ChemicalBook > CAS DataBase List > CU-CPT-9a

CU-CPT-9a

Product Name
CU-CPT-9a
CAS No.
2162962-69-6
Chemical Name
CU-CPT-9a
Synonyms
CPD1577;CU-CPT-9a;TLR8 inhibitor;cas 2162962-69-6;TLR8-specific antagonist 1;4-(4-hydroxy-3-methylphenyl)quinolin-7-ol;CU-CPT-9A;CAS 2162962-69-6;TLR8 INHIBITOR;2-Methyl-4-(7-hydroxy-4-quinolinyl)phenol;7-Quinolinol, 4-(4-hydroxy-3-methylphenyl)-;inhibit,Toll-like Receptor (TLR),CU-CPT9b,Inhibitor,CUCPT9b,CU CPT9b
CBNumber
CB33369600
Molecular Formula
C16H13NO2
Formula Weight
251.28
MOL File
2162962-69-6.mol
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CU-CPT-9a Property

Boiling point:
452.6±45.0 °C(Predicted)
Density 
1.287±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml
form 
A crystalline solid
pka
8.46±0.20(Predicted)
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28723
Product name
CU-CPT9b
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
28723
Product name
CU-CPT9b
Packaging
25mg
Price
$494
Updated
2024/03/01
Cayman Chemical
Product number
28723
Product name
CU-CPT9b
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
28723
Product name
CU-CPT9b
Packaging
10mg
Price
$214
Updated
2024/03/01
Tocris
Product number
6479
Product name
CUCPT9a
Purity
≥98%(HPLC)
Packaging
5
Price
$171
Updated
2021/12/16
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CU-CPT-9a Chemical Properties,Usage,Production

Description

CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF-ĸB induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM.

Uses

CU-CPT9a is a potent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells.

CU-CPT-9a Preparation Products And Raw materials

Raw materials

Preparation Products

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CU-CPT-9a Suppliers

China 40 India 1 United States 6 Global 47
ShangHai Caerulum Pharma Discovery Co., Ltd.
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2162962-69-6, CU-CPT-9aRelated Search:

CU-CPT17e 4-(7-methoxyquinolin-4-yl)-2-methylphenol allyl isobutyrate 2137975-08-5 NDI-010976 CU-CPT-8m GW-870086

  • CPD1577
  • CU-CPT-9a
  • 2-Methyl-4-(7-hydroxy-4-quinolinyl)phenol
  • cas 2162962-69-6
  • CU-CPT-9A;CAS 2162962-69-6;TLR8 INHIBITOR
  • TLR8 inhibitor
  • TLR8-specific antagonist 1
  • 4-(4-hydroxy-3-methylphenyl)quinolin-7-ol
  • 7-Quinolinol, 4-(4-hydroxy-3-methylphenyl)-
  • inhibit,Toll-like Receptor (TLR),CU-CPT9b,Inhibitor,CUCPT9b,CU CPT9b
  • 2162962-69-6