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Schisandrin

Product Name
Schisandrin
CAS No.
7432-28-2
Chemical Name
Schisandrin
Synonyms
SCHISANDROL A;SCHIZANDRIN;SCHIZANDROL A;Schisandrol;SCHIZANDROL;12aR)-;schizandra;SCHISANDRIN;Schisadrol A;Schisandrinum
CBNumber
CB3334838
Molecular Formula
C24H32O7
Formula Weight
432.51
MOL File
7432-28-2.mol
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Schisandrin Property

Melting point:
128.5°C
Boiling point:
466.17°C (rough estimate)
Density 
1.1480 (rough estimate)
refractive index 
1.5800 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: ≥13mg/mL
pka
14.58±0.40(Predicted)
form 
powder
color 
white to beige
optical activity
[α]/D 75 to 95°, c = 1 in methanol
InChI
InChI=1S/C24H32O7/c1-13-9-14-10-16(26-3)20(28-5)22(30-7)18(14)19-15(12-24(13,2)25)11-17(27-4)21(29-6)23(19)31-8/h10-11,13,25H,9,12H2,1-8H3
InChIKey
YEFOAORQXAOVJQ-UHFFFAOYSA-N
SMILES
O(C1C(=C(OC)C=C2CC(O)(C)C(C)CC3C=C(OC)C(OC)=C(OC)C=3C=12)OC)C
LogP
3.153 (est)
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-50/53
Safety Statements 
60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
HS Code 
29093090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0054
Product name
Schizandrin
Purity
≥98% (HPLC)
Packaging
10mg
Price
$80.18
Updated
2025/07/31
Sigma-Aldrich
Product number
Y0001818
Product name
Schizandrin
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
15 mg
Price
$153
Updated
2025/07/31
Sigma-Aldrich
Product number
PHL89885
Product name
Schisandrol A
Purity
phyproof? Reference Substance
Packaging
10MG
Price
$597
Updated
2025/07/31
Sigma-Aldrich
Product number
1609895
Product name
Schisandrin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
15mg
Price
$321
Updated
2025/07/31
Cayman Chemical
Product number
27211
Product name
Schizandrin
Packaging
10mg
Price
$57
Updated
2024/03/01
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Schisandrin Chemical Properties,Usage,Production

Description

Schizandrin is a dibenzocyclooctadiene lignan and a major component of S. chinensis and has diverse biological activities. It induces cell cycle arrest at the G0/G1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells when used at a concentration of 100 μM. Schizandrin (10 and 100 μM) prevents glutamate-induced cytotoxicity, inhibits production of nitric oxide (NO) and reactive oxygen species (ROS), and preserves the mitochondrial membrane potential in isolated rat cortical cells. It reduces apoptosis induced by cisplatin in HK-2 human kidney cells. In vivo, schizandrin (1 and 10 mg/kg, p.o.) reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats. It enhances oxotremorine-induced tremors in mice. Schizandrin (10 mg/kg) reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy.

Chemical Properties

White crystals soluble in DMSO, slightly soluble in methanol and ethanol. Derived from the dried mature fruit of Schisandra chinensis (Turcz.) Baill., a plant of the Magnoliaceae family.

Uses

Schizandrin may be used in oxidative stress-related cell signaling studies.

Application

Schizandrin is a natural compound that belongs to the group of schisandrins. Schizandrins are a class of compounds with biochemical properties and biological activities, such as anti-inflammatory, antioxidant, and anti-cancer effects. This compound has been shown to have pro-apoptotic properties in a model system. It has also demonstrated the ability to inhibit influenza A virus replication in vitro and protect mice against Listeria monocytogenes infection. It can be used as an inhibitor of gsh-px activity in myocardial infarcts.

Definition

ChEBI: Schizandrin is a tannin.

Biochem/physiol Actions

Schizandrin is a natural product with several biological properties involved with antioxidant and anti-inflammatory activities. It reduces the formation of ROS, inhibits the mitochondrial pathway of the apoptotic process and oxidative stress. Schizandrin has been reported to have hepatoprotective, antitumor, antiviral, and antiamnesic effects, and has neuroprotective activity against glutamate induced neurotoxicity.

References

[1] SUN-JACK KIM. Growth inhibition and cell cycle arrest in the G0/G1 by schizandrin, a dibenzocyclooctadiene lignan isolated from Schisandra chinensis, on T47D human breast cancer cells.[J]. Phytotherapy Research, 2010, 24 2: 193-197. DOI: 10.1002/ptr.2907
[2] HAO-YUAN CHENG . Schizandrin Protects Primary Cultures of Rat Cortical Cells From Glutamate-Induced Excitotoxicity[J]. Journal of pharmacological sciences, 2008, 107 1: Pages 21-31. DOI: 10.1254/jphs.fp0072394
[3] VALéRIAN BUNEL. Protective effects of schizandrin and schizandrin B towards cisplatin nephrotoxicity in vitro.[J]. Journal of applied toxicology?: JAT, 2014: 1311-1319. DOI: 10.1002/jat.2951
[4] NOBUAKI EGASHIRA. Schizandrin reverses memory impairment in rats.[J]. Phytotherapy Research, 2008, 22 1: 49-52. DOI: 10.1002/ptr.2258
[5] NA‐RA HAN. Schisandra chinensis and Its Main Constituent Schizandrin Attenuate Allergic Reactions by Down-Regulating Caspase-1 in Ovalbumin-Sensitized Mice.[J]. The American journal of Chinese medicine, 2017, 45 1 1: 159-172. DOI: 10.1142/s0192415x17500112

Schisandrin Preparation Products And Raw materials

Raw materials

Preparation Products

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Schisandrin Suppliers

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View Lastest Price from Schisandrin manufacturers

Lianyungang Kaiyu Environmental Tech Co., Ltd.
Product
Schizandrin 7432-28-2
Price
US $1200.00-1100.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
1000T/M
Release date
2025-10-21
Wuhan JiyunZen Tech Co., Ltd.
Product
Schisandrin 7432-28-2
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-05-08
Wuhan JiyunZen Tech Co., Ltd.
Product
Schisandrin 7432-28-2
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-05-08

7432-28-2, SchisandrinRelated Search:

Dimethyl fumarate ETHANE Dimethyl sulfoxide Dimethyl phthalate S(-)-SCHISANDRIN,S(-) SCHISANDRIN B,SCHISANDRIN B,SCHISANDRIN, GAMMA-,GAMMA-SCHISANDRIN,SCHISANDRIN(SCHISANDROL A)(P) 4-Methoxybenzyl alcohol Schisandrin A N,N-Dimethylformamide Dimethyl carbonate Dimethyl sebacate Dimethyl ether Nortropine Gomisin A Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-1-ol, 5,6,7,8-tetrahydro-2, 3,13-trimethoxy-6,7-dimethyl-, stereoisomer 2-BUTENOIC ACID, 2-METHYL-, (5S,6S,7S,13AS)-5,6,7,13A-TETRAHYDRO-6-HYDROXY-1,2,3,13-TETRAMETHOXY-6,7-DIMETHYLBENZO[3,4]CYCLOOCTA[1,2-F][1,3]BENZODIOXOL-5-YL ESTER, (2Z)- schisanhenol WUWEIZISU C Schisantherin A

  • SCHIZANDROL
  • Schisandrin,Schizandrin
  • chisandrin 5,6,7,8-Tetrahydro-6,7-dimethyl-1,2 3,10,11,12-hexamethoxydibenzo[a,c]cycloocten-6-ol
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  • Schisadrol A
  • dibenzo(a,c)cycloocten-6-ol,5,6,7,8-tetrahydro-6,7-dimethyl-1,23,10,11,12-hex
  • schizandra
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  • Schisandrin (Schizandrol
  • Dibenzo[a,c]cycloocten-6-ol, 5,6,7,8-tetrahydro-1,2,3,10,11,12-hexamethoxy-6,7-dimethyl-, (6S,7S,12aR)-
  • hot selling Schisandra Berries P.E
  • DeoxyschizandrinSchisandra chinensis extract
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  • Schisandrin methyl
  • Schisandrol A structure
  • Abametapir Impurity 29
  • Schisandrin, 10 mM in DMSO
  • Schisandrinum
  • Extractum Schisandrae chinensis
  • Schisandra schisandrins
  • 7432-28-2
  • C24H32O7
  • Inhibitors
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
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  • Miscellaneous Natural Products
  • Natural Plant Extract
  • chemical reagent
  • pharmaceutical intermediate