ChemicalBook > CAS DataBase List > BOC-D-Methionine

BOC-D-Methionine

Product Name
BOC-D-Methionine
CAS No.
5241-66-7
Chemical Name
BOC-D-Methionine
Synonyms
BOC-D-MET;Boc-D-Met-OH;BOC-D-METHIONINE;n-box-d-methionine;N-BOC-D-METHIONINE;Boc-D-methionine99%;BOC-D-Methionine,98%;Boc-D-Met-OH;N-Boc-D-methionine, 98+%;N-ALPHA-T-BOC-D-METHIONINE
CBNumber
CB3337192
Molecular Formula
C10H19NO4S
Formula Weight
249.33
MOL File
5241-66-7.mol
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BOC-D-Methionine Property

Melting point:
47-50 °C
alpha 
23 º (c=1.3, methanol)
Boiling point:
415.5±40.0 °C(Predicted)
Density 
1.160±0.06 g/cm3(Predicted)
refractive index 
22 ° (C=1, MeOH)
storage temp. 
Sealed in dry,2-8°C
solubility 
soluble in Methanol
form 
Powder
pka
3.83±0.10(Predicted)
color 
White to off-white
BRN 
4294122
CAS DataBase Reference
5241-66-7(CAS DataBase Reference)
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
2930 90 98
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.53093
Product name
Boc-D-Met-OH
Purity
Novabiochem?
Packaging
25g
Price
$83.4
Updated
2025/07/31
Sigma-Aldrich
Product number
15132
Product name
Boc-D-Met-OH
Purity
≥98.0% (TLC)
Packaging
25g
Price
$420
Updated
2025/07/31
Sigma-Aldrich
Product number
15132
Product name
Boc-D-Met-OH
Purity
≥98.0% (TLC)
Packaging
5g
Price
$146
Updated
2023/06/20
TCI Chemical
Product number
B2967
Product name
N-(tert-Butoxycarbonyl)-D-methionine
Purity
>95.0%(HPLC)(T)
Packaging
5g
Price
$36
Updated
2025/07/31
TCI Chemical
Product number
B2967
Product name
N-(tert-Butoxycarbonyl)-D-methionine
Purity
>95.0%(HPLC)(T)
Packaging
25g
Price
$108
Updated
2025/07/31
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BOC-D-Methionine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

N-Boc-D-methionine is an N-Boc-protected form of D-Methionine (M260550). D-Methionine is an isomer of L-Methionine (M260440), and is known to be a cytoprotectant against Cisplatin (C499500), an anticancer agent. D-Methionine is also used to prevent noise- and drug-induced hearing loss, as well as hair loss (all of which may also be caused by Cisplatin or aminoglycosides).

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

348-67-4

24424-99-5

5241-66-7

(a) Preparation of tert-butoxycarbonyl-D-methionine: D-methionine (50.3 g, 0.34 mol) was dissolved in an aqueous solution (700 mL) containing sodium carbonate (71.5 g, 0.675 mol). To this solution was slowly added a solution of di-tert-butyl dicarbonate (81.0 g, 0.37 mol) in dioxane (250 mL), and the reaction mixture was stirred and reacted at room temperature for 16 hours. Upon completion of the reaction, it was diluted by adding water (1.5 L) and washed twice with ether (2 × 500 mL) to remove unreacted feedstock. Subsequently, the aqueous phase was acidified to pH 3 by addition of solid citric acid and the product was extracted with ethyl acetate (3 × 500 mL). The organic phases were combined, washed sequentially with water (2 × 500 mL) and saturated brine (500 mL), and finally dried with anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford tert-butoxycarbonyl-D-methionine as a colorless oil (87.6 g, 100% yield). The specific optical rotation of the product was [α]D +19.0° (c = 1%, methanol).

References

[1] Patent: US4863953, 1989, A
[2] Journal of the Chemical Society - Series Chemical Communications, 1989, # 22, p. 1740 - 1742
[3] Journal of Organic Chemistry, 1999, vol. 64, # 14, p. 5166 - 5175
[4] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4815 - 4830

BOC-D-Methionine Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-D-Methionine Suppliers

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View Lastest Price from BOC-D-Methionine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-D-Met-OH 5241-66-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-11-16
Career Henan Chemical Co
Product
BOC-D-Methionine 5241-66-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-16

5241-66-7, BOC-D-MethionineRelated Search:

1,1'-Carbonyldiimidazole tert-Butanol Zinc methionine sulfate L-Methionine N-Carbobenzyloxyglycine DL-Methionine S-ADENOSYL-L-METHIONINE 2-Chloro-2-methylpropane D-Methionine BOC-HYP-OL N-Boc-L-Phenylalaninol N-Boc-exo-3-aminotropane N-Boc-D-Phenylalaninol N-Boc-L-Homoserine BOC-D-ALPHA-T-BUTYLGLYCINE N-Boc-D-Valino Boc-Lys-OH NICKEL CARBONYL

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  • N-(tert-butyloxycarbonyl)-D-methionine
  • N-[(1,1-Dimethylethoxy)carbonyl]-D-methionine
  • BOC-D-Methionine,98%
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  • (2R)-2-[(tert-Butoxycarbonyl)amino]-4-(methylsulphonyl)butanoic acid
  • D-Methionine, N-BOC protected
  • BOC-D-Methionine(Boc-D-Met-OH)
  • (R)-2-((tert-butoxycarbonyl)aMino)-4-(Methylthio)butanoic acid
  • (Tert-Butoxy)Carbonyl D-Met-OH
  • Boc-D-methionine99%
  • (2R)-2-{[(tert-butoxy)carbonyl]amino}-4-(methylsulfanyl)butanoic acid
  • (2R)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-4-(methylthio)butanoate
  • N-(tert-Butoxycarbonyl)-D-methionine &gt
  • BOC-D-Methionine USP/EP/BP
  • Boc-<sc>D</sc>-Met-OH
  • 5241-66-7
  • Amino Acid Derivatives
  • Methionine
  • Peptide Synthesis
  • Specialty Synthesis
  • Amino Acids (N-Protected)
  • Biochemistry
  • Boc-Amino Acids
  • Methionine [Met, M]
  • Amino Acid Derivatives
  • Amino Acids