ChemicalBook > CAS DataBase List > Bis(cyclohexanone)oxaldihydrazone

Bis(cyclohexanone)oxaldihydrazone

Product Name: Bis(cyclohexanone)oxaldihydrazone
CAS No.: 370-81-0
Chemical Name: Bis(cyclohexanone)oxaldihydrazone
Synonyms: CUPRIZON;CUPRIZONE;Cuprizane;CUPRIZON 1;CUPRIZON I;CUPRIZONE I;CUPFERAZONE;Cuprizonl,98%;oxaldihydrazone;Oxalic acid bis
CBNumber: CB3334186
Molecular Formula: C14H22N4O2
Formula Weight: 278.35
MOL File: 370-81-0.mol

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Bis(cyclohexanone)oxaldihydrazone Property

Melting point:: 210-214 °C(lit.)
Boiling point:: 421.17°C (rough estimate)
Density: 1.0823 (rough estimate)
bulk density: 150kg/m3
refractive index: 1.6200 (estimate)
storage temp.: 2-8°C
solubility: acetic acid: 50mg/mL, colorless to very faintly brown
form: Powder
pka: 10.78±0.20(Predicted)
color: White
Water Solubility: Soluble in alcohol. Insoluble in water.
BRN: 2388004
CAS DataBase Reference: 370-81-0(CAS DataBase Reference)
EPA Substance Registry System: Ethanedioic acid, bis(cyclohexylidenehydrazide) (370-81-0)

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Safety

Hazard Codes: Xn
Risk Statements: 21/22
Safety Statements: 24/25-2
WGK Germany: 3
RTECS: RO2520000
TSCA: Yes
HS Code: 29280090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 14690
Product name: Bis(cyclohexanone)oxaldihydrazone
Purity: for spectrophotometric det. of Cu, ≥99.0%
Packaging: 25g
Price: $90.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: 14690
Product name: Bis(cyclohexanone)oxaldihydrazone
Purity: for spectrophotometric det. of Cu, ≥99.0%
Packaging: 100g
Price: $264
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1.01841
Product name: Oxalic acid bis (cyclohexylidene hydrazide)
Purity: GR for analysis (reagent for copper)
Packaging: 25g
Price: $194
Updated: 2022/05/15

TCI Chemical

Product number: B0476
Product name: Bis(cyclohexanone) Oxalyldihydrazone
Purity: >98.0%(T)
Packaging: 1g
Price: $53
Updated: 2025/07/31

TCI Chemical

Product number: B0476
Product name: Bis(cyclohexanone) Oxalyldihydrazone
Purity: >98.0%(T)
Packaging: 25g
Price: $192
Updated: 2025/07/31

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Bis(cyclohexanone)oxaldihydrazone Chemical Properties,Usage,Production

Chemical Properties

white powder

Uses

Bis(cyclohexanone) oxaldihydrazone is used in the quantitative spectroscopic determination of copper. It is also essential for the experimental study of mitochondrial metabolism. It is used to study the human demyelinating diseases such as multiple sclerosis and components of neuroinflammation. Further, it acts as ligand and catalyzes Ullmann-type C-N bond forming reactions in the presence of copper salt.

Definition

ChEBI: Cuprizon is an organooxygen compound and an organonitrogen compound. It is functionally related to an alpha-amino acid.

Biological Activity

Bis(cyclohexanone)oxaldihydrazone (Cuprizone) is a copper chelator. It results in oligodendroglial cell death, thereby leading to demyelination, astrogliosis and microglia activation. Cuprizone is widely used to study mitochondrial dysfunction-associated primary demyelination and remyelination in the corpus callosum.

Safety Profile

Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also OXALATES.

Bis(cyclohexanone)oxaldihydrazone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Bis(cyclohexanone)oxaldihydrazone manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: Bis(cyclohexanone)oxaldihydrazone 370-81-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 20tons
Release date: 2025-09-18

Career Henan Chemical Co

Product: Bis(cyclohexanone)oxaldihydrazone 370-81-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-03-05

Career Henan Chemical Co

Product: Bis(cyclohexanone)oxaldihydrazone 370-81-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPLC
Supply Ability: 10 tons
Release date: 2020-02-14

370-81-0, Bis(cyclohexanone)oxaldihydrazoneRelated Search:

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Bis(cyclohexanone)oxaldihydrazone, 98%, for spectrophotometric det. of Cu

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Bis-Cyclohexanone Oxalyl Dihydrazide 99% AR

370-81-0

C14H22N4O2