ChemicalBook > CAS DataBase List > TAMARIXETIN

TAMARIXETIN

Product Name: TAMARIXETIN
CAS No.: 603-61-2
Chemical Name: TAMARIXETIN
Synonyms: Aids098167;amarixetin;Chiosmethin;TAMARIXETIN;Aids-098167;tamaraxetin;TAMARIEXETIN;4’-methylquercetin;4'-Methylquercetin;4’-methoxyquercetin
CBNumber: CB3328499
Molecular Formula: C16H12O7
Formula Weight: 316.26
MOL File: 603-61-2.mol

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TAMARIXETIN Property

Melting point:: 265-268°C
Boiling point:: 601.8±55.0 °C(Predicted)
Density: 1.634±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: Slightly Soluble; Methanol: Slightly Soluble
form: A solid
pka: 6.31±0.40(Predicted)
color: Yellow to brown
LogP: 2.420 (est)

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Safety

Risk Statements: 22
Safety Statements: 22-45

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL85778
Product name: Tamarixetin
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $734
Updated: 2025/07/31

Cayman Chemical

Product number: 22406
Product name: 4'-O-methyl Quercetin
Purity: ≥98%
Packaging: 500μg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 22406
Product name: 4'-O-methyl Quercetin
Purity: ≥98%
Packaging: 1mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 22406
Product name: 4'-O-methyl Quercetin
Purity: ≥98%
Packaging: 5mg
Price: $294
Updated: 2024/03/01

Cayman Chemical

Product number: 22406
Product name: 4'-O-methyl Quercetin
Purity: ≥98%
Packaging: 10mg
Price: $539
Updated: 2024/03/01

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TAMARIXETIN Chemical Properties,Usage,Production

Description

4''-O-methyl Quercetin is a flavonoid isolated from C. ordata with anticancer and antiplasmodial activity. 4''-O-methyl Quercetin is a major metabolite of quercetin (Item No. 10005169) that inhibits the viability of HL-60, U937, MOLT-3, Raji, K562, MCF-7, SK-MEL-1, and A549 human tumor cell lines with IC₅₀ values ranging from 5.5-24.1 μM. It induces G₂-M arrest and inhibits tubulin polymerization in vitro in a dose-dependent manner. 4''-O-methyl Quercetin inhibits breast cancer resistance protein (BCRP/ABCG2; IC₅₀ = 40 nM in a vesicular transport assay) with no cellular toxicity indicating potential for use in overcoming multidrug resistance in chemotherapy. 4''-O-methyl Quercetin also reduces in vitro proliferation of chloroquine-resistant P. falciparum (IC₅₀ = 4.8 μM) and suppresses infection in mice (65-81% suppression at 2.5-5 mg/kg dose).

Uses

A major metabolite of the flavanoid Quercetin (Q509500) with antioxidant properties. It helps to protect H9c2 cardiomyoblasts against H2O2-induced oxidative stress via the modulation of PI3K/Akt and ERK1/2 signaling pathways.

Definition

ChEBI: A monomethoxyflavone that is quercetin methylated at position O-4'. Isolated from Cyperus teneriffae.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

in vivo

Tamarixetin (0.2% feed management; 6 weeks) improves the myocardial hypertrophy model ^[2].
Tamarixetin (intraperitoneal injection; 1 mg/kg; single dose) has better anti-inflammatory properties, which is related to the increase of the immune cell population secreting IL-10 in mouse models of bacterial septicemia^[3].

Animal Model:	Transverse aortic constriction (TAC) mouse model^[2]
Dosage:	0.2%
Administration:	Feed management; 6 weeks
Result:	Alleviated pressure?overload?induced cardiac hypertrophy in mice. Attenuated cardiac fibrosis and apoptosis in pressure?overloaded hearts. Suppressed oxidative stress. Negatively regulated NFAT nuclear translocation level. Was able to the down-regulate the activation of PI3K/AKT signaling pathway in the heart after pressure overload.

References

[1] FABIO NICOLINI. Induction of G2/M phase arrest and apoptosis by the flavonoid tamarixetin on human leukemia cells.[J]. Molecular Carcinogenesis, 2014, 53 12: 939-950. DOI: 10.1002/mc.22055
[2] KEE W. TAN . Identification of novel dietary phytochemicals inhibiting the efflux transporter breast cancer resistance protein (BCRP/ABCG2)[J]. Food Chemistry, 2013, 138 4: Pages 2267-2274. DOI: 10.1016/j.foodchem.2012.12.021
[3] I C EZENYI. Antiplasmodial activity-aided isolation and identification of quercetin-4’-methyl ether in Chromolaena odorata leaf fraction with high activity against chloroquine-resistant Plasmodium falciparum.[J]. Parasitology Research, 2014, 113 12: 4415-4422. DOI: 10.1007/s00436-014-4119-y

TAMARIXETIN Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from TAMARIXETIN manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Tamarixetin 603-61-2
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-05-07

Career Henan Chemical Co

Product: TAMARIXETIN 603-61-2
Price: US $1.00/KG
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-24

603-61-2, TAMARIXETINRelated Search:

SPIRAEOSIDE ARTEMETIN 3,7,3',4'-TETRAMETHYLGOSSYPETIN TAMARIXETIN QUERCETIN-3,7,3',4'-TETRAMETHYL ETHER CASTICIN 3,5,7-TRIHYDROXY-3',4',5'-TRIMETHOXYFLAVONE 3,4'-DIMETHOXY-3',5,7-TRIHYDROXYFLAVONE QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER Fisetin 4'-METHOXYFLAVONE QUERCETIN-7,4'-DIGLUCOSIDE 4',7-DIMETHOXY-3,3',5-TRIHYDROXYFLAVONE Tamarixetin 3-methylether 3,3',4',5,6,7,8-heptamethoxyflavone 3'-BENZYLOXY-5,7-DIHYDROXY-3,4'-DIMETHOXYFLAVONE QUERCETINPENTAACETATE Ombuoside

3,3',5,7 TETRAHYDROXY-4'-METHOXYFLAVONE

TAMARIXETIN

QUERCETIN-4'-METHYL ETHER

3,3’,5,7-tetrahydroxy-4’-methoxy-flavon

QUERCETIN-4''-METHYL ETHER hplc

3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

Chiosmethin

4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-

Aids098167

Aids-098167

4'-METHOXY-3,3',5,7-TETRAHYDROXYFLAVONE

4'-METHOXY-3,5,7,3'-TETRAHYDROFLAVONE

3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one

3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4h-1-benzopyran-4-on

4’-methoxy-3,3’,5,7-tetrahydroxy-flavon

4’-methoxyquercetin

4’-methylquercetin

4’-o-methylquercetin

tamaraxetin

3,5,7-trihydroxy-2-(3-hydroxy-4-methoxy-phenyl)chroman-4-one

TAMARIEXETIN

TAMARIXETIN WITH HPLC

3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone

amarixetin

TamarixetinQ: What is Tamarixetin Q: What is the CAS Number of Tamarixetin Q: What is the storage condition of Tamarixetin Q: What are the applications of Tamarixetin

Tamarixetin（3,3',5,7-Tetrahydroxy-4'-Methoxyflavone）

3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one

3,3',5,7-Tetrahydroxy 4'-methoxyflavone

4'-Methylquercetin

Quercetin 4'-methyl ether

Tamarixetin, 10 mM in DMSO

4′-O-Methyl Quercetin, CAS 603-61-2

603-61-2

C16H12O7

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Flavanols