GW-870086

Product Name: GW-870086
CAS No.: 827319-43-7
Chemical Name: GW-870086
Synonyms: AXR-159;CPD1550;GW870086;GW-870086, 10 mM in DMSO;GW-870086,Glucocorticoid Receptor,GW 870086,Inhibitor,inhibit,GW870086;Androsta-1,4-diene-17-carboxylic acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-[[(2,2,3,3-tetramethylcyclopropyl)carbonyl]oxy]-, cyanomethyl ester, (6α,11β,16α,17α)-;cyanomethyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2,2,3,3-tetramethylcyclopropanecarbonyl)oxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carboxylate;cyanomethyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-((2,2,3,3-tetramethylcyclopropane-1-carbonyl)oxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cycl openta[a]phenanthrene-17-carboxylate
CBNumber: CB33367974
Molecular Formula: C31H39F2NO6
Formula Weight: 559.6412664
MOL File: 827319-43-7.mol

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GW-870086 Property

Boiling point:: 630.6±55.0 °C(Predicted)
Density: 1.28±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 12.55±0.70(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0028661
Product name: 6,9-DIFLUORO-11-HYDROXY-16-METHYL-3-OXO-17-(((2,2,3,3-TETRAMETHYLCYCLOPROPYL)CARBONYL)OXY)- CYANOMETHYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $458.04
Updated: 2021/12/16

DC Chemicals

Product number: DC33133
Product name: GW-870086
Packaging: 1g
Price: $1900
Updated: 2021/12/16

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GW-870086 Chemical Properties,Usage,Production

Uses

GW-870086 is a potent anti-inflammatory agent, acting as a glucocorticoid receptor agonist, with a pIC50 of 10.1 in A549 cells expressing NF-κB.

References

[1] Uings IJ, et al. Discovery of GW870086: a potent anti-inflammatory steroid with a unique pharmacological profile. Br J Pharmacol. 2013 Jul;169(6):1389-403. DOI:10.1111/bph.12232
[2] Stamer WD, et al. Unique response profile of trabecular meshwork cells to the novel selective glucocorticoid receptor agonist, GW870086X. Invest Ophthalmol Vis Sci. 2013 Mar 1;54(3):2100-7. DOI:10.1167/iovs.12-11298

GW-870086 Preparation Products And Raw materials

Raw materials

Preparation Products

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GW-870086 Suppliers

China 28 United States 3 Global 31

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827319-43-7, GW-870086Related Search:

2137975-08-5 NDI-010976 CU-CPT-8m CU-CPT-9a

CPD1550

GW870086

cyanomethyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2,2,3,3-tetramethylcyclopropanecarbonyl)oxy-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthrene-17-carboxylate

cyanomethyl (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-((2,2,3,3-tetramethylcyclopropane-1-carbonyl)oxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cycl openta[a]phenanthrene-17-carboxylate

GW-870086,Glucocorticoid Receptor,GW 870086,Inhibitor,inhibit,GW870086

Androsta-1,4-diene-17-carboxylic acid, 6,9-difluoro-11-hydroxy-16-methyl-3-oxo-17-[[(2,2,3,3-tetramethylcyclopropyl)carbonyl]oxy]-, cyanomethyl ester, (6α,11β,16α,17α)-

AXR-159

GW-870086, 10 mM in DMSO

827319-43-7