ChemicalBook > CAS DataBase List > 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE

1,2,3,4,5,6-HEXABROMOCYCLOHEXANE

Product Name
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
CAS No.
1837-91-8
Chemical Name
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
Synonyms
NSC 7908;JAK2 INHIBITOR II;BENZENE HEXABROMIDE;6-Hexabromocyclohexane;trans-α-Benzene hexabromide;1,2,3,4,5,6-Hexabromcyclohexan;1,2,3,4,5,6-HEXABROMOCYCLOHEXANE;1,2,3,4,5,6-hexabromo-cyclohexan;Cyclohexane, 1,2,3,4,5,6-hexabromo-;JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem
CBNumber
CB3337703
Molecular Formula
C6H6Br6
Formula Weight
557.54
MOL File
1837-91-8.mol
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1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Property

Melting point:
218.0 to 223.0 °C
storage temp. 
Store at RT
solubility 
DMSO: soluble2mg/mL (clear solution, warmed)
form 
powder
color 
white to beige
CAS DataBase Reference
1837-91-8(CAS DataBase Reference)
EPA Substance Registry System
Cyclohexane, 1,2,3,4,5,6-hexabromo- (1837-91-8)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-36-22
Safety Statements 
26-36/37/39
WGK Germany 
3
TSCA 
Yes
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
420132
Product name
JAK2 Inhibitor II
Packaging
25mg
Price
$172
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0455
Product name
1,2,3,4,5,6-Hexabromocyclohexane
Purity
≥98% (HPLC)
Packaging
50mg
Price
$127
Updated
2022/05/15
TCI Chemical
Product number
H0368
Product name
1,2,3,4,5,6-Hexabromocyclohexane
Packaging
5g
Price
$326
Updated
2021/12/16
TCI Chemical
Product number
H0368
Product name
1,2,3,4,5,6-Hexabromocyclohexane
Purity
min. 97.0 %
Packaging
1G
Price
$109
Updated
2021/12/16
Alfa Aesar
Product number
J60853
Product name
1,2,3,4,5,6-Hexabromocyclohexane
Packaging
1g
Price
$99.65
Updated
2024/03/01
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1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Chemical Properties,Usage,Production

Uses

1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation.

Definition

ChEBI: 1,2,3,4,5,6-hexabromocyclohexane is a bromohydrocarbon that is cyclohexane in which the hydrogen at positions 1,2,3,4,5 and 6 have been replaced by bromo groups. It is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a bromohydrocarbon and a bromoalkane. It derives from a hydride of a cyclohexane.

Biological Activity

Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μ M of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μ M elimates nearly all JAK2 activity. Non-cytotoxic at 100 μ M.

storage

Room temperature

1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Suppliers

J & K SCIENTIFIC LTD.
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View Lastest Price from 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE manufacturers

Henan Fengda Chemical Co., Ltd
Product
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE 1837-91-8
Price
US $101.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-28

1837-91-8, 1,2,3,4,5,6-HEXABROMOCYCLOHEXANERelated Search:


  • 1,2,3,4,5,6-hexabromo-cyclohexan
  • 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
  • BENZENE HEXABROMIDE
  • JAK2 INHIBITOR II
  • trans-α-Benzene hexabromide
  • 1,2,3,4,5,6-Hexabromcyclohexan
  • NSC 7908
  • JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem
  • Cyclohexane, 1,2,3,4,5,6-hexabromo-
  • 6-Hexabromocyclohexane
  • 1,2,3,4,5,6Hexabromocyclohexane,1,2,3,4,5,6 Hexabromocyclohexane
  • 1837-91-8
  • C6H6Br6