1,3-Bis(4,5-dihydro-2-oxazolyl)benzene

Uses

Product Name: 1,3-Bis(4,5-dihydro-2-oxazolyl)benzene
CAS No.: 34052-90-9
Chemical Name: 1,3-Bis(4,5-dihydro-2-oxazolyl)benzene
Synonyms: 1,3-PBO;3-Bis(4;Two oxazoline;1,3-Bisbenzene;1,3-PHENYLENBISOXAZOLINE;bisdihydrooxazolylbenzene;1,3-Phenylene-bis-oxazoline;5-dihydro-2-oxazolyl)benzene;1,3-Bis(4,5-dihydro-2-oxazoL;1,3-Bisdihydrooxazolylbenzene
CBNumber: CB3334267
Molecular Formula: C12H12N2O2
Formula Weight: 216.24
MOL File: 34052-90-9.mol

More

Less

1,3-Bis(4,5-dihydro-2-oxazolyl)benzene Property

Melting point:: 147-151°C
Boiling point:: 403.5±28.0 °C(Predicted)
Density: 1.45
Flash point:: 208°C
storage temp.: Sealed in dry,Room Temperature
Water Solubility: Insoluble in water
form: powder to crystal
pka: 4.78±0.50(Predicted)
color: White to Light yellow to Light red
InChI: InChI=1S/C12H12N2O2/c1-2-9(11-13-4-6-15-11)8-10(3-1)12-14-5-7-16-12/h1-3,8H,4-7H2
InChIKey: HMOZDINWBHMBSQ-UHFFFAOYSA-N
SMILES: C1(C2=NCCO2)=CC=CC(C2=NCCO2)=C1
CAS DataBase Reference: 34052-90-9(CAS DataBase Reference)
EPA Substance Registry System: Oxazole, 2,2'-(1,3-phenylene)bis[4,5-dihydro- (34052-90-9)

More

Less

Safety

Risk Statements: 22
Safety Statements: 22-24/25
HS Code: 2934.99.4400

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: B1511
Product name: 1,3-Bis(4,5-dihydro-2-oxazolyl)benzene
Purity: >98.0%(GC)
Packaging: 25g
Price: $49
Updated: 2025/07/31

TCI Chemical

Product number: B1511
Product name: 1,3-Bis(4,5-dihydro-2-oxazolyl)benzene
Purity: >98.0%(GC)
Packaging: 100g
Price: $81
Updated: 2025/07/31

TCI Chemical

Product number: B1511
Product name: 1,3-Bis(4,5-dihydro-2-oxazolyl)benzene
Purity: >98.0%(GC)
Packaging: 500g
Price: $243
Updated: 2025/07/31

TRC

Product number: D453273
Product name: 1,3-Bis(4,5-dihydrooxazol-2-yl)benzene
Packaging: 5g
Price: $60
Updated: 2021/12/16

Chem-Impex

Product number: 40970
Product name: 1,3-Bis(4,5-dihydro-2-oxazolyl)benzene,≥98%(GC)
Purity: ≥98%(GC)
Packaging: 25G
Price: $45.43
Updated: 2021/12/16

More

Less

1,3-Bis(4,5-dihydro-2-oxazolyl)benzene Chemical Properties,Usage,Production

Uses

Dioxazoline is an important organic reaction intermediate. It is a compound containing a five-membered heterocycle with two carbon, nitrogen, and oxygen atoms and a carbon-nitrogen double bond. Because of its highly reactive chemical properties, it can undergo ring-opening reactions with carboxyl groups, acid anhydrides, amino groups, epoxy groups, thiol groups, phenolic hydroxyl groups, isocyanate groups, etc. at certain temperatures. Therefore, dioxazoline is often used as a chain extender or cross-linking agent for polymers.

Definition

Bisoxazoline is an essential organic reaction intermediate. It is a five-membered heterocyclic compound containing two carbons, nitrogen, oxygen and a carbon-nitrogen double bond. Because of its active chemical properties, it can undergo ring-opening reactions with carboxyl, anhydride, amino, epoxy, thiol, phenolic hydroxyl, isocyanate, etc., at a certain temperature. Therefore, bisoxazoline can often be used as a chain extender or cross-linking agent for polymers.

Synthesis

626-17-5

141-43-5

34052-90-9

GENERAL METHOD: A mixture of isophthalonitrile (0.5 mmol), 2-aminoethanol (0.65 mmol, 0.040 g), Co(NO3)2 (0.02 mmol, 0.036 g), and sulfur (0.05 mmol, 0.0016 g) was stirred for an appropriate period of time at 90 °C, or reacted under microwave radiation (90 °C, 800 W) for the corresponding Time. For the synthesis of monooxazolines, a mixture of isophthalonitrile (0.5 mmol), 2-aminoethanol (0.65 mmol, 0.040 g), Co(NO3)2 (0.02 mmol, 0.036 g) and sulfur (0.05 mmol, 0.0016 g) was stirred for 3 h at 90 °C or reacted under microwave radiation conditions (90 °C, 800 W) for 3 min . For the synthesis of bisoxazoline, isophthalonitrile (0.5 mmol), 2-aminoethanol (2.6 mmol, 0.159 g), Co(NO3)2 (0.02 mmol, 0.036 g), and sulfur (0.05 mmol, 0.0016 g) were stirred for 10 hr at 110 °C or reacted under microwave radiation conditions (110 °C, 800 W) for 8 minutes. After completion of the reaction (monitored by TLC), the reaction mixture was cooled to room temperature, ethyl acetate (6 mL) was added and the catalyst was separated by filtration. After concentration under reduced pressure, the residue was purified by silica gel column chromatography to afford the pure product 1,3-bis(4,5-dihydrooxazol-2-yl)benzene (5a-r).

References

[1] Journal of Organic Chemistry, 2015, vol. 80, # 20, p. 9910 - 9914
[2] Synlett, 2005, # 18, p. 2747 - 2750
[3] Tetrahedron, 2013, vol. 69, # 32, p. 6591 - 6597
[4] Monatshefte fur Chemie, 2009, vol. 140, # 12, p. 1489 - 1494
[5] Journal of the Serbian Chemical Society, 2012, vol. 77, # 9, p. 1181 - 1189,9

1,3-Bis(4,5-dihydro-2-oxazolyl)benzene Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1,3-Bis(4,5-dihydro-2-oxazolyl)benzene Suppliers

Americas 1 Belgium 1 China 187 Czech 1 Europe 1 France 2 Germany 5 India 6 Japan 4 The Netherlands 1 United Kingdom 5 United States 17 Global 231

Record Tech (Shanghai) Co., LTD

Tel: 13761627472
Fax: 86-21-64965863
Email: 183009664@qq.com
Country: China
ProdList: 649
Advantage: 62

Wuhan kamik Technology Co., Ltd

Tel: 18162538168
Email: 201981259@qq.com
Country: China
ProdList: 7743
Advantage: 58

Hubei Changxinsheng Chemical Co., Ltd

Tel: 18971203904
Email: 1601302530@qq.com
Country: China
ProdList: 492
Advantage: 58

Beijing FaMu RuiSi Pharmaceuticals Co.,Ltd

Tel: 18901358086
Fax: 86-010-61252196
Email: pharma_reese@126.com
Country: China
ProdList: 61
Advantage: 57

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
Fax: +86 351 7031519
Email: sales@RHFChem.com
Country: China
ProdList: 2338
Advantage: 56

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

More

Less

View Lastest Price from 1,3-Bis(4,5-dihydro-2-oxazolyl)benzene manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 1,3-Bis(4,5-dihydro-2-oxazolyl)benzene 34052-90-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-10-31

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1,3-Bis(4,5-dihydro-2-oxazolyl)benzene 34052-90-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1,3-Bis(4,5-dihydro-2-oxazolyl)benzene 34052-90-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

34052-90-9, 1,3-Bis(4,5-dihydro-2-oxazolyl)benzeneRelated Search:

Chlorodiphenylphosphine Diphenylsilane Diphenylphosphine Oxazoline Xylene tert-Butylchlorodiphenylsilane Dichlorodiphenylsilane Chlorodimethylphenylsilane Benzene 4-bromo-1-methylpyrazole-3-carboxy acid 5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER 2,5-DIBROMO-3-AMINOPYRIDINE 4,5-Dihydrooxazole, 2-vinyl- 1-methyl-1H-pyrazol-4-amine 1,4-BIS(4,5-DIHYDRO-2-OXAZOLYL)BENZENE 3-METHYL-BENZIMIDIC ACID ETHYL ESTER 1,3-Bis(4,5-dihydro-2-oxazolyl)benzene 1,3-BIS(4,5-DIHYDRO-2-OXAZOLYL)BENZENE=2,2'-(1,3-PHENYLEN)BIS-2-OXAZOLINE

1,3-Bis(2-oxazolidinyl-2-yl)benzene

1,3-Bis(4,5-dihydrooxazole-2-yl)benzene

3-Bis(4,5-dihydro-2-oxazolyl)benzene

4,5-DIHYDRO-2-(3-(4,5-DIHYDROOXAZOL-2-YL)PHENYL)OXAZOLE

3-Bis(4

5-dihydro-2-oxazolyl)benzene

Oxazole,2,2'-(1,3-phenylene)bis[4,5-dihydro-

1,3-Bisbenzene

Two oxazoline

2-[3-(4,5-dihydrooxazol-2-yl)phenyl]-4,5-dihydrooxazole

1,3-Bis(4,5-dihydrooxazol-2-yl)benzene

bisdihydrooxazolylbenzene

2,2′-(1,3-Phenyl)bis(2-oxazolin)

2'-(1,3-Phenylene)bis-2-oxazoline

1,3-BIS(4,5-DIHYDRO-2-OXAZOLYL)BENZENE 98+%

2,2'-(1,3-phenylene)bis-2-oxazolin

2,2'-(1,3-PHENYLENE)BIS(2-OXAZOLINE)

1,3-Bisdihydrooxazolylbenzene

1,3-Phenylene-bis-oxazoline

1,3-PHENYLENBISOXAZOLINE

1,3-PBO

1,3-BIS(2-OXAZOLIN-2-YL)BENZENE

1,3-BIS(4,5-DIHYDRO-2-OXAZOLYL)BENZENE

2,2’-(1,3-phenylene)bis(4,5-dihydro)-Oxazole

1,3-Bis(4,5-dihydro-2-oxazolyl)benzene &gt

1,3-Bis(4,5-dihydro-2-oxazoL

1,3-di-(2-Oxazolin-2-yl)benzene

TIANFUCHEM--34052-90-9---1,3-Bis(4,5-dihydro-2-oxazolyl)benzene

1,3 –PHENYLENE-BIS-OXAZOLINE(PBO)

2,2'-(1,3-phenylene)bis-2-oxazoline

2,2'-(1,3-phenylene)bis-2-oxazoline(1,3-Bis(4,5-dihydro-2-oxazolyl)benzene)

2,2'-(1,3-phenylene)bis(4,5-dihydro-1,3-oxazole)

34052-90-9