1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
- Product Name
- 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
- CAS No.
- 1837-91-8
- Chemical Name
- 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE
- Synonyms
- NSC 7908;JAK2 INHIBITOR II;BENZENE HEXABROMIDE;6-Hexabromocyclohexane;trans-α-Benzene hexabromide;1,2,3,4,5,6-Hexabromcyclohexan;1,2,3,4,5,6-HEXABROMOCYCLOHEXANE;1,2,3,4,5,6-hexabromo-cyclohexan;Cyclohexane, 1,2,3,4,5,6-hexabromo-;JAK2 Inhibitor II - CAS 1837-91-8 - Calbiochem
- CBNumber
- CB3337703
- Molecular Formula
- C6H6Br6
- Formula Weight
- 557.54
- MOL File
- 1837-91-8.mol
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Property
- Melting point:
- 218.0 to 223.0 °C
- storage temp.
- Store at RT
- solubility
- DMSO: soluble2mg/mL (clear solution, warmed)
- form
- powder
- color
- white to beige
- CAS DataBase Reference
- 1837-91-8(CAS DataBase Reference)
- EPA Substance Registry System
- Cyclohexane, 1,2,3,4,5,6-hexabromo- (1837-91-8)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-36-22
- Safety Statements
- 26-36/37/39
- WGK Germany
- 3
- TSCA
- Yes
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 420132
- Product name
- JAK2 Inhibitor II
- Packaging
- 25mg
- Price
- $172
- Updated
- 2024/03/01
- Product number
- SML0455
- Product name
- 1,2,3,4,5,6-Hexabromocyclohexane
- Purity
- ≥98% (HPLC)
- Packaging
- 50mg
- Price
- $127
- Updated
- 2022/05/15
- Product number
- H0368
- Product name
- 1,2,3,4,5,6-Hexabromocyclohexane
- Purity
- min. 97.0 %
- Packaging
- 1G
- Price
- $109
- Updated
- 2021/12/16
- Product number
- H0368
- Product name
- 1,2,3,4,5,6-Hexabromocyclohexane
- Packaging
- 5g
- Price
- $326
- Updated
- 2021/12/16
- Product number
- J60853
- Product name
- 1,2,3,4,5,6-Hexabromocyclohexane
- Packaging
- 1g
- Price
- $99.65
- Updated
- 2024/03/01
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Chemical Properties,Usage,Production
Uses
1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation.
Definition
ChEBI: 1,2,3,4,5,6-hexabromocyclohexane is a bromohydrocarbon that is cyclohexane in which the hydrogen at positions 1,2,3,4,5 and 6 have been replaced by bromo groups. It is a potent inhibitor of JAK2 tyrosine kinase autophosphorylation. It has a role as an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a bromohydrocarbon and a bromoalkane. It derives from a hydride of a cyclohexane.
Biological Activity
Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μ M of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μ M elimates nearly all JAK2 activity. Non-cytotoxic at 100 μ M.
storage
Room temperature
1,2,3,4,5,6-HEXABROMOCYCLOHEXANE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE manufacturers
- Product
- 1,2,3,4,5,6-HEXABROMOCYCLOHEXANE 1837-91-8
- Price
- US $101.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-28