Quinoline-5-carboxaldehyde
- Product Name
- Quinoline-5-carboxaldehyde
- CAS No.
- 22934-41-4
- Chemical Name
- Quinoline-5-carboxaldehyde
- Synonyms
- 5-Formylquinoline;AKOS BBS-00005336;CHEMBRDG-BB 4300479;RARECHEM AK ML 0025;5-Quinolinecarbaldehyde;QUINOLINE-5-CARBALDEHYDE;5-QUINOLINECARBOXALDEHYDE;QUINOLINE-5-CARBOXALDEHYDE;Quinoline-5-carbaldehyde(QUC);Quinoline-5-carboxaldehyde, 97+%
- CBNumber
- CB3323737
- Molecular Formula
- C10H7NO
- Formula Weight
- 157.17
- MOL File
- 22934-41-4.mol
Quinoline-5-carboxaldehyde Property
- Melting point:
- 95-96°C
- Boiling point:
- 314.3±15.0 °C(Predicted)
- Density
- 1.223±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 3.94±0.12(Predicted)
- Appearance
- Yellow to brown Solid
- Water Solubility
- Slightly soluble in water.
- Sensitive
- Air Sensitive
- BRN
- 113095
- CAS DataBase Reference
- 22934-41-4(CAS DataBase Reference)
Safety
- Risk Statements
- 36/37/38-43
- Safety Statements
- 26-36/37/39-36/37
- HazardClass
- IRRITANT
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- Q990025
- Product name
- Quinoline-5-carbaldehyde
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- BP-20325
- Product name
- QUINOLINE-5-CARBALDEHYDE
- Purity
- 97%
- Packaging
- 1g
- Price
- $186
- Updated
- 2021/12/16
- Product number
- 054396
- Product name
- Quinoline-5-carbaldehyde
- Packaging
- 500mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- CHM0999338
- Product name
- 5-FORMYLQUINOLINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.94
- Updated
- 2021/12/16
- Product number
- 4H15-1-30
- Product name
- Quinoline-5-carboxaldehyde
- Packaging
- 5G
- Price
- $568
- Updated
- 2021/12/16
Quinoline-5-carboxaldehyde Chemical Properties,Usage,Production
Uses
Quinoline-5-carboxaldehyde is used as a precursor in the preparation of pharmaceuticals.
Synthesis
4964-71-0
68-12-2
22934-41-4
General method: n-Butyllithium (2.5 M hexane solution, 300 μL, 0.72 mmol) was added slowly and dropwise to a solution of anhydrous THF (1.5 mL) of 5-bromoquinoline (100 mg, 0.48 mmol) at -78°C. The reaction solution turned red immediately. The reaction solution immediately turned red, followed by the addition of N,N-dimethylformamide (192 μL, 2.49 mmol). After maintaining the reaction temperature at -78 °C with stirring for 10 min, the reaction was quenched with deionized water (6 mL). The reaction mixture was poured into saturated aqueous sodium bicarbonate solution (10 mL) and extracted with ethyl acetate (3 × 10 mL). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: n-hexane solution of 10% ethyl acetate) to give 5-quinolinecarboxaldehyde as a yellow solid in 53% yield.
References
[1] European Journal of Medicinal Chemistry, 2019, p. 290 - 320
Quinoline-5-carboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Quinoline-5-carboxaldehyde manufacturers
- Product
- Quinoline-5-carboxaldehyde 22934-41-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-23
- Product
- Quinoline-5-carboxaldehyde 22934-41-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-26