ChemicalBook > CAS DataBase List > LUCIGENIN

LUCIGENIN

Product Name
LUCIGENIN
CAS No.
2315-97-1
Chemical Name
LUCIGENIN
Synonyms
L-6868;LUCIGENIN;NSC-151912;Lucigenine;Lucigenin Nitrate;Lucigenin, HPLC 99%;LUCIGENIN USP/EP/BP;9,9'-Bi(10-methylacridinium);9,9'-Bi[10-methylacridinium];BIS(N-METHYLACRIDINIUM) NITRATE
CBNumber
CB3325847
Molecular Formula
C28H22N4O6
Formula Weight
510.5
MOL File
2315-97-1.mol
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LUCIGENIN Property

Melting point:
250°C
solubility 
acetic acid: soluble10mg/mL
form 
powder
color 
Yellow powder with orange to brown cast
λmax
455nm
BRN 
3901768
Biological Applications
Chloride indicator; diagnosis of hemostatic disorders; detecting bacteria,nucleicacids,proteins,pathogens; identifying respiratory infections; generating and detecting reactive oxygen species; chemiluminescent indicator
InChI
InChI=1S/C28H22N2.2NO3/c1-29-23-15-7-3-11-19(23)27(20-12-4-8-16-24(20)29)28-21-13-5-9-17-25(21)30(2)26-18-10-6-14-22(26)28;2*2-1(3)4/h3-18H,1-2H3;;/q+2;2*-1
InChIKey
KNJDBYZZKAZQNG-UHFFFAOYSA-N
SMILES
C1(=C2C=CC=CC2=[N+](C)C2=CC=CC=C12)C1=C2C=CC=CC2=[N+](C)C2=CC=CC=C12.[N+]([O-])([O-])=O.[N+]([O-])([O-])=O
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Safety

Safety Statements 
24/25
RIDADR 
1479
WGK Germany 
3
HazardClass 
5.1
PackingGroup 
III
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H272May intensify fire; oxidizer

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P220Keep/Store away from clothing/…/combustible materials.

P221Take any precaution to avoid mixing with combustibles/…

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M8010
Product name
N,N′-Dimethyl-9,9′-biacridinium dinitrate
Purity
used as chemiluminescent reagent
Packaging
1g
Price
$403
Updated
2024/03/01
Sigma-Aldrich
Product number
M8010
Product name
N,N′-Dimethyl-9,9′-biacridinium dinitrate
Purity
used as chemiluminescent reagent
Packaging
5g
Price
$1300
Updated
2024/03/01
TCI Chemical
Product number
B1203
Product name
10,10'-Dimethyl-9,9'-biacridinium Dinitrate [for Chemiluminescence Research]
Purity
>97.0%(HPLC)
Packaging
1g
Price
$170
Updated
2024/03/01
TCI Chemical
Product number
B1203
Product name
10,10'-Dimethyl-9,9'-biacridinium Dinitrate [for Chemiluminescence Research]
Purity
>97.0%(HPLC)
Packaging
5g
Price
$511
Updated
2024/03/01
Cayman Chemical
Product number
14872
Product name
Lucigenin
Purity
≥95%
Packaging
50mg
Price
$32
Updated
2024/03/01
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LUCIGENIN Chemical Properties,Usage,Production

Description

Lucigenin is a chemiluminescent probe used to detect superoxide production and the presence of chloride. It can be used to detect superoxide production by enzymatic and cellular sources. It is a sensitive method that has been applied to the monitoring of superoxide production from xanthine oxidase, microsomal NADPH cytochrome reductase, and NADPH oxidases of phagocytes, endothelial cells, fibroblasts, and smooth muscle cells of blood vessel walls. However, it produces similar chemiluminescence signals in isolated aortic and cardiac tissues from wild-type and Nox1-Nox2-Nox4 triple knockout mice, suggesting that it is not selective for NADPH-based ROS production. It also reacts with hydrogen peroxide without generating free radical intermediates and has been used to detect lipid hydroperoxide in oils. Lucigenin is also used as a fluorescent chloride-sensitive indicator, with its fluorescence being quenched by chloride (ex/em = 455/505 nm, respectively). Lucigenin fluorescence is insensitive to phosphate, sulfate, and nitrate.

Chemical Properties

Dark yellow powder

Uses

Lucigenine, is used as chemiluminescence. It exhibits a bluish-green fluorescence. Dyes and metabolites.

Uses

Chemiluminescent probe for the detection of peroxides in biological systems.

Mechanism of action

In the case of lucigenin it is first reduced to a cation radical. Then it reacts in its univalently reduced form with ROS to produce dioxetane, which breaks down to generate photons. These probes cannot measure the individual free radicals but measure global ROS levels in the sample. Luminescence signals are expressed in relative light units (RLU), a direct measure of free radicals produced.

LUCIGENIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from LUCIGENIN manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
N,N'-Dimethyl-9,9'-bisacridinium nitrate 2315-97-1
Price
US $0.00/g
Min. Order
5g
Purity
>99.00%
Supply Ability
5g
Release date
2024-03-30
Career Henan Chemical Co
Product
LUCIGENIN 2315-97-1
Price
US $1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
100KG
Release date
2018-12-24

2315-97-1, LUCIGENINRelated Search:

N,N'-Ethylenebis(stearamide) (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride N,N-Dimethylaniline N-Methylaniline N,N-Dimethylpropionamide Isoxazole Pyocyanine LUCIFER YELLOW VS DILITHIUM SALT LUCIFER YELLOW CH DILITHIUM SALT 3,7-DIHYDRO-6-[4-[2-[N'-(5-FLUORESCEINYL)THIOUREIDO]ETHOXY]PHENYL]-2-METHYLIMIDAZO[1,2-A]PYRAZIN-3-ONE LUCIGENIN(RG) LUCIGENIN(REAGENT / STANDARD GRADE) Lucigenin [Bis-N-methylacridinium nitrate] *UltraPure Grade* LUCIGENIN [BIS-N-METHYLACRIDINIUM NITRATE]

  • lucigenin or N,N′-dimethyl-9,9′-biacridinium dinitrate
  • L-6868
  • NSC-151912
  • 9,9'-BIS(N-METHYLACRIDINIUM NITRATE)
  • LUCIGENIN
  • 10,10'-Dimethyl-9,9'-biacridinium Dinitrate [for Chemiluminescence Research]
  • BIS(N-METHYLACRIDINIUM) DINITRATE
  • BIS(N-METHYLACRIDINIUM) NITRATE
  • N,N'-DIMETHYL-9,9'-BIACRIDINIUM DINITRATE
  • N,N'-DIMETHYL-9,9'-BIACRIDINIUM NITRATE
  • N,N'-DIMETHYLBISACRIDINIUM DINITRATE
  • 10,10’-dimethyl-9,9’-biacridinium
  • N,N-dimethyl-9,9-bisacridinium nitrate
  • N,N'-DIMETHYL-9,9'-BIACRIDINIUM-
  • BIS-N-METHYLACRIDINIUM NITRATE 97%
  • Lucigenin, HPLC 99%
  • BIS(N-METHYLACRIDINUIM) DINATRATE
  • 9,9μ-Bis(N-methylacridinium nitrate), Lucigenin
  • 10,10'-Dimethyl-9,9'-biacridine-10,10'-diium·2nitrate
  • Lucigenine
  • 10,10'-Dimethyl-9,9'-biacridine-10,10'-diium
  • 9,9'-Bi(10-methylacridinium)
  • 9,9'-Bi[10-methylacridinium]
  • 10,100-dimethyl-9,90-biacridinium Dinitrate
  • N,n0-dimethyl-9,90-biacridinium Dinitrate
  • 9,90biacridinium, 10,100-dimethyl-, Dinitrate
  • 9,90-bis(nmethylacridinium Nitrate)
  • Lucigenin Nitrate
  • 10-methyl-9-(10-methylacridin-10-ium-9-yl)acridin-10-ium,dinitrate
  • Bis(N-methylacridinium) Nitrate [for Chemiluminescence Research]
  • N,N'-Dimethyl-9,9'-biacridinium dinitrate, ≥97.0%
  • Bis(N-methylacridinium) Nitrate [for Chemiluminescence Research]&gt
  • N,N'-Dimethyl-9,9'-biacridinium dinitrat
  • LUCIGENIN USP/EP/BP
  • 9,9'-Biacridinium, 10,10'-dimethyl-, nitrate (1:2)
  • N,N′-Dimethyl-9,9′-biacridinium dinitrate, ≥98%
  • N,N'-Dimethyl-9,9'-biacridinium dinitrate
  • 10,10'-Dimethyl-9,9'-biacridinium Dinitrate
  • 9,9'-Biacridinium, 10,10'-dimethyl-, nitrate (1:2)
  • Lucigenin, Superoxide anion radical chemiluminescent probe
  • 2315-97-1
  • C28H22N22NO3
  • C28H22N4O6
  • C28H222N2O3
  • BioChemical
  • Biochemicals and Reagents
  • Detection
  • Fluorescent Probes, Labels, Particles and Stains
  • Acridinium (Chemiluminescence)
  • Chemiluminescence
  • Miscellaneous Natural Products
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Acridinium (Chemiluminescence)
  • Acridine
  • Analytical Chemistry
  • Chemiluminescence