularly interesting in that it is one of the relatively few marketed drugs which feature a boron atom within its structure (others of note being the oncology medication bortezomib and the antifungal drug tavaborole13). The ostensible scale synthetic approach began with reaction of commercial 2,5-dichlorobenzoyl chloride (188) with glycine in aqueous NaOH to furnish amide 189 in 97% yield as a white crystalline solid. Acid 189 was then coupled with commercially available 1,3,2-benzodioxaborolane 190 in the presence of TBTU and DIPEA in DMF at low temperature to give diamide 191, which was used without purification for the next step. Borane 191 was then deprotected with (2-methylpropyl)boronic acid in methanolic HCl to provide trimer 192 in 74% as a white solid. Finally, boroxin 192 was reacted with citric acid in EtOAc to dissociate the trimer, resulting in ixazomib citrate (XXIV) in 88% yield as a crystalline solid.

MLN9708 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

MLN9708 Suppliers

China 160 China Hong Kong 1 India 5 United States 20 Global 186

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44688
Advantage: 61

Jiangsu Vcare PharmaTech Co., Ltd.

Tel: 13327700685
Fax: +86-25-58744115
Email: sales@vcarepharmatech.com
Country: China
ProdList: 310
Advantage: 61

Jinan Trio PharmaTech Co., Ltd.

Tel: +86 (531) 88811783
Fax: +86 (531) 55696010 QQ 1762738062
Email: sales@trio-pharmatech.com (International market)
Country: China
ProdList: 1856
Advantage: 62

ChemCell Biomedicine Co.,Ltd.

Tel: 020-13556033878 2965585218 13556033878
Fax: 0086-0757-85406358
Email: chemcell@hotmail.com
Country: China
ProdList: 369
Advantage: 52

Shandong Xiya Chemical Co., Ltd

Tel: 4009903999 13355009207
Fax: 0539-6365991
Email: 3007715519@qq.com
Country: China
ProdList: 18738
Advantage: 57

Spectrum Chemical Manufacturing Corp.

Tel: 021-021-021-67601398-809-809-809 15221380277
Fax: 021-57711696
Email: marketing_china@spectrumchemical.com
Country: China
ProdList: 9658
Advantage: 60

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4727
Advantage: 58

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

NCE Biomedical Co.,Ltd.

Tel: 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
Fax: +86-27-87599188
Country: China
ProdList: 1493
Advantage: 55

More

Less

View Lastest Price from MLN9708 manufacturers

Career Henan Chemical Co

Product: MLN9708 1201902-80-8
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-20

1201902-80-8, MLN9708Related Search:

Pevonedistat MLN-4760 MLN-8237 Ixazomib Impurity 1 Ixazomib citrate (USAN) Acetamide, 2-amino-N-[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]- NS-398 Acid resistant proteinase CANGRELOR Azilsartan Tigecycline Pazopanib Boric acid Bortezomib (R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid Oprozomib CEP-18770 ABT 263

4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid

MLN9708

MLN9708,MLN-9708,MLN 9708

4-Carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-acetic acid

4-Carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-acetic acid MLN9708

Ixazomib Citrate

4-(carboxymethyl)-2-(1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid

MLN 9708 - Ixazomib citrate

CS-1830

MLN9708;MLN-9708

4-(Carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dio

MLN 9708 analog

MLN-9708 analog

MLN9708, 98%, 20S proteasome inhibitor

1,3,2-Dioxaborinane-4-acetic acid, 4-carboxy-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-

Ninlaro)

Esazomide citrate

Ixazomib Citrate (MLN9708) Analogue

1201902-80-8

C20H23BCl2N2O9

Inhibitors

Inhibitor

Apis